Cacna1c calcium channel, voltage-dependent, L type, alpha 1C subunit [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cacna1cprovided by MGI
Official Full Name: calcium channel, voltage-dependent, L type, alpha 1C subunitprovided by MGI
Primary source: MGI:MGI:103013
See related: Ensembl:ENSMUSG00000051331 AllianceGenome:MGI:103013
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: MBC; Cav1.2; Cchl1a1; MELC-CC; D930026N18Rik
Summary: Enables enzyme binding activity and voltage-gated calcium channel activity involved in cardiac muscle cell action potential. Involved in positive regulation of adenylate cyclase activity. Acts upstream of or within several processes, including adult walking behavior; regulation of blood circulation; and secretion by cell. Located in several cellular components, including T-tubule; Z disc; and dendritic shaft. Part of caveolar macromolecular signaling complex and voltage-gated calcium channel complex. Is expressed in several structures, including central nervous system; eye; genitourinary system; gut; and heart. Used to study Timothy syndrome. Human ortholog(s) of this gene implicated in Brugada syndrome 3; Timothy syndrome; long QT syndrome 8; and neurodevelopmental disorder with hypotonia, language delay, and skeletal defects with or without seizures. Orthologous to human CACNA1C (calcium voltage-gated channel subunit alpha1 C). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in heart adult (RPKM 11.2), adrenal adult (RPKM 6.3) and 16 other tissues See more
Orthologs: human all
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Genomic context

Location:: 6 F1; 6 55.86 cM

Exon count:: 53

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (118564201..119174345, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (118587240..119197384, complement)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Silencing of circCacna1c Inhibits ISO-Induced Cardiac Hypertrophy through miR-29b-2-5p/NFATc1 Axis.
Title: Silencing of circCacna1c Inhibits ISO-Induced Cardiac Hypertrophy through miR-29b-2-5p/NFATc1 Axis.
Increased Ca[2+] signaling through CaV 1.2 induces tendon hypertrophy with increased collagen fibrillogenesis and biomechanical properties.
Title: Increased Ca(2+) signaling through Ca(V) 1.2 induces tendon hypertrophy with increased collagen fibrillogenesis and biomechanical properties.
Neuronal deletion of CaV1.2 is associated with sex-specific behavioral phenotypes in mice.
Title: Neuronal deletion of Ca(V)1.2 is associated with sex-specific behavioral phenotypes in mice.
The CaV1.2 G406R mutation decreases synaptic inhibition and alters L-type Ca(2+) channel-dependent LTP at hippocampal synapses in a mouse model of Timothy Syndrome.
Title: The Ca(V)1.2 G406R mutation decreases synaptic inhibition and alters L-type Ca(2+) channel-dependent LTP at hippocampal synapses in a mouse model of Timothy Syndrome.
A molecular complex of Cav1.2/CaMKK2/CaMK1a in caveolae is responsible for vascular remodeling via excitation-transcription coupling.
Title: A molecular complex of Ca(v)1.2/CaMKK2/CaMK1a in caveolae is responsible for vascular remodeling via excitation-transcription coupling.
Mettl3 deficiency leads to the upregulation of Cav1.2 and increases arrhythmia susceptibility in mice.
Title: Mettl3 deficiency leads to the upregulation of Cav1.2 and increases arrhythmia susceptibility in mice.
Tachypacing-induced CREB/CD44 signaling contributes to the suppression of L-type calcium channel expression and the development of atrial remodeling.
Title: Tachypacing-induced CREB/CD44 signaling contributes to the suppression of L-type calcium channel expression and the development of atrial remodeling.
Interleukin-17 upregulation participates in the pathogenesis of heart failure in mice via NF-kappaB-dependent suppression of SERCA2a and Cav1.2 expression.
Title: Interleukin-17 upregulation participates in the pathogenesis of heart failure in mice via NF-κB-dependent suppression of SERCA2a and Cav1.2 expression.
Inhibiting microRNA-155 attenuates atrial fibrillation by targeting CACNA1C.
Title: Inhibiting microRNA-155 attenuates atrial fibrillation by targeting CACNA1C.
Dopamine D1R-neuron cacna1c deficiency: a new model of extinction therapy-resistant post-traumatic stress.
Title: Dopamine D1R-neuron cacna1c deficiency: a new model of extinction therapy-resistant post-traumatic stress.

Submit: New GeneRIF Correction See all GeneRIFs (153)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (7)
Gene trapped (1)
Targeted (18) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

