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    Cenpk centromere protein K [ Mus musculus (house mouse) ]

    Gene ID: 60411, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Cenpkprovided by MGI
    Official Full Name
    centromere protein Kprovided by MGI
    Primary source
    MGI:MGI:1926210
    See related
    Ensembl:ENSMUSG00000021714 AllianceGenome:MGI:1926210
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Solt; Solzt; Cenp-K; B130045K24Rik; C530004N04Rik
    Summary
    Acts upstream of or within positive regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including central nervous system and neural retina. Orthologous to human CENPK (centromere protein K). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in liver E14 (RPKM 9.5), CNS E11.5 (RPKM 6.6) and 9 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Cenpk in Genome Data Viewer
    Location:
    13 D1; 13 56.42 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (104365474..104386130)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (104228611..104249622)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E385 Neighboring gene STARR-seq mESC enhancer starr_35535 Neighboring gene STARR-positive B cell enhancer ABC_E4090 Neighboring gene tripartite motif-containing 23 Neighboring gene peptidylprolyl isomerase domain and WD repeat containing 1 Neighboring gene STARR-positive B cell enhancer ABC_E9887 Neighboring gene CapStarr-seq enhancer MGSCv37_chr13:105076891-105077195 Neighboring gene ADAM metallopeptidase with thrombospondin type 1 motif 6 Neighboring gene STARR-seq mESC enhancer starr_35536 Neighboring gene STARR-seq mESC enhancer starr_35537 Neighboring gene predicted gene 8680 Neighboring gene STARR-seq mESC enhancer starr_35538 Neighboring gene STARR-seq mESC enhancer starr_35540 Neighboring gene predicted gene, 53810 Neighboring gene CWC27 spliceosome-associated protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Characterization of Solt, a novel SoxLZ/Sox6 binding protein expressed in adult mouse testis. Yamashita A, et al. FEBS Lett, 2000 Sep 15. PMID 10996314
    2. Structural insights into human CCAN complex assembled onto DNA. Tian T, et al. Cell Discov, 2022 Sep 9. PMID 36085283, Free PMC Article
    3. Genomic analysis of mouse retinal development. Blackshaw S, et al. PLoS Biol, 2004 Sep. PMID 15226823, Free PMC Article
    4. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808
    5. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in chromosome segregation NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in kinetochore assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitotic sister chromatid segregation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of inner kinetochore ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus NAS
    Non-traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    centromere protein K
    Names
    SoxLZ/Sox6 leucine zipper binding protein in testis

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001377093.1 → NP_001364022.1  centromere protein K isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC154216
      UniProtKB/Swiss-Prot
      Q3UXA9, Q569Q3, Q8C469, Q9ESN5
      Conserved Domains (1) summary
      pfam11802
      Location:12 → 271
      CENP-K; Centromere-associated protein K

    2. NM_001377094.1 → NP_001364023.1  centromere protein K isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC154216
      UniProtKB/Swiss-Prot
      Q3UXA9, Q569Q3, Q8C469, Q9ESN5
      Conserved Domains (1) summary
      pfam11802
      Location:12 → 271
      CENP-K; Centromere-associated protein K

    3. NM_001377095.1 → NP_001364024.1  centromere protein K isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC154216
      UniProtKB/Swiss-Prot
      Q3UXA9, Q569Q3, Q8C469, Q9ESN5
      Conserved Domains (1) summary
      pfam11802
      Location:12 → 271
      CENP-K; Centromere-associated protein K

    4. NM_021790.2 → NP_068562.1  centromere protein K isoform 1

      See identical proteins and their annotated locations for NP_068562.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) uses alternate 5' exon structure, differs in the 5' UTR, and includes an alternate 3' terminal exon compared to variant 2. This transcript also initiates translation at an alternate start codon, resulting in isoform 1, which is longer and has distinct N- and C-termini compared to isoform 2.
      Source sequence(s)
      AB043687, AC154216, AV367397
      Consensus CDS
      CCDS26749.1
      UniProtKB/TrEMBL
      A0A0R4J037
      Related
      ENSMUSP00000022227.7, ENSMUST00000022227.8
      Conserved Domains (1) summary
      pfam11802
      Location:47 → 306
      CENP-K; Centromere-associated protein K

    5. NM_181061.6 → NP_851406.1  centromere protein K isoform 2

      See identical proteins and their annotated locations for NP_851406.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) represents the longest transcript and encodes the shorter isoform (2).
      Source sequence(s)
      AC154216
      Consensus CDS
      CCDS26750.1
      UniProtKB/Swiss-Prot
      Q9ESN5
      Related
      ENSMUSP00000070910.4, ENSMUST00000070761.10
      Conserved Domains (1) summary
      pfam11802
      Location:12 → 220
      CENP-K; Centromere-associated protein K

    RNA

    1. NR_075088.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate splice site in an internal exon and includes an alternate 3' terminal exon, compared to variant 2. This variant is represented as non-coding due to the presence of an upstream ORF that is predicted to interfere with translation of the longest ORF; translation of the upstream ORF renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC154216

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      104365474..104386130
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9ESN5.2 GenPept UniProtKB/Swiss-Prot:Q9ESN5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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