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    Arhgap20 Rho GTPase activating protein 20 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 367085, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Arhgap20provided by RGD
    Official Full Name
    Rho GTPase activating protein 20provided by RGD
    Primary source
    RGD:1303160
    See related
    EnsemblRapid:ENSRNOG00000025624 AllianceGenome:RGD:1303160
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RARhoGAP
    Summary
    Predicted to enable GTPase activator activity. Predicted to be involved in regulation of Rho protein signal transduction. Orthologous to human ARHGAP20 (Rho GTPase activating protein 20). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 79.8), Muscle (RPKM 66.4) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Arhgap20 in Genome Data Viewer
    Location:
    8q24
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (60970480..61055199)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (52074472..52155739)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (56179581..56264343)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene U4 spliceosomal RNA Neighboring gene uncharacterized LOC134480050 Neighboring gene ferredoxin 1 Neighboring gene mitochondrial ribosomal protein L1, pseudogene 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Identification of RARhoGAP, a novel putative RhoGAP gene expressed in male germ cells. Curry BJ, et al. Genomics, 2004 Aug. PMID 15234003
    2. A germline-specific class of small RNAs binds mammalian Piwi proteins. Girard A, et al. Nature, 2006 Jul 13. PMID 16751776
    3. Genome sequence of the Brown Norway rat yields insights into mammalian evolution. Gibbs RA, et al. Nature, 2004 Apr 1. PMID 15057822
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables small GTPase binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in regulation of Rho protein signal transduction TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    rho GTPase-activating protein 20
    Names
    RA and RhoGAP domain-containing protein
    RhoGTPase activating protein
    rho-type GTPase-activating protein 20

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001434330.1 → NP_001421259.1  rho GTPase-activating protein 20 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/Swiss-Prot
      Q6REY9
      UniProtKB/TrEMBL
      A6J4H7

    2. NM_001434331.1 → NP_001421260.1  rho GTPase-activating protein 20 isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008

    3. NM_001434332.1 → NP_001421261.1  rho GTPase-activating protein 20 isoform 4

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008

    4. NM_213629.3 → NP_998794.2  rho GTPase-activating protein 20 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/TrEMBL
      A6J4H7
      Conserved Domains (3) summary
      cd04402
      Location:326 → 519
      RhoGAP_ARHGAP20; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP20-like proteins. ArhGAP20, also known as KIAA1391 and RA-RhoGAP, contains a RhoGAP, a RA, and a PH domain, and ANXL repeats. ArhGAP20 is activated by Rap1 and induces ...
      cd13319
      Location:48 → 144
      PH_RARhoGAP; RA and RhoGAP domain-containing protein Pleckstrin homology PH domain
      cd17115
      Location:158 → 275
      RA_RHG20; Ras-associating (RA) domain found in Rho GTPase-activating protein 20 (RHG20) and similar proteins

    RNA

    1. NR_197774.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      60970480..61055199
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063265878.1 → XP_063121948.1  rho GTPase-activating protein 20 isoform X1

      Related
      ENSRNOP00000034071.3, ENSRNOT00000035989.7

    2. XM_063265879.1 → XP_063121949.1  rho GTPase-activating protein 20 isoform X2

    RNA

    1. XR_010054006.1 RNA Sequence

    2. XR_010054007.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6REY9.2 GenPept UniProtKB/Swiss-Prot:Q6REY9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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