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    Zc3h6 zinc finger CCCH type containing 6 [ Mus musculus (house mouse) ]

    Gene ID: 78751, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Zc3h6provided by MGI
    Official Full Name
    zinc finger CCCH type containing 6provided by MGI
    Primary source
    MGI:MGI:1926001
    See related
    Ensembl:ENSMUSG00000042851 AllianceGenome:MGI:1926001
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Zc3hdc6; mKIAA2035; 4631426G04Rik; 4833425H18Rik
    Summary
    Predicted to enable RNA binding activity and metal ion binding activity. Predicted to be involved in negative regulation of DNA-templated transcription. Predicted to be active in nucleus. Is expressed in central nervous system; early conceptus; and genitourinary system. Orthologous to human ZC3H6 (zinc finger CCCH-type containing 6). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in testis adult (RPKM 2.2), cerebellum adult (RPKM 2.2) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Zc3h6 in Genome Data Viewer
    Location:
    2 F1; 2 62.63 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (128809285..128860483)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (128967402..129018563)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene zinc finger CCCH type containing 8 Neighboring gene STARR-positive B cell enhancer ABC_E7861 Neighboring gene STARR-positive B cell enhancer ABC_E3403 Neighboring gene predicted gene 14028 Neighboring gene STARR-seq mESC enhancer starr_05655 Neighboring gene vinculin/alpha-catenin family member 1 Neighboring gene predicted gene, 54152 Neighboring gene STARR-seq mESC enhancer starr_05657 Neighboring gene tubulin tyrosine ligase Neighboring gene predicted gene, 46764

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Extensive molecular differences between anterior- and posterior-half-sclerotomes underlie somite polarity and spinal nerve segmentation. Hughes DS, et al. BMC Dev Biol, 2009 May 22. PMID 19463158, Free PMC Article
    2. Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst. Guo G, et al. Dev Cell, 2010 Apr 20. PMID 20412781
    3. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, et al. Science, 2004 Dec 24. PMID 15618518
    4. GUDMAP: the genitourinary developmental molecular anatomy project. McMahon AP, et al. J Am Soc Nephrol, 2008 Apr. PMID 18287559
    5. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, et al. Development, 2000 Apr. PMID 10725249

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA2035

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger CCCH domain-containing protein 6
    Names
    zinc finger CCCH type domain containing 6

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_178404.3 → NP_848491.2  zinc finger CCCH domain-containing protein 6

      See identical proteins and their annotated locations for NP_848491.2

      Status: VALIDATED

      Source sequence(s)
      AL833780
      Consensus CDS
      CCDS50707.1
      UniProtKB/Swiss-Prot
      A2AP87, Q80UK3, Q8BYK8, Q8C1H1, Q9D604
      UniProtKB/TrEMBL
      A2AP88
      Related
      ENSMUSP00000105949.3, ENSMUST00000110320.9
      Conserved Domains (1) summary
      smart00356
      Location:301 → 325
      ZnF_C3H1; zinc finger

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      128809285..128860483
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011239850.2 → XP_011238152.1  zinc finger CCCH domain-containing protein 6 isoform X1

      UniProtKB/Swiss-Prot
      A2AP87, Q80UK3, Q8BYK8, Q8C1H1, Q9D604
      Conserved Domains (2) summary
      pfam15663
      Location:246 → 325
      zf-CCCH_3; Zinc-finger containing family
      pfam18345
      Location:282 → 300
      zf_CCCH_4; Zinc finger domain

    2. XM_011239851.1 → XP_011238153.1  zinc finger CCCH domain-containing protein 6 isoform X2

      Conserved Domains (2) summary
      pfam15663
      Location:12 → 91
      zf-CCCH_3; Zinc-finger containing family
      pfam18345
      Location:48 → 66
      zf_CCCH_4; Zinc finger domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BYK8.2 GenPept UniProtKB/Swiss-Prot:Q8BYK8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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