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    Drg1 developmentally regulated GTP binding protein 1 [ Mus musculus (house mouse) ]

    Gene ID: 13494, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Drg1provided by MGI
    Official Full Name
    developmentally regulated GTP binding protein 1provided by MGI
    Primary source
    MGI:MGI:1343297
    See related
    Ensembl:ENSMUSG00000020457 AllianceGenome:MGI:1343297
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    DRG-1; Nedd3; NEDD-3
    Summary
    Predicted to enable several functions, including GTP binding activity; GTPase activity; and potassium ion binding activity. Predicted to be involved in cytoplasmic translation; positive regulation of microtubule polymerization; and regulation of mitotic spindle assembly. Predicted to be located in cytosol and nuclear body. Predicted to be active in cytoplasm. Is expressed in several structures, including alimentary system; central nervous system; ear; genitourinary system; and integumental system. Orthologous to human DRG1 (developmentally regulated GTP binding protein 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in placenta adult (RPKM 29.0), CNS E11.5 (RPKM 28.8) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Drg1 in Genome Data Viewer
    Location:
    11 A1; 11 2.23 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (3199907..3221882, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (3249907..3266464, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene Sfi1 homolog, spindle assembly associated (yeast) Neighboring gene STARR-positive B cell enhancer ABC_E6943 Neighboring gene Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed (fox derived), pseudogene 2 Neighboring gene eukaryotic translation initiation factor 4E nuclear import factor 1 Neighboring gene predicted gene, 51877 Neighboring gene STARR-seq mESC enhancer starr_28343 Neighboring gene STARR-seq mESC enhancer starr_28345 Neighboring gene POZ (BTB) and AT hook containing zinc finger 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:3214183-3214292 Neighboring gene predicted gene 12592 Neighboring gene predicted gene 11944 Neighboring gene STARR-positive B cell enhancer ABC_E5203 Neighboring gene STARR-positive B cell enhancer ABC_E2345 Neighboring gene STARR-positive B cell enhancer ABC_E3929 Neighboring gene phosphoinositide-3-kinase interacting protein 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Inactivation of DRG1, encoding a translation factor GTPase, causes a recessive neurodevelopmental disorder. Westrip CAE, et al. Genet Med, 2023 Sep. PMID 37179472
    2. Expression of DRG during murine embryonic development. Sazuka T, et al. Biochem Biophys Res Commun, 1992 Nov 30. PMID 1280421
    3. DRG: a novel developmentally regulated GTP-binding protein. Sazuka T, et al. Biochem Biophys Res Commun, 1992 Nov 30. PMID 1449490
    4. Structure of the human protein kinase MPSK1 reveals an atypical activation loop architecture. Eswaran J, et al. Structure, 2008 Jan. PMID 18184589, Free PMC Article
    5. SCL binds the human homologue of DRG in vivo. Zhao XF, et al. Biochim Biophys Acta, 1998 Nov 19. PMID 9824680

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Inactivation of DRG1, encoding a translation factor GTPase, causes a recessive neurodevelopmental disorder.
      Title: Inactivation of DRG1, encoding a translation factor GTPase, causes a recessive neurodevelopmental disorder.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Gene trapped (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GTP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables membrane scission GTPase motor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables microtubule binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables microtubule binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables potassium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables potassium ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cytoplasmic translation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of microtubule polymerization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of microtubule polymerization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of mitotic spindle assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of mitotic spindle assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear body IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    developmentally-regulated GTP-binding protein 1
    Names
    GTP-binding protein
    TRAFAC GTPase DRG1
    neural precursor cell expressed developmentally down-regulated protein 3
    translation factor GTPase DRG1
    NP_031905.1
    XP_017169738.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_007879.2 → NP_031905.1  developmentally-regulated GTP-binding protein 1

      See identical proteins and their annotated locations for NP_031905.1

      Status: VALIDATED

      Source sequence(s)
      AL671968
      Consensus CDS
      CCDS24355.1
      UniProtKB/Swiss-Prot
      P32233
      UniProtKB/TrEMBL
      Q5NBZ3, Q8BNS0, Q8CHR8
      Related
      ENSMUSP00000020741.6, ENSMUST00000020741.12
      Conserved Domains (1) summary
      COG1163
      Location:1 → 367
      Rbg1; Ribosome-interacting GTPase 1 [Translation, ribosomal structure and biogenesis]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      3199907..3221882 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017314249.3 → XP_017169738.1  developmentally-regulated GTP-binding protein 1 isoform X1

      UniProtKB/TrEMBL
      Q8BNS0, Q8CHR8
      Conserved Domains (1) summary
      COG1163
      Location:1 → 334
      Rbg1; Ribosome-interacting GTPase 1 [Translation, ribosomal structure and biogenesis]
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P32233.1 GenPept UniProtKB/Swiss-Prot:P32233

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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