L01776 (e-PCR)
- UniSTS:163399

Cacna1c (e-PCR), detects polymorphism
- UniSTS:461905

UniSTS:495979 (e-PCR)
- UniSTS:495979

Cacna1c (e-PCR), detects polymorphism
- UniSTS:495979

D4MGH30 (e-PCR)
- UniSTS:120437

UniSTS:259196 (e-PCR)
- UniSTS:259196

Cacna1c (e-PCR), detects polymorphism
- UniSTS:259196

D4Arb4 (e-PCR)
- UniSTS:240308

Cacna1c (e-PCR), detects polymorphism
- UniSTS:265414

D6Mit253 (e-PCR), detects polymorphism
- UniSTS:130802

12.MMHAP70FLD3.seq (e-PCR)
- UniSTS:123129

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables alpha-actinin binding	ISO Inferred from Sequence Orthology more info
enables alpha-actinin binding	ISS Inferred from Sequence or Structural Similarity more info
enables calmodulin binding	IEA Inferred from Electronic Annotation more info
enables calmodulin binding	ISO Inferred from Sequence Orthology more info
enables enzyme binding	IPI Inferred from Physical Interaction more info	PubMed
enables high voltage-gated calcium channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables high voltage-gated calcium channel activity	ISO Inferred from Sequence Orthology more info
enables high voltage-gated calcium channel activity	ISS Inferred from Sequence or Structural Similarity more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein domain specific binding	ISO Inferred from Sequence Orthology more info
enables protein phosphatase 2A binding	ISO Inferred from Sequence Orthology more info
enables translation initiation factor binding	ISO Inferred from Sequence Orthology more info
enables transmembrane transporter binding	ISO Inferred from Sequence Orthology more info
enables voltage-gated calcium channel activity	IDA Inferred from Direct Assay more info	PubMed
enables voltage-gated calcium channel activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables voltage-gated calcium channel activity	ISO Inferred from Sequence Orthology more info
enables voltage-gated calcium channel activity	TAS Traceable Author Statement more info	PubMed
enables voltage-gated calcium channel activity involved in AV node cell action potential	ISO Inferred from Sequence Orthology more info
enables voltage-gated calcium channel activity involved in AV node cell action potential	ISS Inferred from Sequence or Structural Similarity more info
enables voltage-gated calcium channel activity involved in cardiac muscle cell action potential	IDA Inferred from Direct Assay more info	PubMed
contributes_to voltage-gated calcium channel activity involved in cardiac muscle cell action potential	ISO Inferred from Sequence Orthology more info
enables voltage-gated calcium channel activity involved in cardiac muscle cell action potential	ISO Inferred from Sequence Orthology more info
contributes_to voltage-gated calcium channel activity involved in cardiac muscle cell action potential	ISS Inferred from Sequence or Structural Similarity more info
enables voltage-gated calcium channel activity involved in cardiac muscle cell action potential	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within adult walking behavior	IGI Inferred from Genetic Interaction more info	PubMed
involved_in calcium ion import	ISO Inferred from Sequence Orthology more info
involved_in calcium ion import across plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within calcium ion import across plasma membrane	IDA Inferred from Direct Assay more info	PubMed
involved_in calcium ion transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in calcium ion transmembrane transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in calcium ion transmembrane transport via high voltage-gated calcium channel	ISO Inferred from Sequence Orthology more info
involved_in calcium ion transmembrane transport via high voltage-gated calcium channel	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within calcium ion transport	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within calcium ion transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in calcium ion transport	ISO Inferred from Sequence Orthology more info
involved_in calcium ion transport into cytosol	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within calcium-ion regulated exocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in camera-type eye development	ISO Inferred from Sequence Orthology more info
involved_in cardiac conduction	ISO Inferred from Sequence Orthology more info
involved_in cardiac conduction	ISS Inferred from Sequence or Structural Similarity more info
involved_in cardiac muscle cell action potential involved in contraction	ISO Inferred from Sequence Orthology more info
involved_in cardiac muscle cell action potential involved in contraction	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within cell communication involved in cardiac conduction	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within chemical synaptic transmission	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in embryonic forelimb morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within establishment of localization in cell	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within establishment of localization in cell	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in exocytosis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within glucose homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within growth hormone secretion	IDA Inferred from Direct Assay more info	PubMed
involved_in heart development	ISO Inferred from Sequence Orthology more info
involved_in immune system development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within insulin secretion	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within intracellular calcium ion homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in membrane depolarization during AV node cell action potential	ISO Inferred from Sequence Orthology more info
involved_in membrane depolarization during AV node cell action potential	ISS Inferred from Sequence or Structural Similarity more info
involved_in membrane depolarization during atrial cardiac muscle cell action potential	ISO Inferred from Sequence Orthology more info
involved_in membrane depolarization during atrial cardiac muscle cell action potential	ISS Inferred from Sequence or Structural Similarity more info
involved_in membrane depolarization during cardiac muscle cell action potential	ISO Inferred from Sequence Orthology more info
involved_in membrane depolarization during cardiac muscle cell action potential	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of adenylate cyclase activity	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cytosolic calcium ion concentration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of insulin secretion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of membrane depolarization	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of muscle contraction	NAS Non-traceable Author Statement more info	PubMed
acts_upstream_of_or_within regulation of blood pressure	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of heart rate by cardiac conduction	ISO Inferred from Sequence Orthology more info
involved_in regulation of heart rate by cardiac conduction	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within regulation of organ growth	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of vasoconstriction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of ventricular cardiac muscle cell action potential	ISO Inferred from Sequence Orthology more info
involved_in regulation of ventricular cardiac muscle cell action potential	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to organic cyclic compound	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within smooth muscle contraction	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within smooth muscle contraction involved in micturition	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within visual learning	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of L-type voltage-gated calcium channel complex	ISO Inferred from Sequence Orthology more info
part_of L-type voltage-gated calcium channel complex	ISS Inferred from Sequence or Structural Similarity more info
located_in T-tubule	IDA Inferred from Direct Assay more info	PubMed
located_in T-tubule	ISO Inferred from Sequence Orthology more info
located_in T-tubule	TAS Traceable Author Statement more info	PubMed
located_in Z disc	IDA Inferred from Direct Assay more info	PubMed
located_in Z disc	ISO Inferred from Sequence Orthology more info
located_in axon	ISO Inferred from Sequence Orthology more info
part_of caveolar macromolecular signaling complex	IDA Inferred from Direct Assay more info	PubMed
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in dendrite	ISO Inferred from Sequence Orthology more info
located_in dendritic shaft	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
located_in perikaryon	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in plasma membrane	TAS Traceable Author Statement more info
located_in postsynaptic density	ISO Inferred from Sequence Orthology more info
located_in postsynaptic density membrane	IEA Inferred from Electronic Annotation more info
is_active_in postsynaptic membrane	ISO Inferred from Sequence Orthology more info
located_in postsynaptic membrane	ISO Inferred from Sequence Orthology more info
is_active_in presynaptic membrane	ISO Inferred from Sequence Orthology more info
located_in presynaptic membrane	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info
located_in sarcolemma	ISO Inferred from Sequence Orthology more info
part_of voltage-gated calcium channel complex	IBA Inferred from Biological aspect of Ancestor more info
part_of voltage-gated calcium channel complex	IMP Inferred from Mutant Phenotype more info	PubMed
part_of voltage-gated calcium channel complex	ISO Inferred from Sequence Orthology more info
part_of voltage-gated calcium channel complex	ISS Inferred from Sequence or Structural Similarity more info
part_of voltage-gated calcium channel complex	TAS Traceable Author Statement more info	PubMed

General protein information

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Preferred Names: voltage-dependent L-type calcium channel subunit alpha-1C

Names: brain class C; calcium channel voltage-dependent alpha1c subunit; neuronal voltage-gated calcium channel alpha 1C subunit; skeletal muscle-specific calcium channel; voltage-gated calcium channel subunit alpha Cav1.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001159533.2 → NP_001153005.1 voltage-dependent L-type calcium channel subunit alpha-1C isoform 2

See identical proteins and their annotated locations for NP_001153005.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) has an alternate 5' exon, as compared to variant 1. The resulting isoform (2) has a shorter and different N-terminus, as compared to isoform 1.

