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    Nrbf2 nuclear receptor binding factor 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 58839, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Nrbf2provided by RGD
    Official Full Name
    nuclear receptor binding factor 2provided by RGD
    Primary source
    RGD:61937
    See related
    EnsemblRapid:ENSRNOG00000000641 AllianceGenome:RGD:61937
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables nuclear receptor binding activity. Involved in positive regulation of DNA-templated transcription. Predicted to be located in cytoplasm. Predicted to be part of phosphatidylinositol 3-kinase complex, class III. Orthologous to human NRBF2 (nuclear receptor binding factor 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Liver (RPKM 175.4), Adrenal (RPKM 100.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Nrbf2 in Genome Data Viewer
    Location:
    20p11
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 20 NC_086038.1 (21307389..21325724)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (21308555..21326881)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (22728145..22746477)

    Chromosome 20 - NC_086038.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108349024 Neighboring gene uncharacterized LOC120098947 Neighboring gene U6 spliceosomal RNA Neighboring gene jumonji domain containing 1C Neighboring gene receptor accessory protein 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. NRBF2 regulates macroautophagy as a component of Vps34 Complex I. Cao Y, et al. Biochem J, 2014 Jul 15. PMID 24785657, Free PMC Article
    2. Nuclear receptor binding factor-2 (NRBF-2), a possible gene activator protein interacting with nuclear hormone receptors. Yasumo H, et al. Biochim Biophys Acta, 2000 Jan 31. PMID 10786636
    3. NRBF2 regulates autophagy and prevents liver injury by modulating Atg14L-linked phosphatidylinositol-3 kinase III activity. Lu J, et al. Nat Commun, 2014 May 22. PMID 24849286, Free PMC Article
    4. Structural Analysis of Hippocampal Kinase Signal Transduction. McClatchy DB, et al. ACS Chem Neurosci, 2018 Dec 19. PMID 30053369, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables nuclear receptor binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in autophagy IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in autophagy IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in autophagy ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of lipid kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to endoplasmic reticulum stress ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in autophagosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of phosphatidylinositol 3-kinase complex, class III ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    nuclear receptor-binding factor 2
    Names
    NRBF-2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_022186.3 → NP_071522.2  nuclear receptor-binding factor 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000020
      UniProtKB/Swiss-Prot
      Q9QYK3
      UniProtKB/TrEMBL
      A6JKW4, G3V622
      Related
      ENSRNOP00000000794.3, ENSRNOT00000000794.5
      Conserved Domains (2) summary
      pfam08961
      Location:89 → 284
      NRBF2; Nuclear receptor-binding factor 2, autophagy regulator
      pfam17169
      Location:4 → 86
      NRBF2_MIT; MIT domain of nuclear receptor-binding factor 2

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086038.1 Reference GRCr8

      Range
      21307389..21325724
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063279485.1 → XP_063135555.1  nuclear receptor-binding factor 2 isoform X2

      UniProtKB/Swiss-Prot
      Q9QYK3

    2. XM_063279484.1 → XP_063135554.1  nuclear receptor-binding factor 2 isoform X1

      UniProtKB/Swiss-Prot
      Q9QYK3
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9QYK3.1 GenPept UniProtKB/Swiss-Prot:Q9QYK3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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