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    Gpr84 G protein-coupled receptor 84 [ Mus musculus (house mouse) ]

    Gene ID: 80910, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Gpr84provided by MGI
    Official Full Name
    G protein-coupled receptor 84provided by MGI
    Primary source
    MGI:MGI:1934129
    See related
    Ensembl:ENSMUSG00000063234 AllianceGenome:MGI:1934129
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    EX33
    Summary
    Predicted to enable urotensin II receptor activity. Predicted to be involved in neuropeptide signaling pathway. Predicted to be part of receptor complex. Predicted to be active in plasma membrane. Is expressed in adrenal gland; genitourinary system; gut; skin; and thoracic segment skeleton. Orthologous to human GPR84 (G protein-coupled receptor 84). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    human all
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    Genomic context

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    See Gpr84 in Genome Data Viewer
    Location:
    15 F3; 15 58.88 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (103216660..103219050, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (103308233..103310670, complement)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene coatomer protein complex, subunit zeta 1 Neighboring gene microRNA 148b Neighboring gene predicted gene, 41406 Neighboring gene STARR-positive B cell enhancer ABC_E3160 Neighboring gene STARR-positive B cell enhancer ABC_E1487 Neighboring gene zinc finger protein 385A Neighboring gene STARR-positive B cell enhancer ABC_E5521 Neighboring gene STARR-positive B cell enhancer mm9_chr15:103177678-103177979 Neighboring gene integrin alpha 5 (fibronectin receptor alpha) Neighboring gene microRNA 6963

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Medium-chain fatty acids suppress lipotoxicity-induced hepatic fibrosis via the immunomodulating receptor GPR84. Ohue-Kitano R, et al. JCI Insight, 2023 Jan 24. PMID 36480287, Free PMC Article
    2. G protein-coupled receptor 84 controls osteoclastogenesis through inhibition of NF-κB and MAPK signaling pathways. Park JW, et al. J Cell Physiol, 2018 Feb. PMID 28574596
    3. Effect of GPR84 deletion on obesity and diabetes development in mice fed long chain or medium chain fatty acid rich diets. Du Toit E, et al. Eur J Nutr, 2018 Aug. PMID 28429080
    4. On-target and off-target effects of novel orthosteric and allosteric activators of GPR84. Mancini SJ, et al. Sci Rep, 2019 Feb 12. PMID 30755705, Free PMC Article
    5. Regulation of mitochondrial metabolism in murine skeletal muscle by the medium-chain fatty acid receptor Gpr84. Montgomery MK, et al. FASEB J, 2019 Nov. PMID 31415180, Free PMC Article

    See all (39) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. G protein-coupled receptor 84 gene expression is regulated by the ER stress response in the liver.
      Title: G protein-coupled receptor 84 gene expression is regulated by the ER stress response in the liver.
    2. G-protein-coupled receptor 84 regulates acute inflammation in normal and diabetic skin wounds.
      Title: G-protein-coupled receptor 84 regulates acute inflammation in normal and diabetic skin wounds.
    3. Targeting metabolic sensing switch GPR84 on macrophages for cancer immunotherapy.
      Title: Targeting metabolic sensing switch GPR84 on macrophages for cancer immunotherapy.
    4. GPR84-mediated signal transduction affects metabolic function by promoting brown adipocyte activity.
      Title: GPR84-mediated signal transduction affects metabolic function by promoting brown adipocyte activity.
    5. MDSCs-derived GPR84 induces CD8[+] T-cell senescence via p53 activation to suppress the antitumor response.
      Title: MDSCs-derived GPR84 induces CD8(+) T-cell senescence via p53 activation to suppress the antitumor response.
    6. The GPR84 molecule is a mediator of a subpopulation of retinal microglia that promote TNF/IL-1alpha expression via the rho-ROCK pathway after optic nerve injury.
      Title: The GPR84 molecule is a mediator of a subpopulation of retinal microglia that promote TNF/IL-1α expression via the rho-ROCK pathway after optic nerve injury.
    7. GPR84 potently inhibits osteoclastogenesis and alleviates osteolysis in bone metastasis of colorectal cancer.
      Title: GPR84 potently inhibits osteoclastogenesis and alleviates osteolysis in bone metastasis of colorectal cancer.
    8. GPR84 signaling promotes intestinal mucosal inflammation via enhancing NLRP3 inflammasome activation in macrophages.
      Title: GPR84 signaling promotes intestinal mucosal inflammation via enhancing NLRP3 inflammasome activation in macrophages.
    9. Fatty acid sensing GPCR (GPR84) signaling safeguards cartilage homeostasis and protects against osteoarthritis.
      Title: Fatty acid sensing GPCR (GPR84) signaling safeguards cartilage homeostasis and protects against osteoarthritis.
    10. GPR84 Is Essential for the Taste of Medium Chain Saturated Fatty Acids.
      Title: GPR84 Is Essential for the Taste of Medium Chain Saturated Fatty Acids.
    Submit: New GeneRIF Correction See all GeneRIFs (18)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables urotensin II receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in neuropeptide signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of receptor complex ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    G-protein coupled receptor 84
    Names
    orphan G protein-coupled receptor 84

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001411984.1 → NP_001398913.1  G-protein coupled receptor 84

      Status: VALIDATED

      Source sequence(s)
      AC164069
      UniProtKB/TrEMBL
      A0A0R4J100

    2. NM_030720.3 → NP_109645.1  G-protein coupled receptor 84

      See identical proteins and their annotated locations for NP_109645.1

      Status: VALIDATED

      Source sequence(s)
      AC164069
      Consensus CDS
      CCDS27902.1
      UniProtKB/Swiss-Prot
      Q8CIM5, Q99MX9
      UniProtKB/TrEMBL
      A0A0R4J100
      Related
      ENSMUSP00000078753.5, ENSMUST00000079824.6
      Conserved Domains (1) summary
      cd15210
      Location:21 → 381
      7tmA_GPR84-like; G protein-coupled receptor 84 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      103216660..103219050 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036159641.1 → XP_036015534.1  G-protein coupled receptor 84 isoform X2

      UniProtKB/Swiss-Prot
      Q8CIM5, Q99MX9
      UniProtKB/TrEMBL
      A0A0R4J100
      Conserved Domains (1) summary
      cd15210
      Location:21 → 381
      7tmA_GPR84-like; G protein-coupled receptor 84 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8CIM5.1 GenPept UniProtKB/Swiss-Prot:Q8CIM5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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