Il36a interleukin 36, alpha [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Il36aprovided by RGD
Official Full Name: interleukin 36, alphaprovided by RGD
Primary source: RGD:1306869
See related: EnsemblRapid:ENSRNOG00000005722 AllianceGenome:RGD:1306869
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Il1f6
Summary: Predicted to enable cytokine activity. Predicted to be involved in several processes, including cellular response to lipopolysaccharide; cytokine-mediated signaling pathway; and inflammatory response to antigenic stimulus. Predicted to act upstream of or within positive regulation of interleukin-6 production. Predicted to be active in extracellular space. Orthologous to human IL36A (interleukin 36 alpha). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Liver (RPKM 2.8), Lung (RPKM 1.2) and 4 other tissues See more
Orthologs: human all
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Genomic context

Location:: 3p13

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (27395146..27399695)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (6996851..7001400)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (1330790..1335811)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables cytokine activity	IBA Inferred from Biological aspect of Ancestor more info
enables cytokine activity	ISO Inferred from Sequence Orthology more info
enables interleukin-1 receptor binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cellular response to lipopolysaccharide	IBA Inferred from Biological aspect of Ancestor more info
involved_in cytokine production	IBA Inferred from Biological aspect of Ancestor more info
involved_in cytokine-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in inflammatory response	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of cytokine production	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of interleukin-6 production	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: interleukin-36 alpha

Names: interleukin 1 family, member 6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001106554.1 → NP_001100024.1 interleukin-36 alpha

See identical proteins and their annotated locations for NP_001100024.1

Status: PROVISIONAL

Source sequence(s)

CH474001

UniProtKB/TrEMBL

A6JSX7, D4A1I2

Related

ENSRNOP00000007540.4, ENSRNOT00000007540.7

Conserved Domains (1) summary

cl00094
Location:58 → 156

IL1; Interleukin-1 homologes; Cytokines with various biological functions. Interleukin 1 alpha and beta are also known as hematopoietin and catabolin. This family also contains interleukin-1 receptor antagonists (inhibitors).