Vgll2 vestigial like family member 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Vgll2provided by MGI
Official Full Name: vestigial like family member 2provided by MGI
Primary source: MGI:MGI:2447460
See related: Ensembl:ENSMUSG00000049641 AllianceGenome:MGI:2447460
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Vito1; vgl-2; VITO-1; C130057C21Rik
Summary: This gene is a member of the Vestigial-like (Vgl) gene family and is upregulated during muscle differentiation. The product of this gene interacts with and modifies the DNA-binding properties of the transcription factor, TEF-1, and is important for muscle tissue development. Reduced expression of this gene leads to a reduction in the terminal differentiation of muscle cells. Alternate splicing results in multiple protein isoforms. [provided by RefSeq, Jul 2014]
Expression: Biased expression in limb E14.5 (RPKM 21.9), mammary gland adult (RPKM 2.2) and 2 other tissues See more
Orthologs: human all
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Genomic context

Location:: 10 B3; 10 26.16 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (51898598..51904567)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (52022502..52028471)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These results suggest that Vgll2 may be both directly and indirectly involved in the programing of slow muscle fibers through the formation of the Vgll2-TEAD complex.
Title: Vestigial-like 2 contributes to normal muscle fiber type distribution in mice.
VITO-1 is a crucial new cofactor of the muscle regulatory programme; VITO-1, a new scalloped interaction domain-containing protein, binds to TEF1 in vitro and strongly stimulates transcription of a reporter plasmid together with TEF-1
Title: VITO-1 is an essential cofactor of TEF1-dependent muscle-specific gene regulation.
Vestigial like 2 homolog is required for muscle gene expression, in part by switching DNA binding of TEF-1 factors during muscle differentiation.
Title: Transcription cofactor Vgl-2 is required for skeletal muscle differentiation.
A transcription cofactor required for skeletal muscle differentiation that modifies DNA target selectivity of the Transcriptional Enhancer Factor-1 (TEF-1) transcription factors.
Title: Transcription cofactor Vgl-2 is required for skeletal muscle differentiation.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transcription coactivator activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within skeletal muscle tissue development	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: transcription cofactor vestigial-like protein 2

Names: vestigial like 2 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001300957.1 → NP_001287886.1 transcription cofactor vestigial-like protein 2 isoform 2

See identical proteins and their annotated locations for NP_001287886.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.

Source sequence(s)

AC153950, AF542181, AK052987

Consensus CDS

CCDS78812.1

UniProtKB/Swiss-Prot

Q8BGW8

UniProtKB/TrEMBL

A0A0R4J0M3

Conserved Domains (1) summary

pfam07545
Location:78 → 108

Vg_Tdu; Vestigial/Tondu family
NM_153786.2 → NP_722481.1 transcription cofactor vestigial-like protein 2 isoform 1

See identical proteins and their annotated locations for NP_722481.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AC153950, AF542181, AK048390

Consensus CDS

CCDS23837.1

UniProtKB/Swiss-Prot

Q8BGW8, Q8BWB4

Related

ENSMUSP00000124091.2, ENSMUST00000163017.10

Conserved Domains (1) summary

pfam07545
Location:78 → 108

Vg_Tdu; Vestigial/Tondu family