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    Sp8 trans-acting transcription factor 8 [ Mus musculus (house mouse) ]

    Gene ID: 320145, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Sp8provided by MGI
    Official Full Name
    trans-acting transcription factor 8provided by MGI
    Primary source
    MGI:MGI:2443471
    See related
    Ensembl:ENSMUSG00000048562 AllianceGenome:MGI:2443471
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mBtd; D930049B17Rik
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in embryonic limb morphogenesis. Acts upstream of or within dorsal/ventral pattern formation and proximal/distal pattern formation. Predicted to be located in nucleus. Is expressed in several structures, including branchial arch; embryo ectoderm; limb bud; nose; and primitive streak. Orthologous to human SP8 (Sp8 transcription factor). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in frontal lobe adult (RPKM 5.4), whole brain E14.5 (RPKM 1.9) and 4 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Sp8 in Genome Data Viewer
    Location:
    12 F2; 12 63.48 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (118809968..118816313)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (118846288..118852578)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_33443 Neighboring gene predicted gene, 29689 Neighboring gene predicted gene 6171 Neighboring gene ATP-binding cassette, sub-family B member 5 Neighboring gene STARR-seq mESC enhancer starr_33448 Neighboring gene STARR-positive B cell enhancer mm9_chr12:120165112-120165412 Neighboring gene STARR-seq mESC enhancer starr_33449 Neighboring gene STARR-seq mESC enhancer starr_33450 Neighboring gene STARR-seq mESC enhancer starr_33451 Neighboring gene STARR-seq mESC enhancer starr_33453 Neighboring gene acyl-Coenzyme A binding domain containing 5 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The transcription factor Sp8 is required for the production of parvalbumin-expressing interneurons in the olfactory bulb. Li X, et al. J Neurosci, 2011 Jun 8. PMID 21653849, Free PMC Article
    2. Transient Sp8+ handlebar-like interneuron structure traversing the corpus callosum during the second postnatal week. Cai Y, et al. Neuroreport, 2015 Mar 4. PMID 25646584
    3. Emx1-expressing neural stem cells in the subventricular zone give rise to new interneurons in the ischemic injured striatum. Wei B, et al. Eur J Neurosci, 2011 Mar. PMID 21219481
    4. A dual role for the transcription factor Sp8 in postnatal neurogenesis. Gaborieau E, et al. Sci Rep, 2018 Sep 28. PMID 30266956, Free PMC Article
    5. Further characterization of the juxtaglomerular neurons in the mouse main olfactory bulb by transcription factors, Sp8 and Tbx21. Kosaka T, et al. Neurosci Res, 2012 May. PMID 22387948

