Arr3 arrestin 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Arr3provided by RGD
Official Full Name: arrestin 3provided by RGD
Primary source: RGD:621385
See related: EnsemblRapid:ENSRNOG00000002904 AllianceGenome:RGD:621385
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables protein domain specific binding activity. Predicted to be involved in negative regulation of signal transduction. Predicted to act upstream of or within endocytosis and regulation of protein phosphorylation. Predicted to be located in photoreceptor inner segment; photoreceptor outer segment; and synapse. Human ortholog(s) of this gene implicated in myopia. Orthologous to human ARR3 (arrestin 3). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Adrenal (RPKM 41.5), Lung (RPKM 38.9) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: Xq22

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	X	NC_086039.1 (69739959..69752300)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	X	NC_051356.1 (65699881..65712224)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	X	NC_005120.4 (70438590..70452140)

Chromosome X - NC_086039.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Structural mechanisms of the arrestin-3/JNK3 interactions have been reported.
Title: Structural Mechanism of the Arrestin-3/JNK3 Interaction.
In early hypertensive phenotype. arrestin3 expression is elevated in resistance arteries.
Title: Defining the roles of arrestin2 and arrestin3 in vasoconstrictor receptor desensitization in hypertension.
These data suggest cell type- and subcellular compartment-dependent differences in GRK/arrestin-mediated desensitization and signaling.
Title: Distinct cellular and subcellular distributions of G protein-coupled receptor kinase and arrestin isoforms in the striatum.
The effects of arrestin 2 and 3 depletion on endothelin type A and P2Y2 receptor mediated ERK and p38 MAPK signaling, as well as migratory responses are reported
Title: Arrestins 2 and 3 differentially regulate ETA and P2Y2 receptor-mediated cell signaling and migration in arterial smooth muscle.
mutant FSHR displays an approximately 4-fold enhancement in binding affinity for arrestin-3 and an approximately 1.7-fold reduction in maximal arrestin-3 binding capacity
Title: Identification of a short linear sequence present in the C-terminal tail of the rat follitropin receptor that modulates arrestin-3 binding in a phosphorylation-independent fashion.
Arrestin2 and arrestin3 in striatal homogenates bind to the third cytoplasmic loop of the D2 receptor.
Title: Preferential Interaction between the dopamine D2 receptor and Arrestin2 in neostriatal neurons.

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables opsin binding	IEA Inferred from Electronic Annotation more info
enables opsin binding	ISO Inferred from Sequence Orthology more info
enables phosphoprotein binding	IEA Inferred from Electronic Annotation more info
enables phosphoprotein binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein domain specific binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in endocytosis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within endocytosis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of signal transduction	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within regulation of protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in signal transduction	IEA Inferred from Electronic Annotation more info
involved_in visual perception	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in photoreceptor inner segment	IEA Inferred from Electronic Annotation more info
located_in photoreceptor inner segment	ISO Inferred from Sequence Orthology more info
located_in photoreceptor outer segment	IEA Inferred from Electronic Annotation more info
located_in photoreceptor outer segment	ISO Inferred from Sequence Orthology more info
located_in synapse	IEA Inferred from Electronic Annotation more info
located_in synapse	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: arrestin-C

Names: arrestin 3, retinal (X-arrestin); cArr; cone arrestin; retinal cone arrestin-3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001190993.1 → NP_001177922.1 arrestin-C

See identical proteins and their annotated locations for NP_001177922.1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000021

UniProtKB/TrEMBL

A6IQ79, F1LMR6

Related

ENSRNOP00000003946.4, ENSRNOT00000003946.6

Conserved Domains (2) summary

smart01017
Location:190 → 353

Arrestin_C; Arrestin (or S-antigen), C-terminal domain

pfam00339
Location:14 → 171

Arrestin_N; Arrestin (or S-antigen), N-terminal domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086039.1 Reference GRCr8

Range

69739959..69752300

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039099437.1 → XP_038955365.1 arrestin-C isoform X1

UniProtKB/TrEMBL

A6IQ79

Conserved Domains (2) summary

smart01017
Location:175 → 338

Arrestin_C; Arrestin (or S-antigen), C-terminal domain

cl22903
Location:33 → 154

Arrestin_N; Arrestin (or S-antigen), N-terminal domain