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    Rhot1 ras homolog family member T1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 303351, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Rhot1provided by RGD
    Official Full Name
    ras homolog family member T1provided by RGD
    Primary source
    RGD:1307023
    See related
    EnsemblRapid:ENSRNOG00000004093 AllianceGenome:RGD:1307023
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable GTP binding activity and GTPase activity. Involved in establishment of mitochondrion localization by microtubule attachment; regulation of neurotransmitter secretion; and regulation of organelle transport along microtubule. Predicted to be located in mitochondrion. Predicted to be active in mitochondrial outer membrane. Orthologous to human RHOT1 (ras homolog family member T1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 280.7), Adrenal (RPKM 216.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Rhot1 in Genome Data Viewer
    Location:
    10q25-q26
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (65685687..65760682)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (65198700..65262807)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (67559277..67640622)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134480832 Neighboring gene transfer RNA alanine (anticodon CGC) Neighboring gene ring finger protein 135 Neighboring gene rhomboid like 3 Neighboring gene similar to human chromosome 17 open reading frame 75

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Circular RNA RHOT1 Regulates miR-142-5p/CCND1 to Participate in Chondrocyte Autophagy and Proliferation in Osteoarthritis. Man G, et al. J Immunol Res, 2022. PMID 35300071, Free PMC Article
    2. Brain-derived neurotrophic factor (BDNF)-induced mitochondrial motility arrest and presynaptic docking contribute to BDNF-enhanced synaptic transmission. Su B, et al. J Biol Chem, 2014 Jan 17. PMID 24302729, Free PMC Article
    3. Deacetylation of Miro1 by HDAC6 blocks mitochondrial transport and mediates axon growth inhibition. Kalinski AL, et al. J Cell Biol, 2019 Jun 3. PMID 31068376, Free PMC Article
    4. GTPase dependent recruitment of Grif-1 by Miro1 regulates mitochondrial trafficking in hippocampal neurons. MacAskill AF, et al. Mol Cell Neurosci, 2009 Mar. PMID 19103291
    5. Bidirectional Ca2+-dependent control of mitochondrial dynamics by the Miro GTPase. Saotome M, et al. Proc Natl Acad Sci U S A, 2008 Dec 30. PMID 19098100, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Circular RNA RHOT1 Regulates miR-142-5p/CCND1 to Participate in Chondrocyte Autophagy and Proliferation in Osteoarthritis.
      Title: Circular RNA RHOT1 Regulates miR-142-5p/CCND1 to Participate in Chondrocyte Autophagy and Proliferation in Osteoarthritis.
    2. The data point to HDAC6-dependent deacetylation of Miro1 as a mediator of axon growth inhibition through decreased mitochondrial transport.
      Title: Deacetylation of Miro1 by HDAC6 blocks mitochondrial transport and mediates axon growth inhibition.
    3. These data suggest that Miro1 and the kinesin adaptor Grif-1 play an important role in regulating mitochondrial transport in neurons.
      Title: GTPase dependent recruitment of Grif-1 by Miro1 regulates mitochondrial trafficking in hippocampal neurons.
    4. Miro proteins serve as a [Ca(2+)](c)-sensitive switch and bifunctional regulator for both the motility and fusion-fission dynamics of the mitochondria.
      Title: Bidirectional Ca2+-dependent control of mitochondrial dynamics by the Miro GTPase.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC156790

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cellular homeostasis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in establishment of mitochondrion localization by microtubule attachment IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in innate immune response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitochondrial outer membrane permeabilization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitochondrion transport along microtubule ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of mitochondrion organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of neurotransmitter secretion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of organelle transport along microtubule IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in mitochondrial outer membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    mitochondrial Rho GTPase 1
    Names
    ras homolog gene family, member T1
    NP_001100496.1
    XP_017452795.1
    XP_038941952.1
    XP_038941953.1
    XP_063125144.1
    XP_063125145.1
    XP_063125146.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107026.2 → NP_001100496.1  mitochondrial Rho GTPase 1

      See identical proteins and their annotated locations for NP_001100496.1

      Status: PROVISIONAL

      Source sequence(s)
      BC129123
      UniProtKB/TrEMBL
      A1L1L6, F7EK49
      Related
      ENSRNOP00000107396.1, ENSRNOT00000137581.1
      Conserved Domains (4) summary
      cd01892
      Location:428 → 605
      Miro2; Mitochondrial Rho family 2 (Miro2), C-terminal
      cd01893
      Location:16 → 182
      Miro1; Mitochondrial Rho family 1 (Miro1), N-terminal
      pfam08355
      Location:354 → 423
      EF_assoc_1; EF hand associated
      pfam08356
      Location:232 → 316
      EF_assoc_2; EF hand associated

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      65685687..65760682
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063269076.1 → XP_063125146.1  mitochondrial Rho GTPase 1 isoform X3

      UniProtKB/TrEMBL
      A0A8I6AMM4

    2. XM_063269074.1 → XP_063125144.1  mitochondrial Rho GTPase 1 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K777, F7EK49
      Related
      ENSRNOP00000074094.1, ENSRNOT00000082685.3

    3. XM_017597306.3 → XP_017452795.1  mitochondrial Rho GTPase 1 isoform X4

      UniProtKB/TrEMBL
      A0A8I6AVD9, F7EK49
      Related
      ENSRNOP00000097730.1, ENSRNOT00000112911.2
      Conserved Domains (4) summary
      cd01892
      Location:428 → 593
      Miro2; Mitochondrial Rho family 2 (Miro2), C-terminal
      cd01893
      Location:16 → 182
      Miro1; Mitochondrial Rho family 1 (Miro1), N-terminal
      pfam08355
      Location:354 → 423
      EF_assoc_1; EF hand associated
      pfam08356
      Location:232 → 316
      EF_assoc_2; EF hand associated

    4. XM_039086025.2 → XP_038941953.1  mitochondrial Rho GTPase 1 isoform X6

      UniProtKB/TrEMBL
      A0A0G2K8T2, F7EK49
      Related
      ENSRNOP00000074726.2, ENSRNOT00000079696.3
      Conserved Domains (4) summary
      cd01892
      Location:428 → 593
      Miro2; Mitochondrial Rho family 2 (Miro2), C-terminal
      cd01893
      Location:16 → 182
      Miro1; Mitochondrial Rho family 1 (Miro1), N-terminal
      pfam08355
      Location:354 → 423
      EF_assoc_1; EF hand associated
      pfam08356
      Location:232 → 316
      EF_assoc_2; EF hand associated

    5. XM_063269075.1 → XP_063125145.1  mitochondrial Rho GTPase 1 isoform X2

      UniProtKB/TrEMBL
      F7EK49
      Related
      ENSRNOP00000092578.2, ENSRNOT00000108985.2

    6. XM_039086024.2 → XP_038941952.1  mitochondrial Rho GTPase 1 isoform X5

      UniProtKB/TrEMBL
      A0A8I6AGU0, A6HHA9, F7EK49
      Conserved Domains (4) summary
      cd01892
      Location:428 → 594
      Miro2; Mitochondrial Rho family 2 (Miro2), C-terminal
      cd01893
      Location:16 → 182
      Miro1; Mitochondrial Rho family 1 (Miro1), N-terminal
      pfam08355
      Location:354 → 423
      EF_assoc_1; EF hand associated
      pfam08356
      Location:232 → 316
      EF_assoc_2; EF hand associated
    Nucleotide Protein Strain
    Heading Accession and Version

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