    See all (123) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Transcription factors Sp8 and Sp9 regulate the development of caudal ganglionic eminence-derived cortical interneurons.
      Title: Transcription factors Sp8 and Sp9 regulate the development of caudal ganglionic eminence-derived cortical interneurons.
    2. While Sp8 plays an early role in controlling proliferation in all lineages, it is not involved in the early specification of calretinin+ periglomerular interneurons, but plays a crucial role in their long term survival.
      Title: A dual role for the transcription factor Sp8 in postnatal neurogenesis.
    3. our results demonstrate that Sp8 and Sp9 have crucial roles in regulating olfactory bulb interneuron development
      Title: Transcription Factors Sp8 and Sp9 Coordinately Regulate Olfactory Bulb Interneuron Development.
    4. SP8 and SP9 coordinately promote D2-type medium spiny neuron production by activating Six3 expression.
      Title: SP8 and SP9 coordinately promote D2-type medium spiny neuron production by activating Six3 expression.
    5. Sp5/8 bind directly to GC boxes in Wnt target gene enhancers and to adjacent, or distally positioned, chromatin-bound T-cell factor (Tcf) 1/lymphoid enhancer factor (Lef) 1 to facilitate recruitment of beta-catenin to target gene enhancers.
      Title: Sp5 and Sp8 recruit β-catenin and Tcf1-Lef1 to select enhancers to activate Wnt target gene transcription.
    6. Provide the first direct evidence that a transient Sp8+ interneuron handlebar-like structure exists in the CC during a brief postnatal critical period.
      Title: Transient Sp8+ handlebar-like interneuron structure traversing the corpus callosum during the second postnatal week.
    7. Sp5 and Sp8 are pivotal downstream effectors of Wnt3a/beta-catenin that are essential for the self-renewal and differentiation of neuromesodermal stem cells.
      Title: Transcriptional profiling of Wnt3a mutants identifies Sp transcription factors as essential effectors of the Wnt/β-catenin pathway in neuromesodermal stem cells.
    8. Our data are compatible with Sp6 and Sp8 working together and in a dose-dependent manner as indispensable mediators of Wnt/betacatenin and Bmp signaling in the limb ectoderm
      Title: Sp6 and Sp8 transcription factors control AER formation and dorsal-ventral patterning in limb development.
    9. Findings provide evidence that Sp8 and another transcription factor, COUP-TF1, mutually repress each other's cortical neuroepithelial expression along the anterior-posterior and dorsoventral axes
      Title: Sp8 and COUP-TF1 reciprocally regulate patterning and Fgf signaling in cortical progenitors.
    10. The zinc-finger protein Sp8 plays a supplementary role to Pax6 in establishing the pMN/p3 domain boundary.
      Title: Sp8 plays a supplementary role to Pax6 in establishing the pMN/p3 domain boundary in the spinal cord.
    Submit: New GeneRIF Correction See all GeneRIFs (19)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (5)  1 citation

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC105193

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sequence-specific double-stranded DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sequence-specific double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within dorsal/ventral pattern formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within embryonic limb morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in embryonic limb morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within proximal/distal pattern formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    transcription factor Sp8

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001379379.1 → NP_001366308.1  transcription factor Sp8 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC131717, CN527217
      UniProtKB/TrEMBL
      Q640M8
      Conserved Domains (4) summary
      sd00017
      Location:379 → 398
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:434 → 456
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:420 → 443
      zf-H2C2_2; Zinc-finger double domain
      cl41771
      Location:19 → 375
      SP6-9_N; N-terminal domains of transcription factor Specificity Proteins (SP) 6-9, and similar proteins

    2. NM_001379380.1 → NP_001366309.1  transcription factor Sp8 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC131717, AK030745
      UniProtKB/Swiss-Prot
      Q8BMJ8, Q8BWA3
      UniProtKB/TrEMBL
      Q5QR90, Q640M8
      Conserved Domains (4) summary
      sd00017
      Location:361 → 380
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:416 → 438
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:402 → 425
      zf-H2C2_2; Zinc-finger double domain
      cl41771
      Location:1 → 357
      SP6-9_N; N-terminal domains of transcription factor Specificity Proteins (SP) 6-9, and similar proteins

    3. NM_177082.4 → NP_796056.2  transcription factor Sp8 isoform 2

      See identical proteins and their annotated locations for NP_796056.2

      Status: VALIDATED

      Source sequence(s)
      AC131717, AK053093
      Consensus CDS
      CCDS26213.1
      UniProtKB/Swiss-Prot
      Q8BMJ8, Q8BWA3
      UniProtKB/TrEMBL
      Q5QR90, Q640M8
      Related
      ENSMUSP00000065746.3, ENSMUST00000063918.4
      Conserved Domains (4) summary
      sd00017
      Location:361 → 380
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:416 → 438
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:402 → 425
      zf-H2C2_2; Zinc-finger double domain
      cl41771
      Location:1 → 357
      SP6-9_N; N-terminal domains of transcription factor Specificity Proteins (SP) 6-9, and similar proteins

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      118809968..118816313
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006515987.5 → XP_006516050.1  transcription factor Sp8 isoform X1

