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    Stim2 stromal interaction molecule 2 [ Mus musculus (house mouse) ]

    Gene ID: 116873, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Stim2provided by MGI
    Official Full Name
    stromal interaction molecule 2provided by MGI
    Primary source
    MGI:MGI:2151156
    See related
    Ensembl:ENSMUSG00000039156 AllianceGenome:MGI:2151156
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to enable calcium channel regulator activity; calcium ion binding activity; and store-operated calcium channel activity. Predicted to be involved in activation of store-operated calcium channel activity; intracellular calcium ion homeostasis; and store-operated calcium entry. Predicted to be located in membrane. Predicted to be active in endoplasmic reticulum and plasma membrane. Is expressed in several structures, including adipose tissue; cardiovascular system; central nervous system; endocrine gland; and male reproductive gland or organ. Orthologous to human STIM2 (stromal interaction molecule 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in lung adult (RPKM 8.3), thymus adult (RPKM 7.1) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Stim2 in Genome Data Viewer
    Location:
    5 C1; 5 29.69 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (54155865..54278399)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (53998523..54121057)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_13097 Neighboring gene predicted gene, 40305 Neighboring gene predicted gene, 30601 Neighboring gene STARR-seq mESC enhancer starr_13098 Neighboring gene predicted gene, 52846 Neighboring gene STARR-seq mESC enhancer starr_13099 Neighboring gene STARR-seq mESC enhancer starr_13101 Neighboring gene STARR-seq mESC enhancer starr_13102 Neighboring gene predicted gene 10440 Neighboring gene crumbs homolog 1 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. STIM2 protects hippocampal mushroom spines from amyloid synaptotoxicity. Popugaeva E, et al. Mol Neurodegener, 2015 Aug 15. PMID 26275606, Free PMC Article
    2. STIM2 regulates both intracellular Ca(2+) distribution and Ca(2+) movement in skeletal myotubes. Oh MR, et al. Sci Rep, 2017 Dec 20. PMID 29263348, Free PMC Article
    3. STIM2 regulates AMPA receptor trafficking and plasticity at hippocampal synapses. Yap KA, et al. Neurobiol Learn Mem, 2017 Feb. PMID 27544849
    4. Presynaptic store-operated Ca(2+) entry drives excitatory spontaneous neurotransmission and augments endoplasmic reticulum stress. Chanaday NL, et al. Neuron, 2021 Apr 21. PMID 33711258, Free PMC Article
    5. Reduced synaptic STIM2 expression and impaired store-operated calcium entry cause destabilization of mature spines in mutant presenilin mice. Sun S, et al. Neuron, 2014 Apr 2. PMID 24698269, Free PMC Article

