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    Ndufc1 NADH:ubiquinone oxidoreductase subunit C1 [ Mus musculus (house mouse) ]

    Gene ID: 66377, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ndufc1provided by MGI
    Official Full Name
    NADH:ubiquinone oxidoreductase subunit C1provided by MGI
    Primary source
    MGI:MGI:1913627
    See related
    Ensembl:ENSMUSG00000037152 AllianceGenome:MGI:1913627
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    KFYI; CI-KFYI; 2310016K22Rik
    Summary
    Predicted to be involved in mitochondrial respiratory chain complex I assembly. Located in mitochondrion. Orthologous to human NDUFC1 (NADH:ubiquinone oxidoreductase subunit C1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in heart adult (RPKM 91.1), testis adult (RPKM 62.3) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ndufc1 in Genome Data Viewer
    Location:
    3 C; 3 22.47 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (51312876..51323167, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (51405479..51408955, complement)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene mitochondria localized glutamic acid rich protein Neighboring gene STARR-seq mESC enhancer starr_07614 Neighboring gene predicted gene 9442 Neighboring gene STARR-positive B cell enhancer ABC_E11182 Neighboring gene predicted gene, 50622 Neighboring gene N(alpha)-acetyltransferase 15, NatA auxiliary subunit Neighboring gene STARR-positive B cell enhancer ABC_E2664 Neighboring gene RAB33B, member RAS oncogene family

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Yin Yang 1 Orchestrates a Metabolic Program Required for Both Neural Crest Development and Melanoma Formation. Varum S, et al. Cell Stem Cell, 2019 Apr 4. PMID 30951662
    2. Hnrnpk maintains chondrocytes survival and function during growth plate development via regulating Hif1α-glycolysis axis. Chen Y, et al. Cell Death Dis, 2022 Sep 20. PMID 36127325, Free PMC Article
    3. Region-specific expression of mitochondrial complex I genes during murine brain development. Wirtz S, et al. PLoS One, 2011 Apr 27. PMID 21556144, Free PMC Article
    4. Yin Yang 1 sustains biosynthetic demands during brain development in a stage-specific manner. Zurkirchen L, et al. Nat Commun, 2019 May 16. PMID 31097699, Free PMC Article
    5. SCAF1 drives the compositional diversity of mammalian respirasomes. Vercellino I, et al. Nat Struct Mol Biol, 2024 Jul. PMID 38575788

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC106656

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in aerobic respiration NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in mitochondrial respiratory chain complex I assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitochondrial respiratory chain complex I assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in proton motive force-driven mitochondrial ATP synthesis NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in mitochondrial inner membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrial inner membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion HDA PubMed 
    part_of respiratory chain complex I IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of respiratory chain complex I IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of respiratory chain complex I ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of respiratory chain complex I ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial
    Names
    NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 1
    NADH-ubiquinone oxidoreductase KFYI subunit
    complex I-KFYI

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_025523.2 → NP_079799.1  NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial precursor

      See identical proteins and their annotated locations for NP_079799.1

      Status: VALIDATED

      Source sequence(s)
      AC105966
      Consensus CDS
      CCDS38426.1
      UniProtKB/Swiss-Prot
      Q58DY9, Q9CQY9
      Related
      ENSMUSP00000038463.7, ENSMUST00000038108.12
      Conserved Domains (1) summary
      pfam15088
      Location:28 → 76
      NADH_dh_m_C1; NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      51312876..51323167 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036163226.1 → XP_036019119.1  NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial isoform X1

      UniProtKB/Swiss-Prot
      Q58DY9, Q9CQY9
      Conserved Domains (1) summary
      pfam15088
      Location:28 → 76
      NADH_dh_m_C1; NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9CQY9.1 GenPept UniProtKB/Swiss-Prot:Q9CQY9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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