Slc31a2 solute carrier family 31, member 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Slc31a2provided by MGI
Official Full Name: solute carrier family 31, member 2provided by MGI
Primary source: MGI:MGI:1333844
See related: Ensembl:ENSMUSG00000066152 AllianceGenome:MGI:1333844
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: CTR2
Summary: Predicted to enable copper ion transmembrane transporter activity. Acts upstream of or within intracellular copper ion homeostasis and regulation of copper ion transmembrane transport. Located in late endosome; membrane; and recycling endosome. Is expressed in brain; retina nuclear layer; and urinary system. Orthologous to human SLC31A2 (solute carrier family 31 member 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in genital fat pad adult (RPKM 27.9), adrenal adult (RPKM 15.7) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4 B3; 4 33.07 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (62198630..62216649)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (62280393..62298412)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Decreased Expression of the Slc31a1 Gene and Cytoplasmic Relocalization of Membrane CTR1 Protein in Renal Epithelial Cells: A Potent Protective Mechanism against Copper Nephrotoxicity in a Mouse Model of Menkes Disease.
Title: Decreased Expression of the Slc31a1 Gene and Cytoplasmic Relocalization of Membrane CTR1 Protein in Renal Epithelial Cells: A Potent Protective Mechanism against Copper Nephrotoxicity in a Mouse Model of Menkes Disease.
Gene duplication and neo-functionalization in the evolutionary and functional divergence of the metazoan copper transporters Ctr1 and Ctr2
Title: Gene duplication and neo-functionalization in the evolutionary and functional divergence of the metazoan copper transporters Ctr1 and Ctr2.
The increase in granular staining and heparin content is compatible with an impact of Ctr2 on mast cell maturation and, in support of this, the absence of Ctr2 resulted in markedly increased mRNA expression, storage, and enzymatic activity of tryptase.
Title: Ctr2 Regulates Mast Cell Maturation by Affecting the Storage and Expression of Tryptase and Proteoglycans.
In mouse embryo fibroblasts, reduction of CTR1 expression renders cells resistant to cisplatin whereas reduction of CTR2 makes them hypersensitive both in vitro and in vivo.
Title: Copper transporter 2 regulates intracellular copper and sensitivity to cisplatin.
Ctr2 regulates biogenesis of a cleaved form of mammalian Ctr1 metal transporter lacking the copper- and cisplatin-binding ecto-domain.
Title: Ctr2 regulates biogenesis of a cleaved form of mammalian Ctr1 metal transporter lacking the copper- and cisplatin-binding ecto-domain.
Copper transporter 2 regulates the transport of cisplatin through control of the rate of macropinocytosis.
Title: Copper transporter 2 regulates endocytosis and controls tumor growth and sensitivity to cisplatin in vivo.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AI604396 (e-PCR)
- UniSTS:165329

Slc31a2 (e-PCR), detects polymorphism
- UniSTS:546004

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
NOT enables copper ion transmembrane transporter activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables copper ion transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables copper ion transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in copper ion import	ISO Inferred from Sequence Orthology more info
involved_in copper ion import	ISS Inferred from Sequence or Structural Similarity more info
NOT acts_upstream_of_or_within copper ion transmembrane transport	IMP Inferred from Mutant Phenotype more info	PubMed
NOT acts_upstream_of_or_within copper ion transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in copper ion transport	ISO Inferred from Sequence Orthology more info
involved_in copper ion transport	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within intracellular copper ion homeostasis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within intracellular copper ion homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of copper ion transmembrane transport	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in late endosome	IDA Inferred from Direct Assay more info	PubMed
located_in late endosome membrane	ISO Inferred from Sequence Orthology more info
located_in late endosome membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in lysosomal membrane	ISO Inferred from Sequence Orthology more info
located_in lysosomal membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in recycling endosome	IDA Inferred from Direct Assay more info	PubMed
located_in recycling endosome membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: protein SLC31A2

Names: copper transporter 2; probable low affinity copper uptake protein 2; solute carrier family 31 (copper transporters), member 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001290518.1 → NP_001277447.1 protein SLC31A2 isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR and 5' coding region and initiates translation at a downstream start codon, compared to variant 1. It encodes isoform 2, which has a shorter N-terminus compared to isoform 1.

Source sequence(s)

AK015878, BC029183, BY482108

Consensus CDS

CCDS71401.1

UniProtKB/TrEMBL

Q3U9W6, Q9D524

Related

ENSMUSP00000103091.2, ENSMUST00000107467.3

Conserved Domains (1) summary

pfam04145
Location:1 → 133

Ctr; Ctr copper transporter family
NM_025286.3 → NP_079562.1 protein SLC31A2 isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

BB853212, BC029183, BY482108

Consensus CDS

CCDS18236.1

UniProtKB/Swiss-Prot

Q9CPU9

UniProtKB/TrEMBL

Q3U9W6, Q4KL43

Related

ENSMUSP00000081578.3, ENSMUST00000084530.9

Conserved Domains (1) summary

pfam04145
Location:1 → 135

Ctr; Ctr copper transporter family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000070.7 Reference GRCm39 C57BL/6J

Range

62198630..62216649

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006537712.2 → XP_006537775.1 protein SLC31A2 isoform X1

UniProtKB/TrEMBL

Q3U9W6, Q9D524

Related

ENSMUSP00000103092.2, ENSMUST00000107468.8

Conserved Domains (1) summary

pfam04145
Location:1 → 133

Ctr; Ctr copper transporter family