Source sequence(s)

AB259049, AC036121, AC126453, AW047472

Consensus CDS

CCDS80590.1

UniProtKB/Swiss-Prot

Q01815, Q04476, Q61242, Q99242

UniProtKB/TrEMBL

B7ZN95

Related

ENSMUSP00000077433.9, ENSMUST00000078320.14

Conserved Domains (5) summary

pfam00520
Location:1236 → 1487

Ion_trans; Ion transport protein

pfam08763
Location:1560 → 1631

Ca_chan_IQ; Voltage gated calcium channel IQ domain

pfam16885
Location:1654 → 2086

CAC1F_C; Voltage-gated calcium channel subunit alpha, C-term

pfam16905
Location:1495 → 1558

GPHH; Voltage-dependent L-type calcium channel, IQ-associated

cl01503
Location:202 → 291

TrbL; TrbL/VirB6 plasmid conjugal transfer protein
NM_001159534.2 → NP_001153006.1 voltage-dependent L-type calcium channel subunit alpha-1C isoform 3

Status: VALIDATED

Description

Transcript Variant: This variant (3) has an alternate 5' exon and an alternate internal exon in the CDS, as compared to variant 1. The resulting isoform (3) has a shorter and different N-terminus and a different internal segment, as compared to isoform 1.

Source sequence(s)

AB259049, AC036121, AC126453, AW047472, FM872409

Consensus CDS

CCDS80589.1

UniProtKB/TrEMBL

F8WJL1, Q5S8D1

Related

ENSMUSP00000108410.4, ENSMUST00000112790.9

Conserved Domains (4) summary

pfam00520
Location:1218 → 1487

Ion_trans; Ion transport protein

pfam08763
Location:1559 → 1633

Ca_chan_IQ; Voltage gated calcium channel IQ domain

pfam16885
Location:1653 → 2088

CAC1F_C; Voltage-gated calcium channel subunit alpha, C-term

pfam16905
Location:1496 → 1549

GPHH; Voltage-dependent L-type calcium channel, IQ-associated
NM_001159535.2 → NP_001153007.1 voltage-dependent L-type calcium channel subunit alpha-1C isoform 4

Status: VALIDATED

Description

Transcript Variant: This variant (4) has an alternate 5' exon and an alternate internal exon in the CDS, as compared to variant 1. The resulting isoform (4) has a shorter and different N-terminus and a shorter and different internal segment, as compared to isoform 1.

Source sequence(s)

AB259049, AC036121, AC126453, AW047472, FM872409

UniProtKB/TrEMBL

Q5S8D1

Conserved Domains (4) summary

pfam00520
Location:1218 → 1485

Ion_trans; Ion transport protein

pfam08763
Location:1557 → 1631

Ca_chan_IQ; Voltage gated calcium channel IQ domain

pfam16885
Location:1651 → 2086

CAC1F_C; Voltage-gated calcium channel subunit alpha, C-term

pfam16905
Location:1494 → 1547

GPHH; Voltage-dependent L-type calcium channel, IQ-associated
NM_001255997.2 → NP_001242926.1 voltage-dependent L-type calcium channel subunit alpha-1C isoform 5

See identical proteins and their annotated locations for NP_001242926.1

Status: VALIDATED

Description

Transcript Variant: This variant (5) has multiple differences in the coding region but maintains the reading frame, compared to variant 1. This variant encodes isoform 5, which is the same length as isoform 1.

Source sequence(s)

AC036121, AK052162, FM872409

Consensus CDS

CCDS80593.1

UniProtKB/TrEMBL

C7TQ57, C7TQ58

Related

ENSMUSP00000141033.2, ENSMUST00000187940.7

Conserved Domains (5) summary

pfam00520
Location:1266 → 1517

Ion_trans; Ion transport protein

pfam08763
Location:1590 → 1661

Ca_chan_IQ; Voltage gated calcium channel IQ domain

pfam16885
Location:1684 → 2116

CAC1F_C; Voltage-gated calcium channel subunit alpha, C-term

pfam16905
Location:1525 → 1588

GPHH; Voltage-dependent L-type calcium channel, IQ-associated

cl01503
Location:232 → 321

TrbL; TrbL/VirB6 plasmid conjugal transfer protein
NM_001255998.2 → NP_001242927.1 voltage-dependent L-type calcium channel subunit alpha-1C isoform 6

Status: VALIDATED

Description

Transcript Variant: This variant (6) has multiple differences in the coding region but maintains the reading frame, compared to variant 1. This variant encodes isoform 6, which is longer than isoform 1.

Source sequence(s)

AC036121, AC127328, AK052162, FM872410

Consensus CDS

CCDS80595.1

UniProtKB/TrEMBL

A0A087WSE7, C7TQ58

Related

ENSMUSP00000141015.2, ENSMUST00000190285.2

Conserved Domains (5) summary

pfam00520
Location:1291 → 1542

Ion_trans; Ion transport protein

pfam08763
Location:1615 → 1686

Ca_chan_IQ; Voltage gated calcium channel IQ domain

pfam16885
Location:1709 → 2141

CAC1F_C; Voltage-gated calcium channel subunit alpha, C-term

pfam16905
Location:1550 → 1613

GPHH; Voltage-dependent L-type calcium channel, IQ-associated

cl01503
Location:232 → 321

TrbL; TrbL/VirB6 plasmid conjugal transfer protein
NM_001255999.2 → NP_001242928.1 voltage-dependent L-type calcium channel subunit alpha-1C isoform 7

See identical proteins and their annotated locations for NP_001242928.1

Status: VALIDATED

Description

Transcript Variant: This variant (7) has multiple differences in the coding region but maintains the reading frame, compared to variant 1. This variant encodes isoform 7, which is the same length as isoform 1.

Source sequence(s)

AC036121, AK052162, FM872411

Consensus CDS

CCDS80594.1

UniProtKB/TrEMBL

C7TQ58, C7TQ59

Related

ENSMUSP00000140961.2, ENSMUST00000187474.7

Conserved Domains (4) summary

pfam00520
Location:1248 → 1517

Ion_trans; Ion transport protein

pfam08763
Location:1590 → 1661

Ca_chan_IQ; Voltage gated calcium channel IQ domain

pfam16885
Location:1683 → 2118

CAC1F_C; Voltage-gated calcium channel subunit alpha, C-term

pfam16905
Location:1526 → 1579

GPHH; Voltage-dependent L-type calcium channel, IQ-associated
NM_001256000.2 → NP_001242929.1 voltage-dependent L-type calcium channel subunit alpha-1C isoform 8

Status: VALIDATED

Description

Transcript Variant: This variant (8) differs in the 5' UTR and has multiple coding region differences, compared to variant 1. These differences cause translation initiation at an alternate AUG and result in an isoform (8) that is shorter and has a distinct N-terminus, compared to isoform 1.

