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    Tnrc6b trinucleotide repeat containing adaptor 6B [ Rattus norvegicus (Norway rat) ]

    Gene ID: 192178, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Tnrc6bprovided by RGD
    Official Full Name
    trinucleotide repeat containing adaptor 6Bprovided by RGD
    Primary source
    RGD:621428
    See related
    EnsemblRapid:ENSRNOG00000024907 AllianceGenome:RGD:621428
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Cbl27
    Summary
    Predicted to enable RNA binding activity. Predicted to be involved in miRNA-mediated post-transcriptional gene silencing; positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay; and positive regulation of nuclear-transcribed mRNA poly(A) tail shortening. Predicted to act upstream of with a positive effect on miRNA-mediated gene silencing by inhibition of translation. Predicted to be located in cytosol. Predicted to be active in P-body and nucleoplasm. Human ortholog(s) of this gene implicated in subserous uterine fibroid and uterine fibroid. Orthologous to human TNRC6B (trinucleotide repeat containing adaptor 6B). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 154.8), Spleen (RPKM 143.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Tnrc6b in Genome Data Viewer
    Location:
    7q34
    Exon count:
    32
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (114132574..114350010)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (112252351..112469829)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (121930610..122147934)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene GRB2-related adaptor protein 2 Neighboring gene family with sequence similarity 83, member F Neighboring gene ribosomal protein L26, pseudogene 1 Neighboring gene uncharacterized LOC120093695 Neighboring gene ribosomal protein L29, pseudogene 1 Neighboring gene SREK1-interacting protein 1, pseudogene 1 Neighboring gene adenylosuccinate lyase Neighboring gene small G protein signaling modulator 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Variants in BET1L and TNRC6B associate with increasing fibroid volume and fibroid type among European Americans. Edwards TL, et al. Hum Genet, 2013 Dec. PMID 23892540, Free PMC Article
    2. Argonaute proteins at a glance. Ender C, et al. J Cell Sci, 2010 Jun 1. PMID 20484662
    3. Mammalian miRNA RISC recruits CAF1 and PABP to affect PABP-dependent deadenylation. Fabian MR, et al. Mol Cell, 2009 Sep 24. PMID 19716330, Free PMC Article
    4. RNF207 exacerbates pathological cardiac hypertrophy via post-translational modification of TAB1. Yuan L, et al. Cardiovasc Res, 2023 Mar 17. PMID 35352799
    5. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Castello A, et al. Cell, 2012 Jun 8. PMID 22658674

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    acts_upstream_of_positive_effect miRNA-mediated gene silencing by inhibition of translation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in miRNA-mediated post-transcriptional gene silencing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of nuclear-transcribed mRNA poly(A) tail shortening IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of nuclear-transcribed mRNA poly(A) tail shortening ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulatory ncRNA-mediated gene silencing ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in P-body IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    trinucleotide repeat-containing gene 6B protein
    Names
    androgen receptor-related apoptosis-associated protein CBL27
    trinucleotide repeat containing 6B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_138845.5 → NP_620200.2  trinucleotide repeat-containing gene 6B protein

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/TrEMBL
      A0A8I5ZQG5
      Related
      ENSRNOP00000079479.2, ENSRNOT00000102287.2
      Conserved Domains (3) summary
      cd12712
      Location:1632 → 1714
      RRM_TNRC6B; RNA recognition motif in vertebrate trinucleotide repeat-containing gene 6B protein (TNRC6B)
      pfam10427
      Location:979 → 1080
      Ago_hook; Argonaute hook
      pfam16608
      Location:1349 → 1630
      TNRC6-PABC_bdg; TNRC6-PABC binding domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      114132574..114350010
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039078367.2 → XP_038934295.1  trinucleotide repeat-containing gene 6B protein isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZQG5
      Conserved Domains (3) summary
      pfam10427
      Location:934 → 1076
      Ago_hook; Argonaute hook
      pfam16608
      Location:1384 → 1665
      TNRC6-PABC_bdg; TNRC6-PABC binding domain
      cd12712
      Location:1667 → 1749
      RRM_TNRC6B; RNA recognition motif (RRM) found in vertebrate trinucleotide repeat-containing gene 6B protein (TNRC6B)

