Kcnq1 potassium voltage-gated channel, subfamily Q, member 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Kcnq1provided by MGI
Official Full Name: potassium voltage-gated channel, subfamily Q, member 1provided by MGI
Primary source: MGI:MGI:108083
See related: Ensembl:ENSMUSG00000009545 AllianceGenome:MGI:108083
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Kcna9; KVLQT1
Summary: Enables voltage-gated potassium channel activity. Involved in several processes, including inner ear development; metal ion transport; and regulation of heart contraction. Acts upstream of or within digestive system process and membrane repolarization during ventricular cardiac muscle cell action potential. Located in apical plasma membrane and lumenal side of membrane. Part of voltage-gated potassium channel complex. Is active in several cellular components, including basolateral part of cell; ciliary base; and neuronal cell body. Is expressed in several structures, including alimentary system; extraembryonic component; heart; hemolymphoid system gland; and reproductive system. Used to study Jervell-Lange Nielsen syndrome and long QT syndrome 1. Human ortholog(s) of this gene implicated in heart conduction disease (multiple); long QT syndrome (multiple); and type 2 diabetes mellitus. Orthologous to human KCNQ1 (potassium voltage-gated channel subfamily Q member 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in large intestine adult (RPKM 20.0), colon adult (RPKM 19.5) and 10 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 F5; 7 88.12 cM

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (142660614..142980787)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (143106877..143427050)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

KCNQ1 is an essential mediator of the sex-dependent perception of moderate cold temperatures.
Title: KCNQ1 is an essential mediator of the sex-dependent perception of moderate cold temperatures.
Coronary and carotid artery dysfunction and KV7 overexpression in a mouse model of Hutchinson-Gilford progeria syndrome.
Title: Coronary and carotid artery dysfunction and K(V)7 overexpression in a mouse model of Hutchinson-Gilford progeria syndrome.
Age-dependent transition from islet insulin hypersecretion to hyposecretion in mice with the long QT-syndrome loss-of-function mutation Kcnq1-A340V.
Title: Age-dependent transition from islet insulin hypersecretion to hyposecretion in mice with the long QT-syndrome loss-of-function mutation Kcnq1-A340V.
KCNQ/M-channels play a role in regulating the excitability of vagal airway C-fibers at both the cell soma and nerve terminals.
Title: KCNQ/M-channels regulate mouse vagal bronchopulmonary C-fiber excitability and cough sensitivity.
It was concluded that KCNE2 regulates KCNQ1 in the lungs and is required for normal lung function and resistance to pulmonary ischemia/reperfusion injury.
Title: The KCNE2 potassium channel β subunit is required for normal lung function and resilience to ischemia and reperfusion injury.
As a consequence of KCNQ1 haploinsufficiency, these variants also cause LQTS on both maternal and paternal transmission. These results are consistent with the hypothesis that, similar to what has been demonstrated in mouse, lack of transcription across IC2 results in failure of methylation establishment in the female germline and BWS later in development, and also suggest a new link between LQTS and BWS that.
Title: Transcription alterations of KCNQ1 associated with imprinted methylation defects in the Beckwith-Wiedemann locus.
PKCepsilon isoenzyme mediates the inhibitory action of Angiotensin II on slowly activating delayed rectifier K(+) curren and by phosphorylating distinct sites in KCNQ1/KCNE1, cPKC and PKCepsilon isoenzymes produce the contrary regulatory effects on the channel.
Title: Protein kinase C epsilon mediates the inhibition of angiotensin II on the slowly activating delayed-rectifier potassium current through channel phosphorylation.
A double mutant mouse lacking both KCNQ1-KCNE3 and TASK-2 showed a much reduced cAMP-mediated anion secretion compared to that observed in the single KCNQ1-KCNE3 deficient mouse.
Title: K(2P) TASK-2 and KCNQ1-KCNE3 K(+) channels are major players contributing to intestinal anion and fluid secretion.
DNA hypermethylation of KCNQ1 promoter resulted in its downregulation in hepatocellular carcinoma (HCC). Bioinformatic analysis indicated a regulatory role of KCNQ1 in the epithelial-to-mesenchymal transition process. Gain-of-function study showed that KCNQ1 exhibited remarkable inhibitory roles on tumor metastasis in vitro and in vivo.
Title: Hypermethylated KCNQ1 acts as a tumor suppressor in hepatocellular carcinoma.
KCNQ activation decreased seizure latency by >/=50% in Kcnq1 strain mice but had no effect in the Kcna1 strain. However, in simultaneous EEG and ECG recordings, KCNQ activation significantly reduced spontaneous seizure frequency in Kcna1-/- mice by ~60%. In Kcnq1 mice, KCNQ activation produced adverse cardiac effects including profound bradycardia and abnormal increases in heart rate variability and AV conduction blocks.
Title: Pharmacogenetics of KCNQ channel activation in 2 potassium channelopathy mouse models of epilepsy.

Submit: New GeneRIF Correction See all GeneRIFs (56)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Chemically induced (ENU) (2) 1 citation
Endonuclease-mediated (4) 1 citation
Spontaneous (3)
Targeted (5) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Kcnq1 (e-PCR), detects polymorphism
- UniSTS:265495

NoName (e-PCR)
- UniSTS:235814

Kcnq1 (e-PCR), detects polymorphism
- UniSTS:143674

Kcnq1 (e-PCR), detects polymorphism
- UniSTS:143675

Kcnq1 (e-PCR), detects polymorphism
- UniSTS:143676

Kcnq1 (e-PCR), detects polymorphism
- UniSTS:143677

Kcnq1 (e-PCR), detects polymorphism
- UniSTS:143678

Kcnq1 (e-PCR), detects polymorphism
- UniSTS:143679

Kcnq1 (e-PCR), detects polymorphism
- UniSTS:143680

Kcnq1 (e-PCR), detects polymorphism
- UniSTS:143681

Kcnq1 (e-PCR), detects polymorphism
- UniSTS:143682

Kcnq1 (e-PCR), detects polymorphism
- UniSTS:143683

G36388 (e-PCR)
- UniSTS:49733

Kcnq1ot1 (e-PCR), detects polymorphism
- UniSTS:516697

Kcnq1 (e-PCR), detects polymorphism
- UniSTS:463213

Kcnq1 (e-PCR), detects polymorphism
- UniSTS:516464

Kcnq1ot1 (e-PCR), detects polymorphism
- UniSTS:516465

23H6.T7 (e-PCR), detects polymorphism
- UniSTS:140915

245A8.T7 (e-PCR), detects polymorphism
- UniSTS:140916

Kcnq1ot1 (e-PCR), detects polymorphism
- UniSTS:186521

Kcnq1ot1 (e-PCR), detects polymorphism
- UniSTS:532143

RH135848 (e-PCR)
- UniSTS:209846

Kcnq1 (e-PCR), detects polymorphism
- UniSTS:256980

AW559127 (e-PCR)
- UniSTS:179682

Kcnq1ot1 (e-PCR), detects polymorphism
- UniSTS:465395

UniSTS:465396 (e-PCR)
- UniSTS:465396

Kcnq1ot1 (e-PCR), detects polymorphism
- UniSTS:465396

Kcnq1 (e-PCR), detects polymorphism
- UniSTS:265461

Kcnq1ot1 (e-PCR), detects polymorphism
- UniSTS:465397

D7Mit175 (e-PCR), detects polymorphism
- UniSTS:131067

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables calmodulin binding	IEA Inferred from Electronic Annotation more info
enables calmodulin binding	ISO Inferred from Sequence Orthology more info
contributes_to delayed rectifier potassium channel activity	ISO Inferred from Sequence Orthology more info
enables delayed rectifier potassium channel activity	ISO Inferred from Sequence Orthology more info
enables delayed rectifier potassium channel activity	ISS Inferred from Sequence or Structural Similarity more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables outward rectifier potassium channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables outward rectifier potassium channel activity	ISO Inferred from Sequence Orthology more info
enables outward rectifier potassium channel activity	ISS Inferred from Sequence or Structural Similarity more info
enables phosphatidylinositol-4,5-bisphosphate binding	ISO Inferred from Sequence Orthology more info
enables phosphatidylinositol-4,5-bisphosphate binding	ISS Inferred from Sequence or Structural Similarity more info
enables potassium channel activity	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase A catalytic subunit binding	IEA Inferred from Electronic Annotation more info
enables protein kinase A catalytic subunit binding	ISO Inferred from Sequence Orthology more info
enables protein kinase A regulatory subunit binding	IEA Inferred from Electronic Annotation more info
enables protein kinase A regulatory subunit binding	ISO Inferred from Sequence Orthology more info
enables protein phosphatase 1 binding	IEA Inferred from Electronic Annotation more info
enables protein phosphatase 1 binding	ISO Inferred from Sequence Orthology more info
enables scaffold protein binding	IEA Inferred from Electronic Annotation more info
enables scaffold protein binding	ISO Inferred from Sequence Orthology more info
enables transmembrane transporter binding	IEA Inferred from Electronic Annotation more info
enables transmembrane transporter binding	ISO Inferred from Sequence Orthology more info
enables voltage-gated potassium channel activity	IDA Inferred from Direct Assay more info	PubMed
contributes_to voltage-gated potassium channel activity	ISO Inferred from Sequence Orthology more info
enables voltage-gated potassium channel activity	ISO Inferred from Sequence Orthology more info
enables voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization	IBA Inferred from Biological aspect of Ancestor more info
enables voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization	IEA Inferred from Electronic Annotation more info
enables voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization	ISO Inferred from Sequence Orthology more info
enables voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization	ISO Inferred from Sequence Orthology more info
enables voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization	IBA Inferred from Biological aspect of Ancestor more info
enables voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization	IEA Inferred from Electronic Annotation more info
enables voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in action potential	IBA Inferred from Biological aspect of Ancestor more info
involved_in adrenergic receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in atrial cardiac muscle cell action potential	ISO Inferred from Sequence Orthology more info
involved_in auditory receptor cell development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cardiac conduction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cardiac muscle cell contraction	NAS Non-traceable Author Statement more info	PubMed
involved_in cardiac muscle contraction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cardiac muscle contraction	ISO Inferred from Sequence Orthology more info
involved_in cellular response to cAMP	IEA Inferred from Electronic Annotation more info
involved_in cellular response to cAMP	ISO Inferred from Sequence Orthology more info
involved_in cellular response to epinephrine stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to xenobiotic stimulus	IEA Inferred from Electronic Annotation more info
involved_in cellular response to xenobiotic stimulus	ISO Inferred from Sequence Orthology more info
involved_in chloride ion homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cochlea development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in corticosterone secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in detection of mechanical stimulus involved in sensory perception of sound	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within digestive system process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in erythrocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in gastric acid secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in gastrin-induced gastric acid secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in glucose metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in heart development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within inner ear development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in inner ear development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in inner ear morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intestinal absorption	ISO Inferred from Sequence Orthology more info
involved_in intestinal absorption	ISS Inferred from Sequence or Structural Similarity more info
involved_in intracellular chloride ion homeostasis	IDA Inferred from Direct Assay more info	PubMed
involved_in intracellular chloride ion homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in iodide transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in membrane repolarization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in membrane repolarization during action potential	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in membrane repolarization during action potential	ISO Inferred from Sequence Orthology more info
involved_in membrane repolarization during atrial cardiac muscle cell action potential	IEA Inferred from Electronic Annotation more info
involved_in membrane repolarization during atrial cardiac muscle cell action potential	ISO Inferred from Sequence Orthology more info
involved_in membrane repolarization during cardiac muscle cell action potential	ISO Inferred from Sequence Orthology more info
involved_in membrane repolarization during cardiac muscle cell action potential	NAS Non-traceable Author Statement more info	PubMed
involved_in membrane repolarization during ventricular cardiac muscle cell action potential	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within membrane repolarization during ventricular cardiac muscle cell action potential	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in membrane repolarization during ventricular cardiac muscle cell action potential	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of delayed rectifier potassium channel activity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of insulin secretion	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of voltage-gated potassium channel activity	ISO Inferred from Sequence Orthology more info
involved_in non-motile cilium assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in non-motile cilium assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cardiac muscle contraction	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cardiac muscle contraction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of heart rate	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of heart rate	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of potassium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of potassium ion transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in potassium ion export across plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
involved_in potassium ion export across plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in potassium ion export across plasma membrane	NAS Non-traceable Author Statement more info	PubMed
involved_in potassium ion homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in potassium ion import across plasma membrane	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in potassium ion transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in potassium ion transmembrane transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in potassium ion transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in potassium ion transport	ISO Inferred from Sequence Orthology more info
involved_in regulation of atrial cardiac muscle cell membrane repolarization	IEA Inferred from Electronic Annotation more info
involved_in regulation of atrial cardiac muscle cell membrane repolarization	ISO Inferred from Sequence Orthology more info
involved_in regulation of blood pressure	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of gastric acid secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of heart rate	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of heart rate by cardiac conduction	IEA Inferred from Electronic Annotation more info
involved_in regulation of heart rate by cardiac conduction	ISO Inferred from Sequence Orthology more info
involved_in regulation of membrane potential	ISO Inferred from Sequence Orthology more info
involved_in regulation of membrane repolarization	ISO Inferred from Sequence Orthology more info
involved_in regulation of transporter activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of ventricular cardiac muscle cell membrane repolarization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of ventricular cardiac muscle cell membrane repolarization	ISO Inferred from Sequence Orthology more info
involved_in regulation of ventricular cardiac muscle cell membrane repolarization	NAS Non-traceable Author Statement more info	PubMed
involved_in regulation of voltage-gated sodium channel activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in renal absorption	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in renal sodium ion absorption	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to anesthetic	ISO Inferred from Sequence Orthology more info
involved_in response to insulin	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in rhythmic behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sensory perception of sound	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in social behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sodium ion transport	IDA Inferred from Direct Assay more info	PubMed
involved_in sodium ion transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in stomach development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ventricular cardiac muscle cell action potential	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in apical part of cell	IDA Inferred from Direct Assay more info	PubMed
is_active_in apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in basolateral part of cell	IDA Inferred from Direct Assay more info	PubMed
located_in basolateral plasma membrane	ISO Inferred from Sequence Orthology more info
located_in basolateral plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
is_active_in ciliary base	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoplasmic vesicle membrane	IEA Inferred from Electronic Annotation more info
colocalizes_with early endosome	ISO Inferred from Sequence Orthology more info
located_in early endosome	ISO Inferred from Sequence Orthology more info
colocalizes_with early endosome	ISS Inferred from Sequence or Structural Similarity more info
colocalizes_with endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
colocalizes_with endoplasmic reticulum	ISS Inferred from Sequence or Structural Similarity more info
located_in late endosome	IEA Inferred from Electronic Annotation more info
located_in late endosome	ISO Inferred from Sequence Orthology more info
located_in lumenal side of membrane	IDA Inferred from Direct Assay more info	PubMed
located_in lysosome	IEA Inferred from Electronic Annotation more info
located_in lysosome	ISO Inferred from Sequence Orthology more info
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	NAS Non-traceable Author Statement more info	PubMed
located_in membrane raft	ISO Inferred from Sequence Orthology more info
located_in membrane raft	ISS Inferred from Sequence or Structural Similarity more info
part_of monoatomic ion channel complex	ISO Inferred from Sequence Orthology more info
part_of monoatomic ion channel complex	ISS Inferred from Sequence or Structural Similarity more info
is_active_in neuron projection	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in neuronal cell body	IMP Inferred from Mutant Phenotype more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
part_of potassium channel complex	IDA Inferred from Direct Assay more info	PubMed
located_in sarcolemma	ISO Inferred from Sequence Orthology more info
is_active_in transport vesicle	IDA Inferred from Direct Assay more info	PubMed
part_of voltage-gated potassium channel complex	IBA Inferred from Biological aspect of Ancestor more info
part_of voltage-gated potassium channel complex	IDA Inferred from Direct Assay more info	PubMed
part_of voltage-gated potassium channel complex	IPI Inferred from Physical Interaction more info	PubMed
part_of voltage-gated potassium channel complex	ISO Inferred from Sequence Orthology more info
located_in zymogen granule membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: potassium voltage-gated channel subfamily KQT member 1