Source sequence(s)

AC036121, AC126453, AC127328, FM872412

Consensus CDS

CCDS80588.1

UniProtKB/TrEMBL

A0A087WS40, C7TQ60

Related

ENSMUSP00000140886.2, ENSMUST00000188106.7

Conserved Domains (5) summary

pfam00520
Location:1261 → 1501

Ion_trans; Ion transport protein

pfam08763
Location:1574 → 1645

Ca_chan_IQ; Voltage gated calcium channel IQ domain

pfam16885
Location:1668 → 2100

CAC1F_C; Voltage-gated calcium channel subunit alpha, C-term

pfam16905
Location:1509 → 1572

GPHH; Voltage-dependent L-type calcium channel, IQ-associated

cl01503
Location:202 → 291

TrbL; TrbL/VirB6 plasmid conjugal transfer protein
NM_001256001.2 → NP_001242930.1 voltage-dependent L-type calcium channel subunit alpha-1C isoform 9

Status: VALIDATED

Description

Transcript Variant: This variant (9) differs in the 5' UTR and has multiple coding region differences, compared to variant 1. These differences cause translation initiation at an alternate AUG and result in an isoform (9) that is shorter and has a distinct N-terminus, compared to isoform 1.

Source sequence(s)

AC036121, AC126453, AC127328, FM872413

UniProtKB/TrEMBL

C7TQ61

Conserved Domains (5) summary

pfam00520
Location:1264 → 1504

Ion_trans; Ion transport protein

pfam08763
Location:1577 → 1648

Ca_chan_IQ; Voltage gated calcium channel IQ domain

pfam16885
Location:1671 → 2103

CAC1F_C; Voltage-gated calcium channel subunit alpha, C-term

pfam16905
Location:1512 → 1575

GPHH; Voltage-dependent L-type calcium channel, IQ-associated

cl01503
Location:202 → 291

TrbL; TrbL/VirB6 plasmid conjugal transfer protein
NM_001256002.2 → NP_001242931.1 voltage-dependent L-type calcium channel subunit alpha-1C isoform 10

Status: VALIDATED

Description

Transcript Variant: This variant (10) differs in the 5' UTR and has multiple coding region differences, compared to variant 1. These differences cause translation initiation at an alternate AUG and result in an isoform (10) that is longer and has a distinct N-terminus, compared to isoform 1.

Source sequence(s)

AC036121, AC126453, AC127328, FM872414

Consensus CDS

CCDS80587.1

UniProtKB/TrEMBL

C7TQ62, F7C376

Related

ENSMUSP00000108413.5, ENSMUST00000112793.10

Conserved Domains (5) summary

pfam00520
Location:141 → 416

Ion_trans; Ion transport protein

pfam08763
Location:1643 → 1714

Ca_chan_IQ; Voltage gated calcium channel IQ domain

pfam16885
Location:1737 → 2169

CAC1F_C; Voltage-gated calcium channel subunit alpha, C-term

pfam16905
Location:1578 → 1641

GPHH; Voltage-dependent L-type calcium channel, IQ-associated

cl01503
Location:202 → 291

TrbL; TrbL/VirB6 plasmid conjugal transfer protein
NM_001290335.1 → NP_001277264.1 voltage-dependent L-type calcium channel subunit alpha-1C isoform 11

Status: VALIDATED

Description

Transcript Variant: This variant (11) contains an alternate 5'-terminal exon, lacks part of the 5' coding region, uses a downstream start codon, and has multiple coding region differences, compared to variant 1. The encoded isoform (11) is shorter, compared to isoform 1.

Source sequence(s)

AC036121, AC127328, FM872412

Consensus CDS

CCDS71821.1

UniProtKB/TrEMBL

A0A1W2P6Z7

Related

ENSMUSP00000108444.3, ENSMUST00000112825.9

Conserved Domains (4) summary

pfam00520
Location:977 → 1217

Ion_trans; Ion transport protein

pfam08763
Location:1290 → 1361

Ca_chan_IQ; Voltage gated calcium channel IQ domain

pfam16885
Location:1384 → 1816

CAC1F_C; Voltage-gated calcium channel subunit alpha, C-term

pfam16905
Location:1225 → 1288

GPHH; Voltage-dependent L-type calcium channel, IQ-associated
NM_009781.4 → NP_033911.2 voltage-dependent L-type calcium channel subunit alpha-1C isoform 1

See identical proteins and their annotated locations for NP_033911.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longest isoform (1).

Source sequence(s)

AB259049, AC036121, AK052162

Consensus CDS

CCDS80592.1

UniProtKB/TrEMBL

C7TQ58, Q0PCR6

Related

ENSMUSP00000140056.2, ENSMUST00000186889.7

Conserved Domains (5) summary

pfam00520
Location:1266 → 1517

Ion_trans; Ion transport protein

pfam08763
Location:1590 → 1661

Ca_chan_IQ; Voltage gated calcium channel IQ domain

pfam16885
Location:1684 → 2116

CAC1F_C; Voltage-gated calcium channel subunit alpha, C-term

pfam16905
Location:1525 → 1588

GPHH; Voltage-dependent L-type calcium channel, IQ-associated

cl01503
Location:232 → 321

TrbL; TrbL/VirB6 plasmid conjugal transfer protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000072.7 Reference GRCm39 C57BL/6J

Range

118564201..119174345 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006505443.4 → XP_006505506.1 voltage-dependent L-type calcium channel subunit alpha-1C isoform X37

UniProtKB/TrEMBL

C7TQ58

Conserved Domains (4) summary

pfam00520
Location:153 → 446

Ion_trans; Ion transport protein

pfam08763
Location:1579 → 1650

Ca_chan_IQ; Voltage gated calcium channel IQ domain

pfam16885
Location:1672 → 2109

CAC1F_C; Voltage-gated calcium channel subunit alpha, C-term

pfam16905
Location:1515 → 1568

GPHH; Voltage-dependent L-type calcium channel, IQ-associated
XM_006505436.4 → XP_006505499.1 voltage-dependent L-type calcium channel subunit alpha-1C isoform X31

