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    Nek2 NIMA-related kinase 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 114482, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Nek2provided by RGD
    Official Full Name
    NIMA-related kinase 2provided by RGD
    Primary source
    RGD:619792
    See related
    EnsemblRapid:ENSRNOG00000004487 AllianceGenome:RGD:619792
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable protein kinase activity and protein phosphatase binding activity. Predicted to be involved in centrosome separation; protein autophosphorylation; and regulation of cell cycle process. Predicted to act upstream of or within several processes, including blastocyst development; mitotic spindle assembly; and positive regulation of telomere maintenance. Predicted to be located in several cellular components, including condensed chromosome; microtubule cytoskeleton; and midbody. Predicted to be part of protein-containing complex. Human ortholog(s) of this gene implicated in retinitis pigmentosa 67. Orthologous to human NEK2 (NIMA related kinase 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Testes (RPKM 473.5), Thymus (RPKM 131.1) and 2 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Nek2 in Genome Data Viewer
    Location:
    13q27
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (105936809..105950054)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (103405818..103419063)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (110511546..110524750)

    Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene lysophosphatidylglycerol acyltransferase 1 Neighboring gene uncharacterized LOC102555670 Neighboring gene uncharacterized LOC120096356 Neighboring gene solute carrier family 30 member 1 Neighboring gene uncharacterized LOC108352598

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Alternative splicing controls nuclear translocation of the cell cycle-regulated Nek2 kinase. Wu W, et al. J Biol Chem, 2007 Sep 7. PMID 17626005
    2. Suppression of Nek2A in mouse early embryos confirms its requirement for chromosome segregation. Sonn S, et al. J Cell Sci, 2004 Nov 1. PMID 15479717
    3. Nek2 localizes to multiple sites in mitotic cells, suggesting its involvement in multiple cellular functions during the cell cycle. Ha Kim Y, et al. Biochem Biophys Res Commun, 2002 Jan 18. PMID 11785960
    4. The mitotic checkpoint kinase NEK2A regulates kinetochore microtubule attachment stability. Du J, et al. Oncogene, 2008 Jul 3. PMID 18297113, Free PMC Article
    5. Phosphorylation of high-mobility group protein A2 by Nek2 kinase during the first meiotic division in mouse spermatocytes. Di Agostino S, et al. Mol Biol Cell, 2004 Mar. PMID 14668482, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein phosphatase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within blastocyst development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in centrosome separation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within chromosome segregation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in chromosome segregation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within mitotic sister chromatid segregation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within mitotic spindle assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of centriole-centriole cohesion ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of telomere maintenance ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein autophosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of attachment of spindle microtubules to kinetochore ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of mitotic centrosome separation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in condensed nuclear chromosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in kinetochore ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in midbody ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in spindle pole ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    serine/threonine-protein kinase Nek2
    Names
    NIMA (never in mitosis gene a)-related expressed kinase 2
    NIMA (never in mitosis gene a)-related kinase 2
    NP_446143.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053691.2 → NP_446143.1  serine/threonine-protein kinase Nek2

      Status: VALIDATED

      Source sequence(s)
      AF352021, EV771094, JAXUCZ010000013
      UniProtKB/TrEMBL
      A6JH03, G3V6L2
      Related
      ENSRNOP00000006235.3, ENSRNOT00000006235.7
      Conserved Domains (2) summary
      smart00220
      Location:8 → 271
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd08217
      Location:7 → 271
      STKc_Nek2; Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 2

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086031.1 Reference GRCr8

      Range
      105936809..105950054
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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