    See all (82) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Lack of Stim2 Affects Vision-Dependent Behavior and Sensitivity to Hypoxia.
      Title: Lack of Stim2 Affects Vision-Dependent Behavior and Sensitivity to Hypoxia.
    2. RGS10 physically and functionally interacts with STIM2 and requires store-operated calcium entry to regulate pro-inflammatory gene expression in microglia.
      Title: RGS10 physically and functionally interacts with STIM2 and requires store-operated calcium entry to regulate pro-inflammatory gene expression in microglia.
    3. Calsequestrin 1 Is an Active Partner of Stromal Interaction Molecule 2 in Skeletal Muscle.
      Title: Calsequestrin 1 Is an Active Partner of Stromal Interaction Molecule 2 in Skeletal Muscle.
    4. Mossy cell synaptic dysfunction causes memory imprecision via miR-128 inhibition of STIM2 in Alzheimer's disease mouse model.
      Title: Mossy cell synaptic dysfunction causes memory imprecision via miR-128 inhibition of STIM2 in Alzheimer's disease mouse model.
    5. Orai1 inhibitor STIM2beta regulates myogenesis by controlling SOCE dependent transcriptional factors.
      Title: Orai1 inhibitor STIM2β regulates myogenesis by controlling SOCE dependent transcriptional factors.
    6. These data indicate that STIM1 and STIM2 have differential roles in the production of IL-4, which are stimulus dependent. Furthermore, these results illustrate the vital role of STIM2 in basophils, which is often considered to be less important than STIM1.
      Title: Pivotal role of STIM2, but not STIM1, in IL-4 production by IL-3-stimulated murine basophils.
    7. mice deficient in both Stim1 and Stim2 in T cells (conditional double knockout [cDKO]) developed lymphoproliferative disorders and skin inflammation with a concomitant increase in serum IgG1 and IgE levels.
      Title: Stromal Interaction Molecule Deficiency in T Cells Promotes Spontaneous Follicular Helper T Cell Development and Causes Type 2 Immune Disorders.
    8. Results indicate that preformed clusters of STIM and ORAI1 enable local Ca(2+) entry events in unstimulated cells. Upon TCR activation, NAADP-evoked Ca(2+) release through RYR1, in coordination with Ca(2+) entry through ORAI1 and STIM, rapidly increases the number of Ca(2+) microdomains, thereby initiating spread of Ca(2+) signals deeper into the cytoplasm to promote full T cell activation.
      Title: ORAI1, STIM1/2, and RYR1 shape subsecond Ca(2+) microdomains upon T cell activation.
    9. data show that loss of SOCE in enamel cells has substantial detrimental effects on gene expression, cell function, and the mineralization of dental enamel
      Title: Store-operated Ca(2+) entry controls ameloblast cell function and enamel development.
    10. regulates both intracellular Ca2+ distribution and Ca2+ movement in skeletal myotubes
      Title: STIM2 regulates both intracellular Ca(2+) distribution and Ca(2+) movement in skeletal myotubes.
    Submit: New GeneRIF Correction See all GeneRIFs (28)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Gene trapped (1) 
    • Targeted (6)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables calcium channel regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium channel regulator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables calcium channel regulator activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables calcium ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables calcium ion binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables store-operated calcium channel activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables store-operated calcium channel activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in activation of store-operated calcium channel activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in activation of store-operated calcium channel activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in calcium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in intracellular calcium ion homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular calcium ion homeostasis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in intracellular calcium ion homeostasis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of calcium ion transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of calcium ion transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in store-operated calcium entry IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    stromal interaction molecule 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081103.2 → NP_001074572.2  stromal interaction molecule 2 isoform 2 precursor

      See identical proteins and their annotated locations for NP_001074572.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AC139037, AK173183, BF472598
      Consensus CDS
      CCDS39089.2
      UniProtKB/Swiss-Prot
      P83093, Q69ZI3, Q80VF4
      UniProtKB/TrEMBL
      A5CVE4, B2RQE3, B7ZN44
      Related
      ENSMUSP00000113174.3, ENSMUST00000117661.9
      Conserved Domains (3) summary
      cd09574
      Location:132 → 205
      SAM_STIM2; SAM domain of STIM2 subfamily proteins
      smart00454
      Location:133 → 197
      SAM; Sterile alpha motif
      pfam16533
      Location:348 → 445
      SOAR; STIM1 Orai1-activating region

    2. NM_001363348.1 → NP_001350277.1  stromal interaction molecule 2 isoform 1 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC139037, AC158152
      Consensus CDS
      CCDS89921.1
      UniProtKB/TrEMBL
      B2RQE3, B7ZN44, I1E4X8
      Related
      ENSMUSP00000143855.2, ENSMUST00000201469.4
      Conserved Domains (3) summary
      cd09574
      Location:132 → 205
      SAM_STIM2; SAM domain of STIM2 subfamily proteins
      pfam16533
      Location:348 → 453
      SOAR; STIM1 Orai1-activating region
      cl27055
      Location:250 → 430
      MutS_III; MutS domain III

    3. NM_054083.2 → NP_473424.2  stromal interaction molecule 2 isoform 3 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an alternate in-frame exon and uses an alternate in-frame splice junction compared to variant 1. The resulting isoform (3) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AC139037, AC158152, AK041804
      UniProtKB/TrEMBL
      B2RQE3, B7ZN44
      Conserved Domains (3) summary
      cd09574
      Location:132 → 205
      SAM_STIM2; SAM domain of STIM2 subfamily proteins
      pfam16533
      Location:348 → 416
      SOAR; STIM1 Orai1-activating region
      cl27055
      Location:250 → 340
      MutS_III; MutS domain III

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      54155865..54278399
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P83093.2 GenPept UniProtKB/Swiss-Prot:P83093

    Gene LinkOut

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