      See identical proteins and their annotated locations for XP_006516050.1

      UniProtKB/Swiss-Prot
      Q8BMJ8, Q8BWA3
      UniProtKB/TrEMBL
      Q5QR90, Q640M8
      Conserved Domains (4) summary
      sd00017
      Location:361 → 380
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:416 → 438
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:402 → 425
      zf-H2C2_2; Zinc-finger double domain
      cl41771
      Location:1 → 357
      SP6-9_N; N-terminal domains of transcription factor Specificity Proteins (SP) 6-9, and similar proteins

    2. XM_006515986.5 → XP_006516049.1  transcription factor Sp8 isoform X1

      See identical proteins and their annotated locations for XP_006516049.1

      UniProtKB/Swiss-Prot
      Q8BMJ8, Q8BWA3
      UniProtKB/TrEMBL
      Q5QR90, Q640M8
      Conserved Domains (4) summary
      sd00017
      Location:361 → 380
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:416 → 438
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:402 → 425
      zf-H2C2_2; Zinc-finger double domain
      cl41771
      Location:1 → 357
      SP6-9_N; N-terminal domains of transcription factor Specificity Proteins (SP) 6-9, and similar proteins

    3. XM_006515985.5 → XP_006516048.1  transcription factor Sp8 isoform X1

      See identical proteins and their annotated locations for XP_006516048.1

      UniProtKB/Swiss-Prot
      Q8BMJ8, Q8BWA3
      UniProtKB/TrEMBL
      Q5QR90, Q640M8
      Conserved Domains (4) summary
      sd00017
      Location:361 → 380
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:416 → 438
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:402 → 425
      zf-H2C2_2; Zinc-finger double domain
      cl41771
      Location:1 → 357
      SP6-9_N; N-terminal domains of transcription factor Specificity Proteins (SP) 6-9, and similar proteins

    4. XM_006515983.5 → XP_006516046.1  transcription factor Sp8 isoform X1

      See identical proteins and their annotated locations for XP_006516046.1

      UniProtKB/Swiss-Prot
      Q8BMJ8, Q8BWA3
      UniProtKB/TrEMBL
      Q5QR90, Q640M8
      Conserved Domains (4) summary
      sd00017
      Location:361 → 380
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:416 → 438
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:402 → 425
      zf-H2C2_2; Zinc-finger double domain
      cl41771
      Location:1 → 357
      SP6-9_N; N-terminal domains of transcription factor Specificity Proteins (SP) 6-9, and similar proteins

    5. XM_006515988.5 → XP_006516051.1  transcription factor Sp8 isoform X1

      See identical proteins and their annotated locations for XP_006516051.1

      UniProtKB/Swiss-Prot
      Q8BMJ8, Q8BWA3
      UniProtKB/TrEMBL
      Q5QR90, Q640M8
      Conserved Domains (4) summary
      sd00017
      Location:361 → 380
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:416 → 438
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:402 → 425
      zf-H2C2_2; Zinc-finger double domain
      cl41771
      Location:1 → 357
      SP6-9_N; N-terminal domains of transcription factor Specificity Proteins (SP) 6-9, and similar proteins

    6. XM_011244124.4 → XP_011242426.1  transcription factor Sp8 isoform X1

      See identical proteins and their annotated locations for XP_011242426.1

      UniProtKB/Swiss-Prot
      Q8BMJ8, Q8BWA3
      UniProtKB/TrEMBL
      Q5QR90, Q640M8
      Conserved Domains (4) summary
      sd00017
      Location:361 → 380
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:416 → 438
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:402 → 425
      zf-H2C2_2; Zinc-finger double domain
      cl41771
      Location:1 → 357
      SP6-9_N; N-terminal domains of transcription factor Specificity Proteins (SP) 6-9, and similar proteins
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BMJ8.1 GenPept UniProtKB/Swiss-Prot:Q8BMJ8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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