Gprc5a G protein-coupled receptor, family C, group 5, member A [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Gprc5aprovided by MGI
Official Full Name: G protein-coupled receptor, family C, group 5, member Aprovided by MGI
Primary source: MGI:MGI:1891250
See related: Ensembl:ENSMUSG00000046733 AllianceGenome:MGI:1891250
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Rai3; Raig1
Summary: Predicted to enable protein kinase activator activity. Involved in negative regulation of epidermal growth factor-activated receptor activity. Located in plasma membrane. Is expressed in several structures, including gut; nose; respiratory system; submandibular gland primordium; and urinary system. Orthologous to human GPRC5A (G protein-coupled receptor class C group 5 member A). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in lung adult (RPKM 130.8), colon adult (RPKM 45.8) and 4 other tissues See more
Orthologs: human all
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Genomic context

Location:: 6 G1; 6 65.83 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (135042660..135061707)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (135065662..135084709)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Influence of GPRC5A-Regulated ABCB1 Expression on Lung Adenocarcinoma Proliferation.
Title: Influence of GPRC5A-Regulated ABCB1 Expression on Lung Adenocarcinoma Proliferation.
Integrated Single-Cell RNA-Sequencing Analysis of Aquaporin 5-Expressing Mouse Lung Epithelial Cells Identifies GPRC5A as a Novel Validated Type I Cell Surface Marker.
Title: Integrated Single-Cell RNA-Sequencing Analysis of Aquaporin 5-Expressing Mouse Lung Epithelial Cells Identifies GPRC5A as a Novel Validated Type I Cell Surface Marker.
microRNA-367-3p regulation of GPRC5A is suppressed in ischemic stroke.
Title: microRNA-367-3p regulation of GPRC5A is suppressed in ischemic stroke.
PTGES/PGE2 signaling links immunosuppression and lung metastasis in Gprc5a-knockout mouse model.
Title: PTGES/PGE(2) signaling links immunosuppression and lung metastasis in Gprc5a-knockout mouse model.
Identification of Sca-1(+)Abcg1(+) bronchioalveolar epithelial cells as the origin of lung adenocarcinoma in Gprc5a-knockout mouse model through the interaction between lung progenitor AT2 and Lgr5 cells.
Title: Identification of Sca-1(+)Abcg1(+) bronchioalveolar epithelial cells as the origin of lung adenocarcinoma in Gprc5a-knockout mouse model through the interaction between lung progenitor AT2 and Lgr5 cells.
GPRC5A reduction contributes to pollutant benzo[a]pyrene injury via aggravating murine fibrosis, leading to poor prognosis of IIP patients.
Title: GPRC5A reduction contributes to pollutant benzo[a]pyrene injury via aggravating murine fibrosis, leading to poor prognosis of IIP patients.
On the basis of our findings in human DN and in Gprc5a deficient mice, we believe that chronic reduction in Gprc5a expression plays a pathogenic role in the progression of DN. Results in cell culture support our other findings in mice showing that Gprc5a modulates EGFR and TGF-b signaling in podocytes.
Title: Depletion of Gprc5a Promotes Development of Diabetic Nephropathy.
G protein-coupled receptor family C group 5 member A (GPRC5A) deficiency contributes to dysregulated proto-oncogene protein c-mdm2 (MDM2) via activated epidermal growth factor receptor (EGFR) signaling, which promotes lung tumor development.
Title: GPRC5A deficiency leads to dysregulated MDM2 via activated EGFR signaling for lung tumor development.
GPRC5a was upregulated in pancreatic cancer (PaCa) leading to an enhanced drug resistance in PaCa cells.
Title: The Effect of GPRC5a on the Proliferation, Migration Ability, Chemotherapy Resistance, and Phosphorylation of GSK-3β in Pancreatic Cancer.
under-expressed GPRC5A during lung tumorigenesis enhances any transcriptional stimulation through an active translational status.
Title: GPRC5A suppresses protein synthesis at the endoplasmic reticulum to prevent radiation-induced lung tumorigenesis.

Submit: New GeneRIF Correction See all GeneRIFs (20)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2) 1 citation
Targeted (2) 1 citation

General gene information

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Markers

Gprc5a (e-PCR), detects polymorphism
- UniSTS:536578

BF414790 (e-PCR)
- UniSTS:248750

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase activator activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of epidermal growth factor-activated receptor activity	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in extracellular exosome	IBA Inferred from Biological aspect of Ancestor more info
is_active_in intracellular membrane-bounded organelle	IBA Inferred from Biological aspect of Ancestor more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
part_of receptor complex	IBA Inferred from Biological aspect of Ancestor more info
located_in vesicle	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: retinoic acid-induced protein 3

Names: RAIG-1; retinoic acid induced 3; retinoic acid-induced gene 1 protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_181444.5 → NP_852109.2 retinoic acid-induced protein 3

See identical proteins and their annotated locations for NP_852109.2

Status: VALIDATED

Source sequence(s)

AC131718

Consensus CDS

CCDS20644.1

UniProtKB/Swiss-Prot

Q8BHL4, Q8K067, Q8K1G5

UniProtKB/TrEMBL

G5E8C3

Related

ENSMUSP00000061062.8, ENSMUST00000050104.8

Conserved Domains (1) summary

cd15279
Location:28 → 272

7tmC_RAIG1_4_GPRC5A_D; retinoic acid-inducible orphan G-protein-coupled receptors 1 and 4; class C family of seven-transmembrane G protein-coupled receptors, group 5, member A and D

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000072.7 Reference GRCm39 C57BL/6J

Range

135042660..135061707

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006506038.3 → XP_006506101.1 retinoic acid-induced protein 3 isoform X1

See identical proteins and their annotated locations for XP_006506101.1

UniProtKB/Swiss-Prot

Q8BHL4, Q8K067, Q8K1G5

UniProtKB/TrEMBL

G5E8C3

Conserved Domains (1) summary

cd15279
Location:28 → 272

7tmC_RAIG1_4_GPRC5A_D; retinoic acid-inducible orphan G-protein-coupled receptors 1 and 4; class C family of seven-transmembrane G protein-coupled receptors, group 5, member A and D