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    Garin1a golgi associated RAB2 interactor 1A [ Mus musculus (house mouse) ]

    Gene ID: 245884, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Garin1aprovided by MGI
    Official Full Name
    golgi associated RAB2 interactor 1Aprovided by MGI
    Primary source
    MGI:MGI:2141439
    See related
    Ensembl:ENSMUSG00000079652 AllianceGenome:MGI:2141439
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    GARI; Fam71f2
    Summary
    Involved in acrosome assembly. Located in Golgi apparatus. Orthologous to human GARIN1A (golgi associated RAB2 interactor 1A). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Restricted expression toward testis adult (RPKM 170.5) See more
    Orthologs
    human all
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    Genomic context

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    See Garin1a in Genome Data Viewer
    Location:
    6 A3.3; 6 12.36 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (29276298..29290684)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (29277528..29290684)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 40358 Neighboring gene STARR-positive B cell enhancer ABC_E4814 Neighboring gene hypoxia inducible lipid droplet associated Neighboring gene STARR-seq mESC enhancer starr_15437 Neighboring gene golgi associated RAB2 interactor 1B Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:29297688-29297797 Neighboring gene calumenin Neighboring gene opsin 1 (cone pigments), short-wave-sensitive (color blindness, tritan)

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. FAM71F1 binds to RAB2A and RAB2B and is essential for acrosome formation and male fertility in mice. Morohoshi A, et al. Development, 2021 Nov 1. PMID 34714330, Free PMC Article
    2. Large scale screening for novel rab effectors reveals unexpected broad Rab binding specificity. Fukuda M, et al. Mol Cell Proteomics, 2008 Jun. PMID 18256213
    3. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
    4. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in acrosome assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Golgi-associated RAB2 interactor protein 1A
    Names
    Golgi associated RAB2 interactor protein 1A
    Golgi-associated Rab2B interactor
    family with sequence similarity 71, member F2
    protein FAM71F2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001101486.2 → NP_001094956.1  Golgi-associated RAB2 interactor protein 1A isoform 1

      See identical proteins and their annotated locations for NP_001094956.1

      Status: VALIDATED

      Source sequence(s)
      AC044807, BC050974
      Consensus CDS
      CCDS51735.1
      UniProtKB/Swiss-Prot
      B2RXB0
      Related
      ENSMUSP00000110941.3, ENSMUST00000115286.4
      Conserved Domains (1) summary
      pfam12480
      Location:105 → 175
      DUF3699; Protein of unknown function (DUF3699)

    2. NM_001411706.1 → NP_001398635.1  Golgi-associated RAB2 interactor protein 1A isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC044807, AC079277

    RNA

    1. NR_156409.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC044807, AC079277
      Related
      ENSMUST00000167608.2

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      29276298..29290684
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011241060.4 → XP_011239362.1  Golgi-associated RAB2 interactor protein 1A isoform X1

      Conserved Domains (1) summary
      pfam12480
      Location:124 → 191
      DUF3699; Protein of unknown function (DUF3699)

    2. XM_011241061.4 → XP_011239363.1  Golgi-associated RAB2 interactor protein 1A isoform X2

      Conserved Domains (1) summary
      pfam12480
      Location:50 → 117
      DUF3699; Protein of unknown function (DUF3699)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    B2RXB0.1 GenPept UniProtKB/Swiss-Prot:B2RXB0

    Gene LinkOut

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