    2. XM_063262963.1 → XP_063119033.1  trinucleotide repeat-containing gene 6B protein isoform X4

      UniProtKB/TrEMBL
      A0A8I5ZQG5

    3. XM_063262961.1 → XP_063119031.1  trinucleotide repeat-containing gene 6B protein isoform X1

      UniProtKB/TrEMBL
      A0A0G2K6R0, A0A8I5ZQG5
      Related
      ENSRNOP00000073908.2, ENSRNOT00000091270.3

    4. XM_063262966.1 → XP_063119036.1  trinucleotide repeat-containing gene 6B protein isoform X6

      UniProtKB/TrEMBL
      A0A8I5ZQG5

    5. XM_063262971.1 → XP_063119041.1  trinucleotide repeat-containing gene 6B protein isoform X11

      UniProtKB/TrEMBL
      A0A8I5ZQG5

    6. XM_063262965.1 → XP_063119035.1  trinucleotide repeat-containing gene 6B protein isoform X5

      UniProtKB/TrEMBL
      A0A8I5ZQG5

    7. XM_063262970.1 → XP_063119040.1  trinucleotide repeat-containing gene 6B protein isoform X10

      UniProtKB/TrEMBL
      A0A8I5ZQG5, F1LV37
      Related
      ENSRNOP00000036077.6, ENSRNOT00000033975.7

    8. XM_039078366.2 → XP_038934294.1  trinucleotide repeat-containing gene 6B protein isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZQG5
      Conserved Domains (3) summary
      pfam10427
      Location:934 → 1076
      Ago_hook; Argonaute hook
      pfam16608
      Location:1384 → 1665
      TNRC6-PABC_bdg; TNRC6-PABC binding domain
      cd12712
      Location:1667 → 1749
      RRM_TNRC6B; RNA recognition motif (RRM) found in vertebrate trinucleotide repeat-containing gene 6B protein (TNRC6B)

    9. XM_063262962.1 → XP_063119032.1  trinucleotide repeat-containing gene 6B protein isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZQG5

    10. XM_006242061.5 → XP_006242123.2  trinucleotide repeat-containing gene 6B protein isoform X3

      UniProtKB/TrEMBL
      A0A8I5ZQG5
      Related
      ENSRNOP00000080619.2, ENSRNOT00000106327.2

    11. XM_063262968.1 → XP_063119038.1  trinucleotide repeat-containing gene 6B protein isoform X8

      UniProtKB/TrEMBL
      A0A8I5ZQG5

    12. XM_063262969.1 → XP_063119039.1  trinucleotide repeat-containing gene 6B protein isoform X9

      UniProtKB/TrEMBL
      A0A8I5ZQG5, A0A8I6ADQ2

    13. XM_063262972.1 → XP_063119042.1  trinucleotide repeat-containing gene 6B protein isoform X12

      UniProtKB/TrEMBL
      A0A8I5ZQG5

    14. XM_063262964.1 → XP_063119034.1  trinucleotide repeat-containing gene 6B protein isoform X4

      UniProtKB/TrEMBL
      A0A8I5ZQG5

    15. XM_039078369.2 → XP_038934297.1  trinucleotide repeat-containing gene 6B protein isoform X7

      UniProtKB/TrEMBL
      A0A8I5ZQG5
      Conserved Domains (3) summary
      pfam10427
      Location:882 → 1024
      Ago_hook; Argonaute hook
      pfam16608
      Location:1332 → 1613
      TNRC6-PABC_bdg; TNRC6-PABC binding domain
      cd12712
      Location:1615 → 1697
      RRM_TNRC6B; RNA recognition motif (RRM) found in vertebrate trinucleotide repeat-containing gene 6B protein (TNRC6B)
    Nucleotide Protein Strain
    Heading Accession and Version

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