UniProtKB/TrEMBL

C7TQ58

Conserved Domains (4) summary

pfam00520
Location:153 → 446

Ion_trans; Ion transport protein

pfam08763
Location:1590 → 1661

Ca_chan_IQ; Voltage gated calcium channel IQ domain

pfam16885
Location:1683 → 2120

CAC1F_C; Voltage-gated calcium channel subunit alpha, C-term

pfam16905
Location:1526 → 1579

GPHH; Voltage-dependent L-type calcium channel, IQ-associated
XM_006505438.4 → XP_006505501.1 voltage-dependent L-type calcium channel subunit alpha-1C isoform X33

UniProtKB/TrEMBL

C7TQ58

Conserved Domains (4) summary

pfam00520
Location:1248 → 1517

Ion_trans; Ion transport protein

pfam08763
Location:1590 → 1661

Ca_chan_IQ; Voltage gated calcium channel IQ domain

pfam16885
Location:1683 → 2120

CAC1F_C; Voltage-gated calcium channel subunit alpha, C-term

pfam16905
Location:1526 → 1579

GPHH; Voltage-dependent L-type calcium channel, IQ-associated
XM_006505430.4 → XP_006505493.1 voltage-dependent L-type calcium channel subunit alpha-1C isoform X24

UniProtKB/TrEMBL

A0A087WQJ4

Conserved Domains (4) summary

pfam00520
Location:153 → 446

Ion_trans; Ion transport protein

pfam08763
Location:1607 → 1678

Ca_chan_IQ; Voltage gated calcium channel IQ domain

pfam16885
Location:1700 → 2137

CAC1F_C; Voltage-gated calcium channel subunit alpha, C-term

pfam16905
Location:1543 → 1596

GPHH; Voltage-dependent L-type calcium channel, IQ-associated
XM_006505442.4 → XP_006505505.1 voltage-dependent L-type calcium channel subunit alpha-1C isoform X39

UniProtKB/TrEMBL

C7TQ58

Conserved Domains (4) summary

pfam00520
Location:153 → 446

Ion_trans; Ion transport protein

pfam08763
Location:1579 → 1650

Ca_chan_IQ; Voltage gated calcium channel IQ domain

pfam16885
Location:1672 → 2109

CAC1F_C; Voltage-gated calcium channel subunit alpha, C-term

pfam16905
Location:1515 → 1568

GPHH; Voltage-dependent L-type calcium channel, IQ-associated
XM_006505434.4 → XP_006505497.1 voltage-dependent L-type calcium channel subunit alpha-1C isoform X32

UniProtKB/TrEMBL

C7TQ58

Conserved Domains (4) summary

pfam00520
Location:153 → 446

Ion_trans; Ion transport protein

pfam08763
Location:1590 → 1661

Ca_chan_IQ; Voltage gated calcium channel IQ domain

pfam16885
Location:1683 → 2120

CAC1F_C; Voltage-gated calcium channel subunit alpha, C-term

pfam16905
Location:1526 → 1579

GPHH; Voltage-dependent L-type calcium channel, IQ-associated
XM_006505437.4 → XP_006505500.1 voltage-dependent L-type calcium channel subunit alpha-1C isoform X34

UniProtKB/TrEMBL

C7TQ58

Conserved Domains (4) summary

pfam00520
Location:1248 → 1517

Ion_trans; Ion transport protein

pfam08763
Location:1590 → 1661

Ca_chan_IQ; Voltage gated calcium channel IQ domain

pfam16885
Location:1683 → 2120

CAC1F_C; Voltage-gated calcium channel subunit alpha, C-term

pfam16905
Location:1526 → 1579

GPHH; Voltage-dependent L-type calcium channel, IQ-associated
XM_006505426.4 → XP_006505489.1 voltage-dependent L-type calcium channel subunit alpha-1C isoform X18

UniProtKB/TrEMBL

A0A087WPP1

Conserved Domains (4) summary

pfam00520
Location:153 → 446

Ion_trans; Ion transport protein

pfam08763
Location:1618 → 1689

Ca_chan_IQ; Voltage gated calcium channel IQ domain

pfam16885
Location:1711 → 2148

CAC1F_C; Voltage-gated calcium channel subunit alpha, C-term

pfam16905
Location:1554 → 1607

GPHH; Voltage-dependent L-type calcium channel, IQ-associated
XM_006505418.4 → XP_006505481.1 voltage-dependent L-type calcium channel subunit alpha-1C isoform X13

UniProtKB/TrEMBL

A0A087WRM3

Conserved Domains (4) summary

pfam00520
Location:153 → 446

Ion_trans; Ion transport protein

pfam08763
Location:1638 → 1709

Ca_chan_IQ; Voltage gated calcium channel IQ domain

pfam16885
Location:1731 → 2168

CAC1F_C; Voltage-gated calcium channel subunit alpha, C-term

pfam16905
Location:1574 → 1627

GPHH; Voltage-dependent L-type calcium channel, IQ-associated
XM_036165775.1 → XP_036021668.1 voltage-dependent L-type calcium channel subunit alpha-1C isoform X11

UniProtKB/TrEMBL

A0A087WRM3

Conserved Domains (4) summary

pfam00520
Location:153 → 446

Ion_trans; Ion transport protein

pfam08763
Location:1641 → 1712

Ca_chan_IQ; Voltage gated calcium channel IQ domain

pfam16885
Location:1734 → 2169

CAC1F_C; Voltage-gated calcium channel subunit alpha, C-term

pfam16905
Location:1577 → 1630

GPHH; Voltage-dependent L-type calcium channel, IQ-associated
XM_006505440.4 → XP_006505503.1 voltage-dependent L-type calcium channel subunit alpha-1C isoform X36

UniProtKB/TrEMBL

C7TQ58

Conserved Domains (4) summary

pfam00520
Location:1253 → 1511

Ion_trans; Ion transport protein

pfam08763
Location:1584 → 1655

Ca_chan_IQ; Voltage gated calcium channel IQ domain

pfam16885
Location:1677 → 2114

CAC1F_C; Voltage-gated calcium channel subunit alpha, C-term

pfam16905
Location:1520 → 1573

GPHH; Voltage-dependent L-type calcium channel, IQ-associated
XM_006505427.4 → XP_006505490.1 voltage-dependent L-type calcium channel subunit alpha-1C isoform X23

UniProtKB/TrEMBL

C7TQ58

Related

ENSMUSP00000140341.2, ENSMUST00000187386.7

Conserved Domains (4) summary

pfam00520
Location:153 → 446

Ion_trans; Ion transport protein

pfam08763
Location:1615 → 1686

Ca_chan_IQ; Voltage gated calcium channel IQ domain

pfam16885
Location:1708 → 2145

CAC1F_C; Voltage-gated calcium channel subunit alpha, C-term

pfam16905
Location:1551 → 1604

GPHH; Voltage-dependent L-type calcium channel, IQ-associated
XM_006505432.4 → XP_006505495.1 voltage-dependent L-type calcium channel subunit alpha-1C isoform X29

UniProtKB/TrEMBL

C7TQ58

Conserved Domains (4) summary

pfam00520
Location:1273 → 1531

Ion_trans; Ion transport protein

pfam08763
Location:1604 → 1675

Ca_chan_IQ; Voltage gated calcium channel IQ domain

pfam16885
Location:1697 → 2134

CAC1F_C; Voltage-gated calcium channel subunit alpha, C-term

pfam16905
Location:1540 → 1593

GPHH; Voltage-dependent L-type calcium channel, IQ-associated
XM_036165770.1 → XP_036021663.1 voltage-dependent L-type calcium channel subunit alpha-1C isoform X2

UniProtKB/TrEMBL

C7TQ58

Conserved Domains (4) summary

pfam00520
Location:153 → 446

Ion_trans; Ion transport protein

pfam08763
Location:1666 → 1737

Ca_chan_IQ; Voltage gated calcium channel IQ domain

pfam16885
Location:1759 → 2194

CAC1F_C; Voltage-gated calcium channel subunit alpha, C-term

pfam16905
Location:1602 → 1655

GPHH; Voltage-dependent L-type calcium channel, IQ-associated
XM_006505439.4 → XP_006505502.1 voltage-dependent L-type calcium channel subunit alpha-1C isoform X35

UniProtKB/TrEMBL

C7TQ58

Conserved Domains (4) summary

pfam00520
Location:153 → 446

Ion_trans; Ion transport protein

pfam08763
Location:1588 → 1659

Ca_chan_IQ; Voltage gated calcium channel IQ domain

pfam16885
Location:1681 → 2118

CAC1F_C; Voltage-gated calcium channel subunit alpha, C-term

pfam16905
Location:1524 → 1577

GPHH; Voltage-dependent L-type calcium channel, IQ-associated
XM_006505435.4 → XP_006505498.1 voltage-dependent L-type calcium channel subunit alpha-1C isoform X30

UniProtKB/TrEMBL

C7TQ58

Conserved Domains (4) summary

pfam00520
Location:153 → 446

Ion_trans; Ion transport protein

pfam08763
Location:1590 → 1661

Ca_chan_IQ; Voltage gated calcium channel IQ domain

pfam16885
Location:1683 → 2120

CAC1F_C; Voltage-gated calcium channel subunit alpha, C-term

pfam16905
Location:1526 → 1579

GPHH; Voltage-dependent L-type calcium channel, IQ-associated
XM_006505441.4 → XP_006505504.1 voltage-dependent L-type calcium channel subunit alpha-1C isoform X38

UniProtKB/TrEMBL

C7TQ58

Conserved Domains (4) summary

pfam00520
Location:1248 → 1506

Ion_trans; Ion transport protein

pfam08763
Location:1579 → 1650

Ca_chan_IQ; Voltage gated calcium channel IQ domain

pfam16885
Location:1672 → 2109

CAC1F_C; Voltage-gated calcium channel subunit alpha, C-term

pfam16905
Location:1515 → 1568

GPHH; Voltage-dependent L-type calcium channel, IQ-associated
XM_036165776.1 → XP_036021669.1 voltage-dependent L-type calcium channel subunit alpha-1C isoform X12

UniProtKB/TrEMBL

A0A087WRM3

Conserved Domains (4) summary

pfam00520
Location:1268 → 1565

Ion_trans; Ion transport protein

pfam08763
Location:1638 → 1709

Ca_chan_IQ; Voltage gated calcium channel IQ domain

pfam16885
Location:1731 → 2166

CAC1F_C; Voltage-gated calcium channel subunit alpha, C-term

pfam16905
Location:1574 → 1627

GPHH; Voltage-dependent L-type calcium channel, IQ-associated
XM_036165774.1 → XP_036021667.1 voltage-dependent L-type calcium channel subunit alpha-1C isoform X10

UniProtKB/TrEMBL

A0A087WRM3

Conserved Domains (4) summary

pfam00520
Location:1271 → 1568

Ion_trans; Ion transport protein

pfam08763
Location:1641 → 1712

Ca_chan_IQ; Voltage gated calcium channel IQ domain

pfam16885
Location:1734 → 2169

CAC1F_C; Voltage-gated calcium channel subunit alpha, C-term

pfam16905
Location:1577 → 1630

GPHH; Voltage-dependent L-type calcium channel, IQ-associated
XM_036165780.1 → XP_036021673.1 voltage-dependent L-type calcium channel subunit alpha-1C isoform X21

UniProtKB/TrEMBL

C7TQ58

Conserved Domains (4) summary

pfam00520
Location:1273 → 1542

Ion_trans; Ion transport protein

pfam08763
Location:1615 → 1686

Ca_chan_IQ; Voltage gated calcium channel IQ domain

pfam16885
Location:1708 → 2143

CAC1F_C; Voltage-gated calcium channel subunit alpha, C-term

pfam16905
Location:1551 → 1604

GPHH; Voltage-dependent L-type calcium channel, IQ-associated
XM_017321358.2 → XP_017176847.1 voltage-dependent L-type calcium channel subunit alpha-1C isoform X8

UniProtKB/TrEMBL

C7TQ58

Conserved Domains (4) summary

pfam00520
Location:153 → 446

Ion_trans; Ion transport protein

pfam08763
Location:1643 → 1714

Ca_chan_IQ; Voltage gated calcium channel IQ domain

pfam16885
Location:1736 → 2173

CAC1F_C; Voltage-gated calcium channel subunit alpha, C-term

pfam16905
Location:1579 → 1632

GPHH; Voltage-dependent L-type calcium channel, IQ-associated
XM_036165781.1 → XP_036021674.1 voltage-dependent L-type calcium channel subunit alpha-1C isoform X22

UniProtKB/TrEMBL

C7TQ58

Conserved Domains (4) summary

pfam00520
Location:1273 → 1542

Ion_trans; Ion transport protein

pfam08763
Location:1615 → 1686

Ca_chan_IQ; Voltage gated calcium channel IQ domain

pfam16885
Location:1708 → 2143

CAC1F_C; Voltage-gated calcium channel subunit alpha, C-term

pfam16905
Location:1551 → 1604

GPHH; Voltage-dependent L-type calcium channel, IQ-associated
XM_030255125.1 → XP_030110985.1 voltage-dependent L-type calcium channel subunit alpha-1C isoform X28

