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    Uck1 uridine-cytidine kinase 1 [ Mus musculus (house mouse) ]

    Gene ID: 22245, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Uck1provided by MGI
    Official Full Name
    uridine-cytidine kinase 1provided by MGI
    Primary source
    MGI:MGI:98904
    See related
    Ensembl:ENSMUSG00000002550 AllianceGenome:MGI:98904
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    URK1; Umpk
    Summary
    Enables uridine kinase activity. Involved in UMP salvage. Predicted to be active in cytoplasm. Is expressed in nervous system; respiratory system; and urinary system. Orthologous to human UCK1 (uridine-cytidine kinase 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in mammary gland adult (RPKM 75.9), adrenal adult (RPKM 70.6) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Uck1 in Genome Data Viewer
    Location:
    2 B; 2 22.09 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (32145014..32150117, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (32255002..32260105, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene proline-rich coiled-coil 2B Neighboring gene predicted gene, 22192 Neighboring gene predicted gene, 25632 Neighboring gene protein-O-mannosyltransferase 1 Neighboring gene STARR-positive B cell enhancer ABC_E10094 Neighboring gene 60S ribosomal protein L36 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E9197 Neighboring gene SWI5 recombination repair homolog (yeast)

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Assignment of the gene for human uridine monophosphate kinase to chromosome 1 using somatic cell hybrid clone panels. Satlin A, et al. Cytogenet Cell Genet, 1975. PMID 172293
    2. The functions and consensus motifs of nine types of peptide segments that form different types of nucleotide-binding sites. Traut TW. Eur J Biochem, 1994 May 15. PMID 8200357
    3. Cloning and expression of a cDNA encoding uridine kinase from mouse brain. Ropp PA, et al. Arch Biochem Biophys, 1996 Dec 1. PMID 8951040
    4. Lifelong persistence of nuclear RNAs in the mouse brain. Zocher S, et al. Science, 2024 Apr 5. PMID 38574132, Free PMC Article
    5. Physical and transcriptional map of a 3-Mb region of mouse chromosome 1 containing the gene for the neural tube defect mutant loop-tail (Lp). Eddleston J, et al. Genomics, 1999 Mar 1. PMID 10051400

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cytidine kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables cytidine kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables uridine kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables uridine kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables uridine kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in CMP biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in CTP salvage IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in CTP salvage ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in CTP salvage ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in UMP salvage IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in UMP salvage IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in UMP salvage ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uridine-cytidine kinase 1
    Names
    cytidine monophosphokinase 1
    uridine monophosphate kinase
    uridine monophosphokinase 1
    NP_001365720.1
    NP_001365721.1
    NP_035805.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001378791.1 → NP_001365720.1  uridine-cytidine kinase 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL808027
      UniProtKB/Swiss-Prot
      P52623
      Conserved Domains (1) summary
      cd02023
      Location:31 → 254
      UMPK; Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway, ...

    2. NM_001378792.1 → NP_001365721.1  uridine-cytidine kinase 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL808027
      UniProtKB/Swiss-Prot
      P52623
      Conserved Domains (1) summary
      cd02023
      Location:12 → 187
      UMPK; Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway, ...

    3. NM_011675.2 → NP_035805.2  uridine-cytidine kinase 1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AK132100, BY338721, CJ194826, L31783
      Consensus CDS
      CCDS15909.2
      UniProtKB/Swiss-Prot
      P52623
      UniProtKB/TrEMBL
      A2AN37
      Related
      ENSMUSP00000002625.9, ENSMUST00000002625.15
      Conserved Domains (2) summary
      COG0572
      Location:24 → 238
      Udk; Uridine kinase [Nucleotide transport and metabolism]
      cd02023
      Location:31 → 236
      UMPK; Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway, ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      32145014..32150117 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P52623.2 GenPept UniProtKB/Swiss-Prot:P52623

    Gene LinkOut

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