Epha5 EPH receptor A5 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Epha5provided by RGD
Official Full Name: EPH receptor A5provided by RGD
Primary source: RGD:620831
See related: EnsemblRapid:ENSRNOG00000002024 AllianceGenome:RGD:620831
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Els1; EHK-1; Els1.
Summary: Enables ephrin receptor activity and growth factor binding activity. Involved in several processes, including cAMP-mediated signaling; dendritic spine morphogenesis; and ephrin receptor signaling pathway. Acts upstream of or within negative regulation of cell adhesion. Located in axon and plasma membrane. Orthologous to human EPHA5 (EPH receptor A5). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 132.9) and Adrenal (RPKM 8.7) See more
Orthologs: human mouse all
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Genomic context

Location:: 14p21

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	14	NC_086032.1 (24007400..24374854)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	14	NC_051349.1 (23653393..24020129)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	14	NC_005113.4 (25589312..25958258)

Chromosome 14 - NC_086032.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

c-fos overexpression could upregulate EphA5 expression in hippocampal neurons of rats with congenital hypothyroidism.
Title: c-Fos downregulation positively regulates EphA5 expression in a congenital hypothyroidism rat model.
Downregulation of ephrinA5 and EphA5 in the CA3 region of the hippocampus may participate in the mechanism of mossy fiber sprouting and is closely associated with the development and progression of epilepsy.
Title: [Changes in the expression of EphA5/ephrinA5 in the CA3 region of the hippocampus in rats with epilepsy and their role in the pathogenesis of temporal lobe epilepsy].
EphA5 promoter methylation in the hippocampus of rats with congenital hypothyroidism is associated with the levels of EphA5 expression.
Title: DNA Methylation of the EphA5 Promoter Is Associated with Rat Congenital Hypothyroidism.
changes in ephrinA5/EphA5 interactions and synaptic plasticity within the ventromedial hypothalamus may contribute to the impairment in glucagon secretion and counterregulatory responses caused by recurrent hypoglycemia.
Title: Role of synaptic plasticity and EphA5-ephrinA5 interaction within the ventromedial hypothalamus in response to recurrent hypoglycemia.
ephrin-A5 and EphA5 signals play a necessary, activity-independent role in the initiation of the early phases of synaptogenesis
Title: Ephrin-A5 and EphA5 interaction induces synaptogenesis during early hippocampal development.

