Slc7a10 solute carrier family 7 (cationic amino acid transporter, y+ system), member 10 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Slc7a10provided by MGI
Official Full Name: solute carrier family 7 (cationic amino acid transporter, y+ system), member 10provided by MGI
Primary source: MGI:MGI:1858261
See related: Ensembl:ENSMUSG00000030495 AllianceGenome:MGI:1858261
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Asc-1; D7Bwg0847e
Summary: Enables neutral L-amino acid transmembrane transporter activity. Involved in negative regulation of brown fat cell differentiation; neutral amino acid transport; and positive regulation of glycinergic synaptic transmission. Acts upstream of or within D-alanine transmembrane transport. Located in plasma membrane. Is expressed in brain; embryo mesenchyme; naris; and spinal cord ventricular layer. Orthologous to human SLC7A10 (solute carrier family 7 member 10). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in subcutaneous fat pad adult (RPKM 132.8), mammary gland adult (RPKM 77.6) and 7 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 B2; 7 21.13 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (34885520..34900539)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (35186095..35201116)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Impaired Adipocyte SLC7A10 Promotes Lipid Storage in Association With Insulin Resistance and Altered BCAA Metabolism.
Title: Impaired Adipocyte SLC7A10 Promotes Lipid Storage in Association With Insulin Resistance and Altered BCAA Metabolism.
Amino acid transporter Asc-1 (SLC7A10) expression is altered in basal ganglia in experimental Parkinsonism and L-dopa-induced dyskinesia model mice.
Title: Amino acid transporter Asc-1 (SLC7A10) expression is altered in basal ganglia in experimental Parkinsonism and L-dopa-induced dyskinesia model mice.
Role of the Neutral Amino Acid Transporter SLC7A10 in Adipocyte Lipid Storage, Obesity, and Insulin Resistance.
Title: Role of the Neutral Amino Acid Transporter SLC7A10 in Adipocyte Lipid Storage, Obesity, and Insulin Resistance.
Asc-1 regulates white versus beige adipocyte fate in a subcutaneous stromal cell population.
Title: Asc-1 regulates white versus beige adipocyte fate in a subcutaneous stromal cell population.
These results suggest a role of Asc-1 in modulating presynaptic glycine levels that can impact on the respiratory network.
Title: A neuronal role of the Alanine-Serine-Cysteine-1 transporter (SLC7A10, Asc-1) for glycine inhibitory transmission and respiratory pattern.
this study shows that the astrocytic transporter SLC7A10 mediates glycinergic inhibition of spinal cord motor neurons
Title: The astrocytic transporter SLC7A10 (Asc-1) mediates glycinergic inhibition of spinal cord motor neurons.
Asc-1 has a novel role in regulating NMDA receptor-dependent synaptic activity by mediating concurrent non-vesicular release of D-serine and glycine.
Title: Neuronal D-serine and glycine release via the Asc-1 transporter regulates NMDA receptor-dependent synaptic activity.
The alanine-serine-cysteine-1 (Asc-1) transporter controls glycine levels in the brain and is required for glycinergic inhibitory transmission
Title: The alanine-serine-cysteine-1 (Asc-1) transporter controls glycine levels in the brain and is required for glycinergic inhibitory transmission.
The amino acid transporter ASC-1 is a white adipocyte-specific cell surface protein.
Title: ASC-1, PAT2, and P2RX5 are cell surface markers for white, beige, and brown adipocytes.
The results presented reveal that Asc-1 is the only high affinity D-serine transporter in the mouse CNS and is the predominant mechanism for D-serine reuptake.
Title: Evidence from gene knockout studies implicates Asc-1 as the primary transporter mediating d-serine reuptake in the mouse CNS.

Submit: New GeneRIF Correction See all GeneRIFs (12)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (1) 1 citation

General gene information

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Markers

RH125508 (e-PCR)
- UniSTS:162326

D7Bwg0847e (e-PCR), detects polymorphism
- UniSTS:142663

Slc7a10 (e-PCR), detects polymorphism
- UniSTS:546023

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables L-amino acid transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables neutral L-amino acid transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables neutral L-amino acid transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables neutral L-amino acid transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in D-alanine transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within D-alanine transmembrane transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in D-serine transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within D-serine transmembrane transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in D-serine transmembrane transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in glycine transport	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of brown fat cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within neutral amino acid transport	IDA Inferred from Direct Assay more info	PubMed
involved_in neutral amino acid transport	IDA Inferred from Direct Assay more info	PubMed
involved_in neutral amino acid transport	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of synaptic transmission, glycinergic	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in apical dendrite	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	NAS Non-traceable Author Statement more info	PubMed

General protein information

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Preferred Names: asc-type amino acid transporter 1

Names: D-serine transporter; solute carrier family 7 member 10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_017394.4 → NP_059090.3 asc-type amino acid transporter 1

See identical proteins and their annotated locations for NP_059090.3

Status: VALIDATED

Source sequence(s)

AC150683, BC054765

Consensus CDS

CCDS21146.1

UniProtKB/Swiss-Prot

P63115, Q9CW25, Q9JMH8

UniProtKB/TrEMBL

Q8C0A7

Related

ENSMUSP00000001854.6, ENSMUST00000001854.12

Conserved Domains (1) summary

TIGR00911
Location:38 → 503

2A0308; L-type amino acid transporter

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000073.7 Reference GRCm39 C57BL/6J

Range

34885520..34900539

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030242780.1 → XP_030098640.1 asc-type amino acid transporter 1 isoform X1

UniProtKB/TrEMBL

Q8C0A7

Conserved Domains (1) summary

TIGR00911
Location:38 → 453

2A0308; L-type amino acid transporter
XM_006540197.5 → XP_006540260.1 asc-type amino acid transporter 1 isoform X2

Conserved Domains (1) summary

TIGR00911
Location:38 → 376

2A0308; L-type amino acid transporter
XM_030242782.1 → XP_030098642.1 asc-type amino acid transporter 1 isoform X3

Conserved Domains (1) summary

TIGR00911
Location:26 → 354

2A0308; L-type amino acid transporter