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    Slc48a1 solute carrier family 48 member 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 300191, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Slc48a1provided by RGD
    Official Full Name
    solute carrier family 48 member 1provided by RGD
    Primary source
    RGD:1562880
    See related
    EnsemblRapid:ENSRNOG00000053196 AllianceGenome:RGD:1562880
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Hrg1; HRG-1
    Summary
    Predicted to enable heme binding activity and heme transmembrane transporter activity. Predicted to be involved in several processes, including heme transport; localization of cell; and phagocytosis. Predicted to be located in endolysosome and endosome membrane. Predicted to be active in phagolysosome membrane and plasma membrane. Orthologous to human SLC48A1 (solute carrier family 48 member 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 321.8), Spleen (RPKM 317.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Slc48a1 in Genome Data Viewer
    Location:
    7q36
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (130794233..130802119)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (128915136..128923929)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (139271698..139279499)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134479568 Neighboring gene Rap guanine nucleotide exchange factor 3 Neighboring gene uncharacterized LOC102548155 Neighboring gene histone deacetylase 7 Neighboring gene uncharacterized LOC108351548 Neighboring gene uncharacterized LOC103692974

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Heme-binding protein HRG-1 is induced by insulin-like growth factor I and associates with the vacuolar H+-ATPase to control endosomal pH and receptor trafficking. O'Callaghan KM, et al. J Biol Chem, 2010 Jan 1. PMID 19875448, Free PMC Article
    2. Haem homeostasis is regulated by the conserved and concerted functions of HRG-1 proteins. Rajagopal A, et al. Nature, 2008 Jun 19. PMID 18418376, Free PMC Article
    3. HRG1 is essential for heme transport from the phagolysosome of macrophages during erythrophagocytosis. White C, et al. Cell Metab, 2013 Feb 5. PMID 23395172, Free PMC Article
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. HRG-1 regulates V-ATPase activity, which is essential for endosomal acidification, heme binding, and receptor trafficking in mammalian cells.
      Title: Heme-binding protein HRG-1 is induced by insulin-like growth factor I and associates with the vacuolar H+-ATPase to control endosomal pH and receptor trafficking.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC125237

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables heme binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables heme binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables heme transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables heme transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables heme transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of erythrocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in heme export ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in heme export from vacuole to cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in heme metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in heme transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in heme transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within heme transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in heme transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in localization of cell ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in lysosomal transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in phagocytosis ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endolysosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endosome membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endosome membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in lysosomal membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in lysosomal membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in lysosomal membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in phagocytic vesicle membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in phagolysosome membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    heme transporter HRG1
    Names
    Heme-responsive gene 1 protein homolog
    solute carrier family 48 (heme transporter), member 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001127456.1 → NP_001120928.1  heme transporter HRG1

      See identical proteins and their annotated locations for NP_001120928.1

      Status: PROVISIONAL

      Source sequence(s)
      BC158869
      UniProtKB/Swiss-Prot
      B0BNL4, Q3KR77
      UniProtKB/TrEMBL
      A0A8L2R3J2
      Related
      ENSRNOP00000077408.2, ENSRNOT00000105518.2
      Conserved Domains (1) summary
      pfam16954
      Location:72 → 122
      HRG; Haem-transporter, endosomal/lysosomal, haem-responsive gene

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      130794233..130802119
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039078912.2 → XP_038934840.1  heme transporter HRG1 isoform X1

      Conserved Domains (1) summary
      pfam16954
      Location:10 → 66
      HRG; Haem-transporter, endosomal/lysosomal, haem-responsive gene
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    B0BNL4.1 GenPept UniProtKB/Swiss-Prot:B0BNL4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools