Esm1 endothelial cell-specific molecule 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Esm1provided by MGI
Official Full Name: endothelial cell-specific molecule 1provided by MGI
Primary source: MGI:MGI:1918940
See related: Ensembl:ENSMUSG00000042379 AllianceGenome:MGI:1918940
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: ESM-1; 0610042H23Rik
Summary: Predicted to enable hepatocyte growth factor receptor binding activity and integrin binding activity. Predicted to be involved in positive regulation of cell population proliferation; positive regulation of hepatocyte growth factor receptor signaling pathway; and sprouting angiogenesis. Predicted to be located in extracellular region. Is expressed in several structures, including lower jaw; metanephros; neural retina; pineal primordium; and spleen. Orthologous to human ESM1 (endothelial cell specific molecule 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in kidney adult (RPKM 6.4), lung adult (RPKM 3.9) and 17 other tissues See more
Orthologs: human all
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Genomic context

Location:: 13 D2.2; 13 63.93 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	13	NC_000079.7 (113346193..113354638)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	13	NC_000079.6 (113209659..113218104)

Chromosome 13 - NC_000079.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Esm-1 mediates transcriptional polarization associated with diabetic kidney disease.
Title: Esm-1 mediates transcriptional polarization associated with diabetic kidney disease.
Intermittent hypoxia increased the expression of ESM1 and ICAM-1 in vascular endothelial cells via the downregulation of microRNA-181a1.
Title: Intermittent hypoxia increased the expression of ESM1 and ICAM-1 in vascular endothelial cells via the downregulation of microRNA-181a1.
ESM-1 Mediates Cell Progression in Clear Cell Renal Cell Carcinoma by Affecting Wnt/beta-Catenin Signalling Pathway.
Title: ESM-1 Mediates Cell Progression in Clear Cell Renal Cell Carcinoma by Affecting Wnt/β-Catenin Signalling Pathway.
Endothelial Cell-Specific Molecule-1 Inhibits Albuminuria in Diabetic Mice.
Title: Endothelial Cell-Specific Molecule-1 Inhibits Albuminuria in Diabetic Mice.
Data from murine model indicate that NGFR plays an important role in the pathogenesis and progression of oral squamous cell carcinoma via regulation of ESM1.
Title: ESM1 mediates NGFR-induced invasion and metastasis in murine oral squamous cell carcinoma.
glomerular-derived Esm-1 as a potential non-invasive biomarker of diabetic nephropathy
Title: Murine glomerular transcriptome links endothelial cell-specific molecule-1 deficiency with susceptibility to diabetic nephropathy.
Results reveal a novel pathway for endocan in the control of tumor growth, which involves inflammatory cells of the innate immunity.
Title: The non glycanated endocan polypeptide slows tumor growth by inducing stromal inflammatory reaction.
Esm1 modulates endothelial tip cell behavior and vascular permeability by enhancing VEGF bioavailability.
Title: Esm1 modulates endothelial tip cell behavior and vascular permeability by enhancing VEGF bioavailability.
This study shows endocan can elicit severe inflammatory responses and inhibiting endocan release offers a potential strategy for treating sepsis.
Title: Endocan elicits severe vascular inflammatory responses in vitro and in vivo.
endocan is normally present in the mouse brain and prior vascular perfusion with FITC may provide a useful tool for identify newly forming blood vessels.
Title: Endocan immunoreactivity in the mouse brain: method for identifying nonfunctional blood vessels.

Submit: New GeneRIF Correction See all GeneRIFs (13)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4) 1 citation
Targeted (3) 1 citation

General gene information

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Markers

AV004503 (e-PCR)
- UniSTS:180604

Esm1 (e-PCR), detects polymorphism
- UniSTS:496558

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables hepatocyte growth factor receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables hepatocyte growth factor receptor binding	IEA Inferred from Electronic Annotation more info
enables hepatocyte growth factor receptor binding	ISO Inferred from Sequence Orthology more info
enables integrin binding	IBA Inferred from Biological aspect of Ancestor more info
enables integrin binding	IEA Inferred from Electronic Annotation more info
enables integrin binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in angiogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of cell population proliferation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of hepatocyte growth factor receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of hepatocyte growth factor receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of hepatocyte growth factor receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in sprouting angiogenesis	IEA Inferred from Electronic Annotation more info
involved_in sprouting angiogenesis	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cellular_component	ND No biological Data available more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: endothelial cell-specific molecule 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.