Rnf125 ring finger protein 125 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Rnf125provided by RGD
Official Full Name: ring finger protein 125provided by RGD
Primary source: RGD:1306757
See related: EnsemblRapid:ENSRNOG00000057832 AllianceGenome:RGD:1306757
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable several functions, including p53 binding activity; ubiquitin conjugating enzyme binding activity; and zinc ion binding activity. Predicted to be involved in several processes, including negative regulation of RIG-I signaling pathway; negative regulation of type I interferon production; and protein polyubiquitination. Predicted to act upstream of or within cellular response to leukemia inhibitory factor. Predicted to be located in Golgi membrane. Predicted to be part of VCP-NPL4-UFD1 AAA ATPase complex. Orthologous to human RNF125 (ring finger protein 125). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Liver (RPKM 458.4), Lung (RPKM 136.4) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 18p12

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	18	NC_086036.1 (12528995..12550646)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	18	NC_051353.1 (12254066..12275719)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	18	NC_005117.4 (15193226..15225454, complement)

Chromosome 18 - NC_086036.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

RNF125, transcriptionally regulated by NFATC2, alleviates osteoarthritis via inhibiting the Wnt/beta-catenin signaling pathway through degrading TRIM14.
Title: RNF125, transcriptionally regulated by NFATC2, alleviates osteoarthritis via inhibiting the Wnt/β-catenin signaling pathway through degrading TRIM14.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables p53 binding	ISO Inferred from Sequence Orthology more info
enables ubiquitin conjugating enzyme binding	ISO Inferred from Sequence Orthology more info
enables ubiquitin protein ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin protein ligase activity	ISO Inferred from Sequence Orthology more info
enables ubiquitin-protein transferase activity	ISO Inferred from Sequence Orthology more info
enables zinc ion binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cellular response to leukemia inhibitory factor	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of RIG-I signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of type I interferon production	ISO Inferred from Sequence Orthology more info
involved_in protein polyubiquitination	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein polyubiquitination	ISO Inferred from Sequence Orthology more info
involved_in ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in ubiquitin-dependent protein catabolic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Golgi membrane	ISO Inferred from Sequence Orthology more info
part_of VCP-NPL4-UFD1 AAA ATPase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of VCP-NPL4-UFD1 AAA ATPase complex	ISO Inferred from Sequence Orthology more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: E3 ubiquitin-protein ligase RNF125

Names: ring finger protein 125, E3 ubiquitin protein ligase

NP_001101894.1

EC 2.3.2.27

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001108424.1 → NP_001101894.1 E3 ubiquitin-protein ligase RNF125

See identical proteins and their annotated locations for NP_001101894.1

Status: PROVISIONAL

Source sequence(s)

CH473974

UniProtKB/TrEMBL

A0A0G2JXY7, A0A8I5ZUW9, A0A9K3Y7V2, B1WCA3

Related

ENSRNOP00000082609.2, ENSRNOT00000095469.2

Conserved Domains (4) summary

cd00162
Location:37 → 76

RING_Ubox; RING-HC finger (C3HC4-type) [structural motif]

pfam05605
Location:142 → 174

zf-Di19; Drought induced 19 protein (Di19), zinc-binding

pfam18574
Location:95 → 127

zf_C2HC_14; C2HC Zing finger domain

cl17238
Location:35 → 77

RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain