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    Gm128 predicted gene 128 [ Mus musculus (house mouse) ]

    Gene ID: 229588, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Gm128provided by MGI
    Official Full Name
    predicted gene 128provided by MGI
    Primary source
    MGI:MGI:2684974
    See related
    Ensembl:ENSMUSG00000068860 AllianceGenome:MGI:2684974
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ment; pmis1
    Summary
    Involved in regulation of cell population proliferation. Predicted to be located in extracellular region. Orthologous to human C1orf56 (chromosome 1 open reading frame 56). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Restricted expression toward testis adult (RPKM 324.2) See more
    Orthologs
    human all
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    Genomic context

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    See Gm128 in Genome Data Viewer
    Location:
    3 F2.1; 3 40.74 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (95144230..95148946, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (95236919..95241635, complement)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene GA repeat binding protein, beta 2 Neighboring gene STARR-seq mESC enhancer starr_08372 Neighboring gene predicted gene, 16740 Neighboring gene myeloid/lymphoid or mixed-lineage leukemia; translocated to, 11 Neighboring gene CDC42 small effector 1 Neighboring gene BCL2/adenovirus E1B 19kD interacting protein like Neighboring gene prune exopolyphosphatase Neighboring gene STARR-positive B cell enhancer ABC_E2672 Neighboring gene MINDY lysine 48 deubiquitinase 1 Neighboring gene annexin A9 Neighboring gene STARR-positive B cell enhancer ABC_E9560 Neighboring gene predicted gene, 53243 Neighboring gene ceramide synthase 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Mice expressing aberrant sperm-specific protein PMIS2 produce normal-looking but fertilization-incompetent spermatozoa. Yamaguchi R, et al. Mol Biol Cell, 2012 Jul. PMID 22621904, Free PMC Article
    2. Loss of Dnmt3b function upregulates the tumor modifier Ment and accelerates mouse lymphomagenesis. Hlady RA, et al. J Clin Invest, 2012 Jan. PMID 22133874, Free PMC Article
    3. Mutagenesis of diploid mammalian genes by gene entrapment. Lin Q, et al. Nucleic Acids Res, 2006. PMID 17062627, Free PMC Article
    4. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
    5. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. identify Ment (Gm128) as an enhancer of lymphomagenesis that contributes to the tumor suppressor function of Dnmt3b
      Title: Loss of Dnmt3b function upregulates the tumor modifier Ment and accelerates mouse lymphomagenesis.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of cell population proliferation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of cell population proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    protein MENT
    Names
    methylated in normal thymocytes protein
    protein missing in infertile spermatozoa 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001024841.3 → NP_001020012.1  protein MENT precursor

      See identical proteins and their annotated locations for NP_001020012.1

      Status: PROVISIONAL

      Source sequence(s)
      AK144488
      Consensus CDS
      CCDS17608.1
      UniProtKB/Swiss-Prot
      Q569E4
      UniProtKB/TrEMBL
      G9MDF2
      Related
      ENSMUSP00000088324.6, ENSMUST00000090815.6
      Conserved Domains (1) summary
      pfam15322
      Location:36 → 345
      PMSI1; Protein missing in infertile sperm 1, putative

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      95144230..95148946 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030252579.1 → XP_030108439.1  protein MENT isoform X1

      UniProtKB/TrEMBL
      D3YUZ7
      Related
      ENSMUSP00000102815.2, ENSMUST00000107197.2
      Conserved Domains (1) summary
      pfam15322
      Location:36 → 183
      PMSI1; Protein missing in infertile sperm 1, putative
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q569E4.1 GenPept UniProtKB/Swiss-Prot:Q569E4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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