Submit: New GeneRIF Correction

General gene information

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Markers

UniSTS:495883 (e-PCR)
- UniSTS:495883

Epha5 (e-PCR), detects polymorphism
- UniSTS:495883

D14Hmgc6 (e-PCR)
- UniSTS:463390

RH131857 (e-PCR)
- UniSTS:215140

AW531504 (e-PCR)
- UniSTS:245114

BE110064 (e-PCR)
- UniSTS:245173

UniSTS:266988 (e-PCR)
- UniSTS:266988

Epha5 (e-PCR), detects polymorphism
- UniSTS:266988

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables GPI-linked ephrin receptor activity	IEA Inferred from Electronic Annotation more info
enables GPI-linked ephrin receptor activity	ISO Inferred from Sequence Orthology more info
enables GPI-linked ephrin receptor activity	ISS Inferred from Sequence or Structural Similarity more info
enables boss receptor activity	IEA Inferred from Electronic Annotation more info
enables brain-derived neurotrophic factor receptor activity	IEA Inferred from Electronic Annotation more info
enables ephrin receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables ephrin receptor activity	IEA Inferred from Electronic Annotation more info
enables epidermal growth factor receptor activity	IEA Inferred from Electronic Annotation more info
enables fibroblast growth factor receptor activity	IEA Inferred from Electronic Annotation more info
enables growth factor binding	IPI Inferred from Physical Interaction more info	PubMed
enables hepatocyte growth factor receptor activity	IEA Inferred from Electronic Annotation more info
enables histone H2AXY142 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3Y41 kinase activity	IEA Inferred from Electronic Annotation more info
enables insulin receptor activity	IEA Inferred from Electronic Annotation more info
enables insulin-like growth factor receptor activity	IEA Inferred from Electronic Annotation more info
enables macrophage colony-stimulating factor receptor activity	IEA Inferred from Electronic Annotation more info
enables placental growth factor receptor activity	IEA Inferred from Electronic Annotation more info
enables platelet-derived growth factor alpha-receptor activity	IEA Inferred from Electronic Annotation more info
enables platelet-derived growth factor beta-receptor activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein tyrosine kinase collagen receptor activity	IEA Inferred from Electronic Annotation more info
enables stem cell factor receptor activity	IEA Inferred from Electronic Annotation more info
enables transmembrane-ephrin receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables transmembrane-ephrin receptor activity	IEA Inferred from Electronic Annotation more info
enables vascular endothelial growth factor receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in Kit signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in axon guidance	IBA Inferred from Biological aspect of Ancestor more info
involved_in axon guidance	ISO Inferred from Sequence Orthology more info
involved_in axon guidance	ISS Inferred from Sequence or Structural Similarity more info
involved_in brain-derived neurotrophic factor receptor signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cellular response to follicle-stimulating hormone stimulus	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cellular response to forskolin	ISO Inferred from Sequence Orthology more info
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in collagen-activated tyrosine kinase receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in dendritic spine morphogenesis	IDA Inferred from Direct Assay more info	PubMed
involved_in ephrin receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in ephrin receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in ephrin receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in ephrin receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in epidermal growth factor receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in fibroblast growth factor receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in hepatocyte growth factor receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in hippocampus development	ISO Inferred from Sequence Orthology more info
involved_in hippocampus development	ISS Inferred from Sequence or Structural Similarity more info
involved_in insulin receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in insulin-like growth factor receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in macrophage colony-stimulating factor signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of cell adhesion	IDA Inferred from Direct Assay more info	PubMed
involved_in neuron development	ISO Inferred from Sequence Orthology more info
involved_in platelet-derived growth factor receptor-alpha signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in platelet-derived growth factor receptor-beta signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of CREB transcription factor activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of actin cytoskeleton organization	ISO Inferred from Sequence Orthology more info
involved_in regulation of actin cytoskeleton organization	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of insulin secretion involved in cellular response to glucose stimulus	ISO Inferred from Sequence Orthology more info
involved_in regulation of insulin secretion involved in cellular response to glucose stimulus	ISS Inferred from Sequence or Structural Similarity more info
involved_in vascular endothelial growth factor receptor-1 signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in vascular endothelial growth factor signaling pathway	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in adherens junction	ISO Inferred from Sequence Orthology more info
located_in axon	IDA Inferred from Direct Assay more info	PubMed
located_in cell periphery	ISO Inferred from Sequence Orthology more info
is_active_in dendrite	IBA Inferred from Biological aspect of Ancestor more info
located_in dendrite	ISO Inferred from Sequence Orthology more info
located_in dendrite	ISS Inferred from Sequence or Structural Similarity more info
located_in external side of plasma membrane	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in rough endoplasmic reticulum	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: ephrin type-A receptor 5

Names: EPH homology kinase 1; eck-like sequence 1; tyrosine-protein kinase receptor EHK-1

NP_001162608.1

EC 2.7.10.1

NP_077343.1

EC 2.7.10.1

XP_063129722.1

EC 2.7.10.1

XP_063129723.1

EC 2.7.10.1

XP_063129724.1

EC 2.7.10.1

XP_063129725.1

EC 2.7.10.1

XP_063129726.1

EC 2.7.10.1

XP_063129727.1

EC 2.7.10.1

XP_063129729.1

EC 2.7.10.1

XP_063129730.1

EC 2.7.10.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001169137.3 → NP_001162608.1 ephrin type-A receptor 5 isoform 1 precursor

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

JAXUCZ010000014

UniProtKB/Swiss-Prot

P54757

Conserved Domains (7) summary

cd09546
Location:967 → 1032

SAM_EPH-A5; SAM domain of EPH-A5 subfamily of tyrosine kinase receptors

smart00454
Location:971 → 1029

SAM; Sterile alpha motif

cd00063
Location:471 → 561

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd05066
Location:672 → 938

PTKc_EphR_A; Catalytic domain of the Protein Tyrosine Kinases, Class EphA Ephrin Receptors

pfam07714
Location:677 → 934

Pkinase_Tyr; Protein tyrosine kinase

pfam14575
Location:580 → 672

EphA2_TM; Ephrin type-A receptor 2 transmembrane domain

cl02704
Location:62 → 234

EphR_LBD; Ligand Binding Domain of Ephrin Receptors
NM_024367.2 → NP_077343.1 ephrin type-A receptor 5 isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an alternate in-frame exon in the central coding region and uses an alternate splice pattern in the 3' coding region, compared to variant 1. The resulting isoform (2) lacks an internal segment and has a shorter and distinct C-terminus, compared to isoform 1.

Source sequence(s)

JAXUCZ010000014

UniProtKB/TrEMBL

D3ZCV9

Conserved Domains (5) summary

cd00063
Location:359 → 449

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd05066
Location:560 → 826

PTKc_EphR_A; Catalytic domain of the Protein Tyrosine Kinases, Class EphA Ephrin Receptors

pfam14575
Location:464 → 562

EphA2_TM; Ephrin type-A receptor 2 transmembrane domain

cl02704
Location:62 → 234

EphR_LBD; Ligand Binding Domain of Ephrin Receptors

cl15755
Location:855 → 893

SAM_superfamily; SAM (Sterile alpha motif )