U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Ube2q2 ubiquitin-conjugating enzyme E2Q family member 2 [ Mus musculus (house mouse) ]

    Gene ID: 109161, updated on 27-Nov-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Ube2q2provided by MGI
    Official Full Name
    ubiquitin-conjugating enzyme E2Q family member 2provided by MGI
    Primary source
    MGI:MGI:2388672
    See related
    Ensembl:ENSMUSG00000032307 AllianceGenome:MGI:2388672
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    3010021M21Rik
    Summary
    Enables ubiquitin conjugating enzyme activity. Predicted to be involved in protein K48-linked ubiquitination. Predicted to be located in cytoplasm. Predicted to be active in nucleus. Orthologous to human UBE2Q2 (ubiquitin conjugating enzyme E2 Q2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in cerebellum adult (RPKM 7.3), testis adult (RPKM 6.8) and 28 other tissues See more
    Orthologs
    human all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Ube2q2 in Genome Data Viewer
    Location:
    9 B; 9 29.84 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (55056602..55114813)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (55149369..55207529)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene cholinergic receptor, nicotinic, beta polypeptide 4 Neighboring gene STARR-seq mESC enhancer starr_24182 Neighboring gene STARR-seq mESC enhancer starr_24183 Neighboring gene STARR-seq mESC enhancer starr_24184 Neighboring gene STARR-seq mESC enhancer starr_24185 Neighboring gene karyopherin alpha 7 (importin alpha 8) pseudogene Neighboring gene STARR-seq mESC enhancer starr_24186 Neighboring gene F-box protein 22 Neighboring gene neuregulin 4 Neighboring gene serpine1 mRNA binding protein 1 pseudogene

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Demonstration of ubiquitin thiolester formation of UBE2Q2 (UBCi), a novel ubiquitin-conjugating enzyme with implantation site-specific expression. Melner MH, et al. Biol Reprod, 2006 Sep. PMID 16760379
    2. [Ubiquitin-conjugating enzyme UBE2Q2 participates in HUWE1-mediated protection on renal tubulointerstitial fibrosis]. Wang Z, et al. Sheng Li Xue Bao, 2022 Feb 25. PMID 35199132
    3. Extensive cryptic splicing upon loss of RBM17 and TDP43 in neurodegeneration models. Tan Q, et al. Hum Mol Genet, 2016 Dec 1. PMID 28007900, Free PMC Article
    4. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808
    5. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. [Ubiquitin-conjugating enzyme UBE2Q2 participates in HUWE1-mediated protection on renal tubulointerstitial fibrosis].
      Title: [Ubiquitin-conjugating enzyme UBE2Q2 participates in HUWE1-mediated protection on renal tubulointerstitial fibrosis].
    Submit: New GeneRIF Correction

    Variation

    Go to the top of the page Help

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Gene trapped (1) 

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Clone Names

    • MGC19370

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin conjugating enzyme activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin conjugating enzyme activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ubiquitin-protein transferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin-protein transferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein K48-linked ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein K48-linked ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein K48-linked ubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    ubiquitin-conjugating enzyme E2 Q2
    Names
    E2 ubiquitin-conjugating enzyme Q2
    ubiquitin carrier protein Q2
    ubiquitin-conjugating enzyme E2Q (putative) 2
    ubiquitin-protein ligase Q2
    NP_001333586.1
    NP_001333587.1
    NP_850931.2
    XP_030099863.1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001346657.1 → NP_001333586.1  ubiquitin-conjugating enzyme E2 Q2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC156832, AC157328, BE953253
      Consensus CDS
      CCDS85677.1
      UniProtKB/TrEMBL
      D3Z647
      Related
      ENSMUSP00000113336.2, ENSMUST00000121677.8

    2. NM_001346658.1 → NP_001333587.1  ubiquitin-conjugating enzyme E2 Q2 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC157328, AK076148, BE953253
      Consensus CDS
      CCDS85678.1
      UniProtKB/Swiss-Prot
      Q8K2Z8
      Related
      ENSMUSP00000112745.2, ENSMUST00000122441.2
      Conserved Domains (1) summary
      cd00195
      Location:86 → 242
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

    3. NM_180600.3 → NP_850931.2  ubiquitin-conjugating enzyme E2 Q2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AI227508, AK042515, AK150776
      Consensus CDS
      CCDS23201.1
      UniProtKB/Swiss-Prot
      Q3UBX3, Q3V3A5, Q8BUN2, Q8BVX5, Q8K2Z8
      Related
      ENSMUSP00000059798.9, ENSMUST00000059555.15
      Conserved Domains (1) summary
      cl00154
      Location:209 → 365
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      55056602..55114813
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030244003.2 → XP_030099863.1  ubiquitin-conjugating enzyme E2 Q2 isoform X1

      Conserved Domains (1) summary
      cd00195
      Location:60 → 216
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

    RNA

    1. XR_004935303.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8K2Z8.2 GenPept UniProtKB/Swiss-Prot:Q8K2Z8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous