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    Eppin epididymal peptidase inhibitor [ Mus musculus (house mouse) ]

    Gene ID: 75526, updated on 27-Nov-2024

    Summary

    Official Symbol
    Eppinprovided by MGI
    Official Full Name
    epididymal peptidase inhibitorprovided by MGI
    Primary source
    MGI:MGI:1922776
    See related
    Ensembl:ENSMUSG00000017733 AllianceGenome:MGI:1922776
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Spinlw1; 1700024E17Rik
    Summary
    Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to be involved in defense response to bacterium; negative regulation of flagellated sperm motility; and negative regulation of peptidase activity. Located in acrosomal vesicle. Is expressed in male reproductive gland or organ. Orthologous to human EPPIN-WFDC6 (EPPIN-WFDC6 readthrough) and EPPIN (epididymal peptidase inhibitor). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Restricted expression toward genital fat pad adult (RPKM 71.8) See more
    Orthologs
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    Genomic context

    See Eppin in Genome Data Viewer
    Location:
    2 H3; 2 85.21 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (164430263..164435491, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (164588343..164593571, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene serine peptidase inhibitor, Kunitz type, 3 Neighboring gene WAP four-disulfide core domain 6A Neighboring gene WAP four-disulfide core domain 8 Neighboring gene predicted gene, 25512 Neighboring gene WAP four-disulfide core domain 6B

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Pathways from PubChem

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
     
    enables serine-type endopeptidase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in defense response to bacterium ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of calcium ion import IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of flagellated sperm motility IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of flagellated sperm motility IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of peptidase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in acrosomal vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cell surface IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
     
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    part_of protein-containing complex IEA
    Inferred from Electronic Annotation
    more info
     
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    eppin
    Names
    epididymal protease inhibitor
    serine protease inhibitor-like with Kunitz and WAP domains 1
    serine protease inhibitor-like, with Kunitz and WAP domains 1 (eppin)

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_029325.2NP_083601.1  eppin precursor

      See identical proteins and their annotated locations for NP_083601.1

      Status: PROVISIONAL

      Source sequence(s)
      AK006296
      Consensus CDS
      CCDS17043.1
      UniProtKB/Swiss-Prot
      A2A5G9, Q9DA01
      Related
      ENSMUSP00000099389.2, ENSMUST00000103100.2
      Conserved Domains (2) summary
      pfam00014
      Location:76127
      Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
      pfam00095
      Location:3272
      WAP; WAP-type (Whey Acidic Protein) 'four-disulfide core'

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      164430263..164435491 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)