UniProtKB/TrEMBL

C7TQ58

Conserved Domains (4) summary

pfam00520
Location:1273 → 1531

Ion_trans; Ion transport protein

pfam08763
Location:1604 → 1675

Ca_chan_IQ; Voltage gated calcium channel IQ domain

pfam16885
Location:1697 → 2134

CAC1F_C; Voltage-gated calcium channel subunit alpha, C-term

pfam16905
Location:1540 → 1593

GPHH; Voltage-dependent L-type calcium channel, IQ-associated
XM_006505415.4 → XP_006505478.1 voltage-dependent L-type calcium channel subunit alpha-1C isoform X9

UniProtKB/TrEMBL

C7TQ58

Conserved Domains (4) summary

pfam00520
Location:153 → 446

Ion_trans; Ion transport protein

pfam08763
Location:1643 → 1714

Ca_chan_IQ; Voltage gated calcium channel IQ domain

pfam16885
Location:1736 → 2173

CAC1F_C; Voltage-gated calcium channel subunit alpha, C-term

pfam16905
Location:1579 → 1632

GPHH; Voltage-dependent L-type calcium channel, IQ-associated
XM_036165772.1 → XP_036021665.1 voltage-dependent L-type calcium channel subunit alpha-1C isoform X4

UniProtKB/TrEMBL

C7TQ58

Conserved Domains (4) summary

pfam00520
Location:1293 → 1590

Ion_trans; Ion transport protein

pfam08763
Location:1663 → 1734

Ca_chan_IQ; Voltage gated calcium channel IQ domain

pfam16885
Location:1756 → 2191

CAC1F_C; Voltage-gated calcium channel subunit alpha, C-term

pfam16905
Location:1599 → 1652

GPHH; Voltage-dependent L-type calcium channel, IQ-associated
XM_011241184.3 → XP_011239486.1 voltage-dependent L-type calcium channel subunit alpha-1C isoform X16

UniProtKB/TrEMBL

C7TQ58

Conserved Domains (4) summary

pfam00520
Location:153 → 446

Ion_trans; Ion transport protein

pfam08763
Location:1626 → 1697

Ca_chan_IQ; Voltage gated calcium channel IQ domain

pfam16885
Location:1719 → 2156

CAC1F_C; Voltage-gated calcium channel subunit alpha, C-term

pfam16905
Location:1562 → 1615

GPHH; Voltage-dependent L-type calcium channel, IQ-associated
XM_011241185.3 → XP_011239487.1 voltage-dependent L-type calcium channel subunit alpha-1C isoform X17

UniProtKB/TrEMBL

C7TQ58

Conserved Domains (4) summary

pfam00520
Location:153 → 446

Ion_trans; Ion transport protein

pfam08763
Location:1618 → 1689

Ca_chan_IQ; Voltage gated calcium channel IQ domain

pfam16885
Location:1711 → 2148

CAC1F_C; Voltage-gated calcium channel subunit alpha, C-term

pfam16905
Location:1554 → 1607

GPHH; Voltage-dependent L-type calcium channel, IQ-associated
XM_011241186.3 → XP_011239488.1 voltage-dependent L-type calcium channel subunit alpha-1C isoform X26

UniProtKB/TrEMBL

C7TQ58

Conserved Domains (4) summary

pfam00520
Location:1276 → 1534

Ion_trans; Ion transport protein

pfam08763
Location:1607 → 1678

Ca_chan_IQ; Voltage gated calcium channel IQ domain

pfam16885
Location:1700 → 2137

CAC1F_C; Voltage-gated calcium channel subunit alpha, C-term

pfam16905
Location:1543 → 1596

GPHH; Voltage-dependent L-type calcium channel, IQ-associated
XM_017321362.2 → XP_017176851.1 voltage-dependent L-type calcium channel subunit alpha-1C isoform X20

UniProtKB/TrEMBL

C7TQ58

Conserved Domains (4) summary

pfam00520
Location:1276 → 1545

Ion_trans; Ion transport protein

pfam08763
Location:1618 → 1689

Ca_chan_IQ; Voltage gated calcium channel IQ domain

pfam16885
Location:1711 → 2148

CAC1F_C; Voltage-gated calcium channel subunit alpha, C-term

pfam16905
Location:1554 → 1607

GPHH; Voltage-dependent L-type calcium channel, IQ-associated
XM_011241175.3 → XP_011239477.1 voltage-dependent L-type calcium channel subunit alpha-1C isoform X6

UniProtKB/TrEMBL

C7TQ58

Conserved Domains (4) summary

pfam00520
Location:153 → 446

Ion_trans; Ion transport protein

pfam08763
Location:1646 → 1717

Ca_chan_IQ; Voltage gated calcium channel IQ domain

pfam16885
Location:1739 → 2176

CAC1F_C; Voltage-gated calcium channel subunit alpha, C-term

pfam16905
Location:1582 → 1635

GPHH; Voltage-dependent L-type calcium channel, IQ-associated
XM_036165782.1 → XP_036021675.1 voltage-dependent L-type calcium channel subunit alpha-1C isoform X25

UniProtKB/TrEMBL

C7TQ58

Conserved Domains (4) summary

pfam00520
Location:1276 → 1534

Ion_trans; Ion transport protein

pfam08763
Location:1607 → 1678

Ca_chan_IQ; Voltage gated calcium channel IQ domain

pfam16885
Location:1700 → 2135

CAC1F_C; Voltage-gated calcium channel subunit alpha, C-term

pfam16905
Location:1543 → 1596

GPHH; Voltage-dependent L-type calcium channel, IQ-associated
XM_036165779.1 → XP_036021672.1 voltage-dependent L-type calcium channel subunit alpha-1C isoform X19

UniProtKB/TrEMBL

C7TQ58

Conserved Domains (4) summary

pfam00520
Location:1276 → 1545

Ion_trans; Ion transport protein

pfam08763
Location:1618 → 1689

Ca_chan_IQ; Voltage gated calcium channel IQ domain

pfam16885
Location:1711 → 2146

CAC1F_C; Voltage-gated calcium channel subunit alpha, C-term

pfam16905
Location:1554 → 1607

GPHH; Voltage-dependent L-type calcium channel, IQ-associated
XM_011241187.3 → XP_011239489.1 voltage-dependent L-type calcium channel subunit alpha-1C isoform X27

