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    Mmp17 matrix metallopeptidase 17 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 288626, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Mmp17provided by RGD
    Official Full Name
    matrix metallopeptidase 17provided by RGD
    Primary source
    RGD:1311541
    See related
    EnsemblRapid:ENSRNOG00000023643 AllianceGenome:RGD:1311541
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable metalloendopeptidase activity. Predicted to be involved in collagen catabolic process and extracellular matrix organization. Predicted to act upstream of or within drinking behavior and kidney development. Predicted to be located in extracellular matrix. Predicted to be active in extracellular space. Orthologous to human MMP17 (matrix metallopeptidase 17). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 73.6), Uterus (RPKM 27.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Mmp17 in Genome Data Viewer
    Location:
    12q13
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (32710504..32735418, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (27074398..27099317, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (30701900..30728683, complement) , (30353874..30356526, complement)

    Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene 40S ribosomal protein S25 pseudogene Neighboring gene zinc finger protein 11 Neighboring gene uncharacterized LOC120095935 Neighboring gene splicing factor SWAP Neighboring gene uncharacterized LOC134481178 Neighboring gene uncharacterized LOC102555340

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. GPR18 is required for a normal CD8αα intestinal intraepithelial lymphocyte compartment. Wang X, et al. J Exp Med, 2014 Nov 17. PMID 25348153, Free PMC Article
    2. Genome sequence of the Brown Norway rat yields insights into mammalian evolution. Gibbs RA, et al. Nature, 2004 Apr 1. PMID 15057822
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables metalloendopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in collagen catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within drinking behavior ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in extracellular matrix organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within kidney development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular matrix IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    matrix metalloproteinase-17
    Names
    matrix metalloproteinase 17
    NP_001099395.1
    XP_063127237.1
    XP_063127238.1
    XP_063127239.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001105925.1 → NP_001099395.1  matrix metalloproteinase-17 precursor

      See identical proteins and their annotated locations for NP_001099395.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473973
      UniProtKB/TrEMBL
      A6J0R3, D3ZXJ0
      Related
      ENSRNOP00000037549.5, ENSRNOT00000035881.7
      Conserved Domains (4) summary
      cd00094
      Location:333 → 527
      HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...
      cd04278
      Location:131 → 294
      ZnMc_MMP; Zinc-dependent metalloprotease, matrix metalloproteinase (MMP) sub-family. MMPs are responsible for a great deal of pericellular proteolysis of extracellular matrix and cell surface molecules, playing crucial roles in morphogenesis, cell fate ...
      pfam00413
      Location:131 → 294
      Peptidase_M10; Matrixin
      pfam01471
      Location:44 → 104
      PG_binding_1; Putative peptidoglycan binding domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086030.1 Reference GRCr8

      Range
      32710504..32735418 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063271167.1 → XP_063127237.1  matrix metalloproteinase-17 isoform X1

    2. XM_063271169.1 → XP_063127239.1  matrix metalloproteinase-17 isoform X3

    3. XM_063271168.1 → XP_063127238.1  matrix metalloproteinase-17 isoform X2

    RNA

    1. XR_010056375.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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