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    Ccnb1ip1 cyclin B1 interacting protein 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 498492, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ccnb1ip1provided by RGD
    Official Full Name
    cyclin B1 interacting protein 1provided by RGD
    Primary source
    RGD:1561930
    See related
    EnsemblRapid:ENSRNOG00000026056 AllianceGenome:RGD:1561930
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable identical protein binding activity. Predicted to be involved in reciprocal meiotic recombination. Predicted to act upstream of or within blastocyst formation; chiasma assembly; and spermatid development. Predicted to be located in synaptonemal complex. Orthologous to human CCNB1IP1 (cyclin B1 interacting protein 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 21.9), Thymus (RPKM 18.7) and 2 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ccnb1ip1 in Genome Data Viewer
    Location:
    15p14
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (26488462..26504167, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (24014905..24031357, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (27720220..27736528, complement)

    Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene olfactory receptor family 11 subfamily H member 4 Neighboring gene tetratricopeptide repeat domain 5 Neighboring gene small nucleolar RNA SNORD126 Neighboring gene poly (ADP-ribose) polymerase 2 Neighboring gene ribonuclease P RNA component H1 Neighboring gene telomerase associated protein 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Antagonistic roles of ubiquitin ligase HEI10 and SUMO ligase RNF212 regulate meiotic recombination. Qiao H, et al. Nat Genet, 2014 Feb. PMID 24390283, Free PMC Article
    2. Mutation in mouse hei10, an e3 ubiquitin ligase, disrupts meiotic crossing over. Ward JO, et al. PLoS Genet, 2007 Aug. PMID 17784788, Free PMC Article
    3. Mammalian CNTD1 is critical for meiotic crossover maturation and deselection of excess precrossover sites. Holloway JK, et al. J Cell Biol, 2014 Jun 9. PMID 24891606, Free PMC Article
    4. Extensive disruption of protein interactions by genetic variants across the allele frequency spectrum in human populations. Fragoza R, et al. Nat Commun, 2019 Sep 12. PMID 31515488, Free PMC Article
    5. Towards a proteome-scale map of the human protein-protein interaction network. Rual JF, et al. Nature, 2005 Oct 20. PMID 16189514

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin protein ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within blastocyst formation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within chiasma assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in chiasma assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in reciprocal meiotic recombination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in reciprocal meiotic recombination ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within spermatid development ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in condensed nuclear chromosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in synaptonemal complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    E3 ubiquitin-protein ligase CCNB1IP1
    Names
    cyclin B1 interacting protein 1, E3 ubiquitin protein ligase
    NP_001020312.1
    XP_006251966.1
    XP_038949511.1
    XP_038949513.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001025141.1 → NP_001020312.1  E3 ubiquitin-protein ligase CCNB1IP1

      See identical proteins and their annotated locations for NP_001020312.1

      Status: VALIDATED

      Source sequence(s)
      BC091423
      UniProtKB/TrEMBL
      F7ETK5, Q5BJM2
      Related
      ENSRNOP00000031347.4, ENSRNOT00000029488.6
      Conserved Domains (2) summary
      smart00935
      Location:100 → 175
      OmpH; Outer membrane protein (OmpH-like)
      pfam14634
      Location:10 → 52
      zf-RING_5; zinc-RING finger domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086033.1 Reference GRCr8

      Range
      26488462..26504167 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039093585.2 → XP_038949513.1  E3 ubiquitin-protein ligase CCNB1IP1 isoform X3

      Conserved Domains (1) summary
      smart00935
      Location:45 → 122
      OmpH; Outer membrane protein (OmpH-like)

    2. XM_039093583.2 → XP_038949511.1  E3 ubiquitin-protein ligase CCNB1IP1 isoform X1

      UniProtKB/TrEMBL
      F7ETK5
      Related
      ENSRNOP00000112139.1, ENSRNOT00000128504.1
      Conserved Domains (2) summary
      smart00935
      Location:132 → 207
      OmpH; Outer membrane protein (OmpH-like)
      pfam14634
      Location:42 → 84
      zf-RING_5; zinc-RING finger domain

    3. XM_006251904.3 → XP_006251966.1  E3 ubiquitin-protein ligase CCNB1IP1 isoform X2

      See identical proteins and their annotated locations for XP_006251966.1

      UniProtKB/TrEMBL
      F7ETK5, Q5BJM2
      Conserved Domains (2) summary
      smart00935
      Location:100 → 175
      OmpH; Outer membrane protein (OmpH-like)
      pfam14634
      Location:10 → 52
      zf-RING_5; zinc-RING finger domain
    Nucleotide Protein Strain
    Heading Accession and Version

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