Names: IKs producing slow voltage-gated potassium channel subunit alpha KvLQT1; KQT-like 1; voltage-gated potassium channel subunit Kv7.1

NCBI Reference Sequences (RefSeq)

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NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001412611.1 → NP_001399540.1 potassium voltage-gated channel subfamily KQT member 1 isoform 2

Status: VALIDATED

Source sequence(s)

AC012540, AC015800, AC023248
NM_001412612.1 → NP_001399541.1 potassium voltage-gated channel subfamily KQT member 1 isoform 3

Status: VALIDATED

Source sequence(s)

AC012540, AC015800, AC023248
NM_008434.3 → NP_032460.2 potassium voltage-gated channel subfamily KQT member 1 isoform 1

See identical proteins and their annotated locations for NP_032460.2

Status: VALIDATED

Source sequence(s)

AC012540, AC015800, AC023248

Consensus CDS

CCDS22039.1

UniProtKB/Swiss-Prot

O88702, P97414, Q3U4H1, Q7TNZ1, Q7TPL7, Q80VR7

Related

ENSMUSP00000009689.5, ENSMUST00000009689.11

Conserved Domains (3) summary

pfam00520
Location:152 → 358

Ion_trans; Ion transport protein

pfam03520
Location:510 → 616

KCNQ_channel; KCNQ voltage-gated potassium channel

pfam07885
Location:269 → 348

Ion_trans_2; Ion channel

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000073.7 Reference GRCm39 C57BL/6J

Range

142660614..142980787

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006508492.3 → XP_006508555.1 potassium voltage-gated channel subfamily KQT member 1 isoform X6

Conserved Domains (2) summary

pfam00520
Location:12 → 246

Ion_trans; Ion transport protein

pfam03520
Location:398 → 504

KCNQ_channel; KCNQ voltage-gated potassium channel
XM_006508490.4 → XP_006508553.3 potassium voltage-gated channel subfamily KQT member 1 isoform X4

Conserved Domains (2) summary

PRK12323
Location:2 → 144

PRK12323; DNA polymerase III subunit gamma/tau

pfam00520
Location:176 → 412

Ion_trans; Ion transport protein
XM_006508491.4 → XP_006508554.3 potassium voltage-gated channel subfamily KQT member 1 isoform X5

Conserved Domains (2) summary

PRK12323
Location:2 → 144

PRK12323; DNA polymerase III subunit gamma/tau

pfam00520
Location:176 → 412

Ion_trans; Ion transport protein
XM_006508488.4 → XP_006508551.2 potassium voltage-gated channel subfamily KQT member 1 isoform X1

Conserved Domains (2) summary

pfam00520
Location:149 → 378

Ion_trans; Ion transport protein

pfam03520
Location:530 → 636

KCNQ_channel; KCNQ voltage-gated potassium channel
XM_011241982.3 → XP_011240284.2 potassium voltage-gated channel subfamily KQT member 1 isoform X2

Conserved Domains (2) summary

pfam00520
Location:149 → 378

Ion_trans; Ion transport protein

pfam03520
Location:530 → 605

KCNQ_channel; KCNQ voltage-gated potassium channel
XM_006508489.5 → XP_006508552.2 potassium voltage-gated channel subfamily KQT member 1 isoform X3

UniProtKB/TrEMBL

A0A087WNY7

Related

ENSMUSP00000139548.2, ENSMUST00000185383.2

Conserved Domains (1) summary

pfam00520
Location:149 → 378

Ion_trans; Ion transport protein
XM_036152718.1 → XP_036008611.1 potassium voltage-gated channel subfamily KQT member 1 isoform X7

Conserved Domains (2) summary

pfam00520
Location:27 → 226

Ion_trans; Ion transport protein

pfam03520
Location:378 → 484

KCNQ_channel; KCNQ voltage-gated potassium channel