Mpig6b megakaryocyte and platelet inhibitory receptor G6b [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Mpig6bprovided by RGD
Official Full Name: megakaryocyte and platelet inhibitory receptor G6bprovided by RGD
Primary source: RGD:1303269
See related: EnsemblRapid:ENSRNOG00000026936 AllianceGenome:RGD:1303269
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: G6b; Ng31; C6orf25
Summary: Predicted to enable heparin binding activity. Predicted to be involved in several processes, including blood coagulation; integrin-mediated signaling pathway; and myeloid cell differentiation. Predicted to be located in several cellular components, including Golgi apparatus; endoplasmic reticulum; and nucleoplasm. Predicted to be active in plasma membrane. Orthologous to human MPIG6B (megakaryocyte and platelet inhibitory receptor G6b). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Spleen (RPKM 9.5), Testes (RPKM 5.2) and 7 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 20p12

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	20	NC_086038.1 (3761832..3765679)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	20	NC_051355.1 (3757396..3761024)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	20	NC_005119.4 (5054419..5056655, complement)

Chromosome 20 - NC_086038.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables heparin binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in blood coagulation	IBA Inferred from Biological aspect of Ancestor more info
involved_in blood coagulation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within blood coagulation	ISO Inferred from Sequence Orthology more info
involved_in blood coagulation	ISS Inferred from Sequence or Structural Similarity more info
involved_in erythrocyte differentiation	IEA Inferred from Electronic Annotation more info
involved_in erythrocyte differentiation	ISO Inferred from Sequence Orthology more info
involved_in erythrocyte differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in integrin-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in integrin-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within integrin-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in integrin-mediated signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in megakaryocyte development	IBA Inferred from Biological aspect of Ancestor more info
involved_in megakaryocyte development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within megakaryocyte development	ISO Inferred from Sequence Orthology more info
involved_in megakaryocyte development	ISS Inferred from Sequence or Structural Similarity more info
involved_in megakaryocyte differentiation	ISO Inferred from Sequence Orthology more info
involved_in megakaryocyte differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of signal transduction	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of signal transduction	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of signal transduction	ISS Inferred from Sequence or Structural Similarity more info
involved_in platelet formation	IBA Inferred from Biological aspect of Ancestor more info
involved_in platelet formation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within platelet formation	ISO Inferred from Sequence Orthology more info
involved_in platelet formation	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: megakaryocyte and platelet inhibitory receptor G6b

Names: immunoreceptor tyrosine-based inhibitory motif (ITIM) containing platelet receptor; protein G6b

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001412137.2 → NP_001399066.1 megakaryocyte and platelet inhibitory receptor G6b precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000020

UniProtKB/Swiss-Prot

Q6MG59

UniProtKB/TrEMBL

A0A096MKA0, A6KTS3

Related

ENSRNOP00000068435.1, ENSRNOT00000076375.4

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086038.1 Reference GRCr8

Range

3761832..3765679

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063279382.1 → XP_063135452.1 megakaryocyte and platelet inhibitory receptor G6b isoform X1

UniProtKB/TrEMBL

A0A096MJK2

Related

ENSRNOP00000033088.3, ENSRNOT00000037191.5

RNA

XR_005497318.2 RNA Sequence
XR_005497316.2 RNA Sequence
XR_005497317.2 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001003976.1: Suppressed sequence

Description

NM_001003976.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.