Rtn1 reticulon 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Rtn1provided by MGI
Official Full Name: reticulon 1provided by MGI
Primary source: MGI:MGI:1933947
See related: Ensembl:ENSMUSG00000021087 AllianceGenome:MGI:1933947
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Nsp
Summary: Predicted to be involved in endoplasmic reticulum tubular network formation; negative regulation of amyloid-beta formation; and nervous system development. Located in dendrite; endoplasmic reticulum; and neuronal cell body. Is expressed in several structures, including genitourinary system; immune system; nervous system; neural retina; and skin. Orthologous to human RTN1 (reticulon 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in CNS E18 (RPKM 186.8), whole brain E14.5 (RPKM 137.8) and 7 other tissues See more
Orthologs: human all
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Genomic context

Location:: 12 C3; 12 30.2 cM

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	12	NC_000078.7 (72258523..72455828, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	12	NC_000078.6 (72211749..72409054, complement)

Chromosome 12 - NC_000078.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Reticulons 1 and 3 are essential for axonal growth and synaptic maintenance associated with intellectual development.
Title: Reticulons 1 and 3 are essential for axonal growth and synaptic maintenance associated with intellectual development.
These data suggest that endoplasmic reticulum stress plays a major role in podocyte injury in diabetic nephropathy and RTN1A might be a key regulator of reticulum stress stress in podocytes.
Title: Rtn1a-Mediated Endoplasmic Reticulum Stress in Podocyte Injury and Diabetic Nephropathy.
reticulon-1 is responsible for reduced chemotaxis of macrophages differentiated from the one bone marrow of ultraviolet-irradiated and ultraviolet-chimeric mice
Title: Reticulon-1 and Reduced Migration toward Chemoattractants by Macrophages Differentiated from the Bone Marrow of Ultraviolet-Irradiated and Ultraviolet-Chimeric Mice.
RTN1A is a key mediator for proteinuria-induced tubular cell toxicity and renal fibrosis.
Title: Knockdown of RTN1A attenuates ER stress and kidney injury in albumin overload-induced nephropathy.
RTN1A contributes to progression of kidney disease by inducing ER stress.
Title: RTN1 mediates progression of kidney disease by inducing ER stress.
RTN-1C is able to specifically regulate gene expression, modulating transcript clusters which have been implicated in the onset of neurodegenerative disorders
Title: Characterization of gene expression induced by RTN-1C in human neuroblastoma cells and in mouse brain.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Gene trapped (1)
Targeted (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D12Mit201 (e-PCR), detects polymorphism
- UniSTS:116398

Rtn1 (e-PCR), detects polymorphism
- UniSTS:547529

RH125199 (e-PCR)
- UniSTS:162021

Gene Ontology Provided by MGI

Process	Evidence Code	Pubs
involved_in brain development	IBA Inferred from Biological aspect of Ancestor more info
involved_in endoplasmic reticulum tubular network formation	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of amyloid-beta formation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of amyloid-beta formation	ISS Inferred from Sequence or Structural Similarity more info
involved_in neuron differentiation	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in Golgi membrane	IEA Inferred from Electronic Annotation more info
located_in Golgi membrane	ISO Inferred from Sequence Orthology more info
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
is_active_in endoplasmic reticulum membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info
is_active_in neuron projection	IBA Inferred from Biological aspect of Ancestor more info
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynaptic density	IBA Inferred from Biological aspect of Ancestor more info
located_in smooth endoplasmic reticulum	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: reticulon-1

Names: neuroendocrine-specific protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001007596.2 → NP_001007597.1 reticulon-1 isoform C

See identical proteins and their annotated locations for NP_001007597.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks part of the 5' coding region, uses an alternate 5'-terminal exon, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (C) has a shorter and distinct N-terminus, compared to isoform A.

Source sequence(s)

AK014358, BC027091, BY615773, CX241467

Consensus CDS

CCDS25969.1

UniProtKB/TrEMBL

A3QM89, Q7M6W1

Related

ENSMUSP00000021497.10, ENSMUST00000021497.16

Conserved Domains (1) summary

pfam02453
Location:23 → 185

Reticulon
NM_001286448.1 → NP_001273377.1 reticulon-1 isoform A2

See identical proteins and their annotated locations for NP_001273377.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) lacks two in-frame exons in the central coding region, compared to variant 1. The encoded isoform (A2) is shorter, compared to variant 1.

Source sequence(s)

AK132364, BC027091, BC058579, BY615773

UniProtKB/TrEMBL

Q4FZ95

Conserved Domains (1) summary

pfam02453
Location:83 → 245

Reticulon; Reticulon
NM_153457.7 → NP_703187.2 reticulon-1 isoform A

See identical proteins and their annotated locations for NP_703187.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (A).

Source sequence(s)

AK132364, BC027091, BC058579, BY615773

Consensus CDS

CCDS25968.1

UniProtKB/Swiss-Prot

Q8K0T0, Q8K4S4

UniProtKB/TrEMBL

Q4FJL2

Related

ENSMUSP00000077594.8, ENSMUST00000078505.14

Conserved Domains (1) summary

pfam02453
Location:595 → 757

Reticulon; Reticulon

RNA

NR_104446.1 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (4) lacks several exons and uses an alternate 5'-terminal exon, compared to variant 1. This variant is represented as non-coding because the predicted protein does not meet RefSeq quality criteria.

Source sequence(s)

BC027091, BY615773, CT010476

Related

ENSMUST00000150156.2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000078.7 Reference GRCm39 C57BL/6J

Range

72258523..72455828 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030246489.1 → XP_030102349.1 reticulon-1 isoform X1

Conserved Domains (2) summary

PHA03307
Location:184 → 504

PHA03307; transcriptional regulator ICP4; Provisional

pfam02453
Location:514 → 676

Reticulon
XM_006515323.3 → XP_006515386.1 reticulon-1 isoform X1

See identical proteins and their annotated locations for XP_006515386.1

Conserved Domains (2) summary

PHA03307
Location:184 → 504

PHA03307; transcriptional regulator ICP4; Provisional

pfam02453
Location:514 → 676

Reticulon
XM_006515324.3 → XP_006515387.1 reticulon-1 isoform X1

See identical proteins and their annotated locations for XP_006515387.1

Conserved Domains (2) summary

PHA03307
Location:184 → 504

PHA03307; transcriptional regulator ICP4; Provisional

pfam02453
Location:514 → 676

Reticulon