Dhx35 DEAH-box helicase 35 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Dhx35provided by RGD
Official Full Name: DEAH-box helicase 35provided by RGD
Primary source: RGD:1311165
See related: EnsemblRapid:ENSRNOG00000015928 AllianceGenome:RGD:1311165
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable RNA binding activity and helicase activity. Predicted to act upstream of or within in utero embryonic development. Predicted to be part of catalytic step 2 spliceosome. Orthologous to human DHX35 (DEAH-box helicase 35). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Heart (RPKM 61.8), Kidney (RPKM 55.2) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 3q42

Exon count:: 24

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (167869971..167927300)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (147450178..147507473)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (155297545..155354857)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables RNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA helicase activity	IEA Inferred from Electronic Annotation more info
enables helicase activity	IBA Inferred from Biological aspect of Ancestor more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within in utero embryonic development	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of catalytic step 2 spliceosome	IBA Inferred from Biological aspect of Ancestor more info
part_of catalytic step 2 spliceosome	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: probable ATP-dependent RNA helicase DHX35

Names: DEAH (Asp-Glu-Ala-His) box polypeptide 35

NP_001102071.1

EC 3.6.1.-

NP_001402786.1

EC 3.6.1.-

XP_017447419.1

EC 3.6.1.-

XP_038961441.1

EC 3.6.1.-

XP_063140258.1

EC 3.6.1.-

XP_063140259.1

EC 3.6.1.-

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001108601.2 → NP_001102071.1 probable ATP-dependent RNA helicase DHX35 isoform 2

See identical proteins and their annotated locations for NP_001102071.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000003

UniProtKB/TrEMBL

A6JWY0, A6JWY1, D4AEG5

Related

ENSRNOP00000021435.4, ENSRNOT00000021435.7

Conserved Domains (5) summary

smart00490
Location:301 → 396

HELICc; helicase superfamily c-terminal domain

smart00487
Location:53 → 224

DEXDc; DEAD-like helicases superfamily

smart00847
Location:465 → 549

HA2; Helicase associated domain (HA2) Add an annotation

cd00046
Location:73 → 211

DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.

pfam07717
Location:584 → 659

OB_NTP_bind; Oligonucleotide/oligosaccharide-binding (OB)-fold
NM_001415857.1 → NP_001402786.1 probable ATP-dependent RNA helicase DHX35 isoform 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000003

UniProtKB/TrEMBL

A0A0G2JTM6, A6JWY1

Related

ENSRNOP00000068770.1, ENSRNOT00000084866.3

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086021.1 Reference GRCr8

Range

167869971..167927300

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039105513.2 → XP_038961441.1 probable ATP-dependent RNA helicase DHX35 isoform X2

Conserved Domains (1) summary

COG1643
Location:21 → 407

HrpA; HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]
XM_063284189.1 → XP_063140259.1 probable ATP-dependent RNA helicase DHX35 isoform X1

UniProtKB/TrEMBL

A6JWY1
XM_063284188.1 → XP_063140258.1 probable ATP-dependent RNA helicase DHX35 isoform X1

UniProtKB/TrEMBL

A6JWY1
XM_017591930.3 → XP_017447419.1 probable ATP-dependent RNA helicase DHX35 isoform X1

UniProtKB/TrEMBL

A6JWY1

Conserved Domains (1) summary

COG1643
Location:1 → 527

HrpA; HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]