UniProtKB/TrEMBL

C7TQ58

Conserved Domains (4) summary

pfam00520
Location:1276 → 1534

Ion_trans; Ion transport protein

pfam08763
Location:1607 → 1678

Ca_chan_IQ; Voltage gated calcium channel IQ domain

pfam16885
Location:1700 → 2137

CAC1F_C; Voltage-gated calcium channel subunit alpha, C-term

pfam16905
Location:1543 → 1596

GPHH; Voltage-dependent L-type calcium channel, IQ-associated
XM_011241176.3 → XP_011239478.1 voltage-dependent L-type calcium channel subunit alpha-1C isoform X7

UniProtKB/TrEMBL

C7TQ58

Conserved Domains (4) summary

pfam00520
Location:153 → 446

Ion_trans; Ion transport protein

pfam08763
Location:1646 → 1717

Ca_chan_IQ; Voltage gated calcium channel IQ domain

pfam16885
Location:1739 → 2176

CAC1F_C; Voltage-gated calcium channel subunit alpha, C-term

pfam16905
Location:1582 → 1635

GPHH; Voltage-dependent L-type calcium channel, IQ-associated
XM_036165777.1 → XP_036021670.1 voltage-dependent L-type calcium channel subunit alpha-1C isoform X14

UniProtKB/TrEMBL

C7TQ58

Conserved Domains (4) summary

pfam00520
Location:1296 → 1565

Ion_trans; Ion transport protein

pfam08763
Location:1638 → 1709

Ca_chan_IQ; Voltage gated calcium channel IQ domain

pfam16885
Location:1731 → 2166

CAC1F_C; Voltage-gated calcium channel subunit alpha, C-term

pfam16905
Location:1574 → 1627

GPHH; Voltage-dependent L-type calcium channel, IQ-associated
XM_036165771.1 → XP_036021664.1 voltage-dependent L-type calcium channel subunit alpha-1C isoform X3

UniProtKB/TrEMBL

C7TQ58

Conserved Domains (4) summary

pfam00520
Location:1296 → 1591

Ion_trans; Ion transport protein

pfam08763
Location:1664 → 1735

Ca_chan_IQ; Voltage gated calcium channel IQ domain

pfam16885
Location:1757 → 2192

CAC1F_C; Voltage-gated calcium channel subunit alpha, C-term

pfam16905
Location:1600 → 1653

GPHH; Voltage-dependent L-type calcium channel, IQ-associated
XM_036165773.1 → XP_036021666.1 voltage-dependent L-type calcium channel subunit alpha-1C isoform X5

UniProtKB/TrEMBL

C7TQ58

Conserved Domains (4) summary

pfam00520
Location:1296 → 1582

Ion_trans; Ion transport protein

pfam08763
Location:1655 → 1726

Ca_chan_IQ; Voltage gated calcium channel IQ domain

pfam16885
Location:1748 → 2183

CAC1F_C; Voltage-gated calcium channel subunit alpha, C-term

pfam16905
Location:1591 → 1644

GPHH; Voltage-dependent L-type calcium channel, IQ-associated
XM_036165769.1 → XP_036021662.1 voltage-dependent L-type calcium channel subunit alpha-1C isoform X1

UniProtKB/TrEMBL

C7TQ58

Conserved Domains (4) summary

pfam00520
Location:1296 → 1593

Ion_trans; Ion transport protein

pfam08763
Location:1666 → 1737

Ca_chan_IQ; Voltage gated calcium channel IQ domain

pfam16885
Location:1759 → 2194

CAC1F_C; Voltage-gated calcium channel subunit alpha, C-term

pfam16905
Location:1602 → 1655

GPHH; Voltage-dependent L-type calcium channel, IQ-associated
XM_036165778.1 → XP_036021671.1 voltage-dependent L-type calcium channel subunit alpha-1C isoform X15

UniProtKB/TrEMBL

A0A087WRM3

Conserved Domains (4) summary

pfam00520
Location:1266 → 1563

Ion_trans; Ion transport protein

pfam08763
Location:1636 → 1707

Ca_chan_IQ; Voltage gated calcium channel IQ domain

pfam16885
Location:1729 → 2164

CAC1F_C; Voltage-gated calcium channel subunit alpha, C-term

pfam16905
Location:1572 → 1625

GPHH; Voltage-dependent L-type calcium channel, IQ-associated
XM_030255126.2 → XP_030110986.1 voltage-dependent L-type calcium channel subunit alpha-1C isoform X40

Conserved Domains (4) summary

pfam00520
Location:492 → 789

Ion_trans; Ion transport protein

pfam08763
Location:862 → 933

Ca_chan_IQ; Voltage gated calcium channel IQ domain

pfam16885
Location:955 → 1392

CAC1F_C; Voltage-gated calcium channel subunit alpha, C-term

pfam16905
Location:798 → 851

GPHH; Voltage-dependent L-type calcium channel, IQ-associated
XM_011241193.3 → XP_011239495.1 voltage-dependent L-type calcium channel subunit alpha-1C isoform X42

UniProtKB/TrEMBL

C7TQ58

Related

ENSMUSP00000140415.2, ENSMUST00000188078.7

Conserved Domains (4) summary

pfam00520
Location:1251 → 1509

Ion_trans; Ion transport protein

pfam08763
Location:1582 → 1653

Ca_chan_IQ; Voltage gated calcium channel IQ domain

pfam16885
Location:1675 → 2112

CAC1F_C; Voltage-gated calcium channel subunit alpha, C-term

pfam16905
Location:1518 → 1571

GPHH; Voltage-dependent L-type calcium channel, IQ-associated
XM_011241192.3 → XP_011239494.1 voltage-dependent L-type calcium channel subunit alpha-1C isoform X41

UniProtKB/TrEMBL

C7TQ58

Related

ENSMUSP00000151863.2, ENSMUST00000219018.2

Conserved Domains (4) summary

pfam00520
Location:1251 → 1509

Ion_trans; Ion transport protein

pfam08763
Location:1582 → 1653

Ca_chan_IQ; Voltage gated calcium channel IQ domain

pfam16885
Location:1675 → 2112

CAC1F_C; Voltage-gated calcium channel subunit alpha, C-term

pfam16905
Location:1518 → 1571

GPHH; Voltage-dependent L-type calcium channel, IQ-associated