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    Slc35a2 solute carrier family 35 (UDP-galactose transporter), member A2 [ Mus musculus (house mouse) ]

    Gene ID: 22232, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Slc35a2provided by MGI
    Official Full Name
    solute carrier family 35 (UDP-galactose transporter), member A2provided by MGI
    Primary source
    MGI:MGI:1345297
    See related
    Ensembl:ENSMUSG00000031156 AllianceGenome:MGI:1345297
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    UGT; Had1; Sfc8; Had-1; Ugalt
    Summary
    Enables UDP-galactose transmembrane transporter activity. Acts upstream of or within UDP-galactose transmembrane transport. Is active in Golgi membrane. Is expressed in several structures, including genitourinary system; heart; liver; lung; and spleen. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation type IIm. Orthologous to human SLC35A2 (solute carrier family 35 member A2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in colon adult (RPKM 48.8), adrenal adult (RPKM 22.5) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Slc35a2 in Genome Data Viewer
    Location:
    X A1.1; X 3.56 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (7750189..7760699)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (7883921..7894492)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_46674 Neighboring gene OTU domain containing 5 Neighboring gene STARR-positive B cell enhancer ABC_E11045 Neighboring gene proviral integration site 2 Neighboring gene STARR-positive B cell enhancer ABC_E7684 Neighboring gene polyglutamine binding protein 1 Neighboring gene translocase of inner mitochondrial membrane 17b

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Loss of Slc35a2 alters development of the mouse cerebral cortex. Elziny S, et al. Neurosci Lett, 2024 Jul 27. PMID 38909838
    2. Isolation and characterization of mouse FM3A cell mutants which are devoid of Newcastle disease virus receptors. Hara T, et al. J Virol, 1989 Jan. PMID 2535724, Free PMC Article
    3. Nucleotide sugar transporter SLC35A2 is involved in promoting hepatocellular carcinoma metastasis by regulating cellular glycosylation. Cheng H, et al. Cell Oncol (Dordr), 2023 Apr. PMID 36454514
    4. The UDP-galactose translocator gene is mapped to band Xp11.23-p11.22 containing the Wiskott-Aldrich syndrome locus. Hara T, et al. Somat Cell Mol Genet, 1993 Nov. PMID 8128316
    5. Point mutations identified in Lec8 Chinese hamster ovary glycosylation mutants that inactivate both the UDP-galactose and CMP-sialic acid transporters. Oelmann S, et al. J Biol Chem, 2001 Jul 13. PMID 11319223

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Loss of Slc35a2 alters development of the mouse cerebral cortex.
      Title: Loss of Slc35a2 alters development of the mouse cerebral cortex.
    2. Nucleotide sugar transporter SLC35A2 is involved in promoting hepatocellular carcinoma metastasis by regulating cellular glycosylation.
      Title: Nucleotide sugar transporter SLC35A2 is involved in promoting hepatocellular carcinoma metastasis by regulating cellular glycosylation.
    3. DEHP exposure did not influence lipase activity, whereas it slightly enhanced UGT activity and exclusively increased CYP4A14 levels in pregnant and/or postpartum dams.
      Title: Differences in metabolite burden of di(2-ethylhexyl)phthalate in pregnant and postpartum dams and their offspring in relation to drug-metabolizing enzymes in mice.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables UDP-galactose transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables UDP-galactose transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables UDP-galactose transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables antiporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in UDP-galactose transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within UDP-galactose transmembrane transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within UDP-galactose transmembrane transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in UDP-galactose transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in Golgi membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in Golgi membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in Golgi membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in Golgi membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    UDP-galactose translocator
    Names
    UDP-Gal-Tr
    UDP-galactose transporter
    mUGT1
    solute carrier family (UDP-N-acetylglucosamine transporter), member 2
    solute carrier family 35 (UDP-galactose transporter) member 2
    solute carrier family 35 (UDP-galactose transporter), member 2
    solute carrier family 35 member A2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001083937.2 → NP_001077406.1  UDP-galactose translocator isoform 2

      See identical proteins and their annotated locations for NP_001077406.1

      Status: VALIDATED

      Source sequence(s)
      AL671978
      Consensus CDS
      CCDS52987.1
      UniProtKB/Swiss-Prot
      Q9R0M8
      UniProtKB/TrEMBL
      Q3UIP1, Q9JIH0
      Related
      ENSMUSP00000111324.5, ENSMUST00000115660.12
      Conserved Domains (2) summary
      TIGR00803
      Location:114 → 338
      nst; UDP-galactose transporter
      pfam04142
      Location:31 → 339
      Nuc_sug_transp; Nucleotide-sugar transporter

    2. NM_001426060.1 → NP_001412989.1  UDP-galactose translocator isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL671978

    3. NM_001426061.1 → NP_001412990.1  UDP-galactose translocator isoform 4

      Status: VALIDATED

      Source sequence(s)
      AL671978
      UniProtKB/TrEMBL
      A0A140LI17
      Related
      ENSMUSP00000146635.2, ENSMUST00000208397.2

    4. NM_001426062.1 → NP_001412991.1  UDP-galactose translocator isoform 5

      Status: VALIDATED

      Source sequence(s)
      AL671978
      UniProtKB/TrEMBL
      F6WZ30
      Related
      ENSMUSP00000120681.3, ENSMUST00000153620.3

    5. NM_001426063.1 → NP_001412992.1  UDP-galactose translocator isoform 6

      Status: VALIDATED

      Source sequence(s)
      AL671978
      UniProtKB/TrEMBL
      F6QH15
      Related
      ENSMUSP00000116270.2, ENSMUST00000123277.8

    6. NM_001426064.1 → NP_001412993.1  UDP-galactose translocator isoform 7

      Status: VALIDATED

      Source sequence(s)
      AL671978
      UniProtKB/TrEMBL
      F6QH15

    7. NM_001426065.1 → NP_001412994.1  UDP-galactose translocator isoform 8

      Status: VALIDATED

      Source sequence(s)
      AL671978
      UniProtKB/TrEMBL
      A0A140LIP5

    8. NM_078484.3 → NP_511039.2  UDP-galactose translocator isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL671978
      Consensus CDS
      CCDS52986.1
      UniProtKB/TrEMBL
      A2AER4, Q9JIH0
      Related
      ENSMUSP00000111327.4, ENSMUST00000115663.10
      Conserved Domains (2) summary
      TIGR00803
      Location:114 → 338
      nst; UDP-galactose transporter
      pfam04142
      Location:31 → 339
      Nuc_sug_transp; Nucleotide-sugar transporter

    RNA

    1. NR_189662.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL671978

    2. NR_189663.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL671978

    3. NR_189664.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL671978

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      7750189..7760699
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030251303.2 → XP_030107163.2  UDP-galactose translocator isoform X1

      Conserved Domains (1) summary
      pfam04142
      Location:1 → 267
      Nuc_sug_transp; Nucleotide-sugar transporter

    2. XM_006527584.4 → XP_006527647.1  UDP-galactose translocator isoform X2

      Conserved Domains (1) summary
      pfam04142
      Location:1 → 181
      Nuc_sug_transp; Nucleotide-sugar transporter
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9R0M8.1 GenPept UniProtKB/Swiss-Prot:Q9R0M8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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