Hspa13 heat shock protein 70 family, member 13 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Hspa13provided by MGI
Official Full Name: heat shock protein 70 family, member 13provided by MGI
Primary source: MGI:MGI:1309463
See related: Ensembl:ENSMUSG00000032932 AllianceGenome:MGI:1309463
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Stch; 1600002I10Rik; B230217N24Rik
Summary: Predicted to enable ATP hydrolysis activity; heat shock protein binding activity; and protein folding chaperone. Predicted to be involved in chaperone cofactor-dependent protein refolding and protein refolding. Predicted to be located in endoplasmic reticulum. Predicted to be active in cytosol; nucleus; and plasma membrane. Is expressed in several structures, including genitourinary system; gut; nervous system; sensory organ; and thymus. Orthologous to human HSPA13 (heat shock protein family A (Hsp70) member 13). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in placenta adult (RPKM 10.3), CNS E18 (RPKM 6.6) and 23 other tissues See more
Orthologs: human all
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Genomic context

Location:: 16 C3.1; 16 43.36 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	16	NC_000082.7 (75552078..75564575, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	16	NC_000082.6 (75755190..75767276, complement)

Chromosome 16 - NC_000082.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Single-cell atlas of splenocytes reveals a critical role of a novel plasma cellspecific marker Hspa13 in antibody class-switching recombination and somatic hypermutation.
Title: Single-cell atlas of splenocytes reveals a critical role of a novel plasma cell‒specific marker Hspa13 in antibody class-switching recombination and somatic hypermutation.
Hspa13 Promotes Plasma Cell Production and Antibody Secretion.
Title: Hspa13 Promotes Plasma Cell Production and Antibody Secretion.
Hspa13 (Stch) gene has a role in prion disease incubation time in mice
Title: Overexpression of the Hspa13 (Stch) gene reduces prion disease incubation time in mice.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Stch (e-PCR), detects polymorphism
- UniSTS:259149

AV006182 (e-PCR)
- UniSTS:180930

NoName (e-PCR)
- UniSTS:237530

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IBA Inferred from Biological aspect of Ancestor more info
enables ATP-dependent protein folding chaperone	IEA Inferred from Electronic Annotation more info
enables heat shock protein binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein folding chaperone	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in chaperone cofactor-dependent protein refolding	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein folding	IEA Inferred from Electronic Annotation more info
involved_in protein refolding	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: heat shock 70 kDa protein 13

Names: heat shock protein 70kDa family, member 13; microsomal stress-70 protein ATPase core; stress 70 protein chaperone, microsome-associated, 60kD human homolog; stress 70 protein chaperone, microsome-associated, human homolog; stress-70 protein chaperone microsome-associated 60 kDa protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_030201.3 → NP_084477.1 heat shock 70 kDa protein 13 precursor

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the functional protein.

Source sequence(s)

BC085181, BY133105, CO043820

Consensus CDS

CCDS28273.1

UniProtKB/Swiss-Prot

Q3TII6, Q8BM72, Q9D1X5

Related

ENSMUSP00000048817.9, ENSMUST00000046283.16

Conserved Domains (2) summary

cd10237
Location:12 → 463

HSPA13-like_NBD; Nucleotide-binding domain of human HSPA13 and similar proteins

PRK13930
Location:32 → 442

PRK13930; rod shape-determining protein MreB; Provisional

RNA

NR_027492.1 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (2) contains an alternate exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AK030553, BC085181, BY133105, CO043820

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000082.7 Reference GRCm39 C57BL/6J

Range

75552078..75564575 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006522849.4 → XP_006522912.1 heat shock 70 kDa protein 13 isoform X1

UniProtKB/TrEMBL

D3Z0Y0

Related

ENSMUSP00000109882.2, ENSMUST00000114244.2

Conserved Domains (1) summary

cl17037
Location:12 → 259

NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily