Cetn1 centrin 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cetn1provided by MGI
Official Full Name: centrin 1provided by MGI
Primary source: MGI:MGI:1347086
See related: Ensembl:ENSMUSG00000050996 AllianceGenome:MGI:1347086
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: caltractin
Summary: Enables G-protein beta/gamma-subunit complex binding activity; heterotrimeric G-protein binding activity; and microtubule binding activity. Acts upstream of or within cellular response to heat. Located in centrosome and photoreceptor connecting cilium. Is expressed in embryo; inner cell mass; and photoreceptor layer. Orthologous to human CETN1 (centrin 1). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: human all
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Genomic context

Location:: 18 A1; 18 4.91 cM

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	18	NC_000084.7 (9618419..9619469, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	18	NC_000084.6 (9618419..9619469, complement)

Chromosome 18 - NC_000084.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The crystal structure exhibits three structural features, i.e. four Ca2+ equally occupied at each EF-hand motif, structural changes accompanying helix motion at the N- and C-lobes, and adoption of N-C type dimerization when Ca2+ binds to EF-hand I and II in the N-lobe.
Title: Crystal Structure of Wild-Type Centrin 1 from Mus musculus Occupied by Ca2.
Experiments utilizing mouse embryo fibroblasts (MEFs) demonstrated the feasibility of real-time imaging, and showed that EGFP-Centrin1 expression mirrored the endogenous centrosome cycle, undergoing precisely one round of duplication through the cell cycle. Moreover, experiments using embryo and adult mouse tissues demonstrated that EGFP-Centrin1 specifically mirrors the localization of endogenous centrosomes.
Title: Generation and Characterization of a Tissue-Specific Centrosome Indicator Mouse Line.
role in late steps of spermiogenesis and spermatid maturation
Title: Germline deletion of Cetn1 causes infertility in male mice.
Immunostaining of seminiferous tubules revealed that cells in layer containing spermatogonia showed colocalization of SUMO-2/3 with centrin-1 in cytoplasmic spots. Binding of centrin-1 and SUMO-2/3 appears to be calcium dependent.
Title: An EF-hands protein, centrin-1, is an EGTA-sensitive SUMO-interacting protein in mouse testis.
Cen1 and Cen2 contribute to the centrin-transducin complex and potentially participate in the regulation of transducin translocation through the photoreceptor cilium
Title: Differential expression and interaction with the visual G-protein transducin of centrin isoforms in mammalian photoreceptor cells.
Calcium-dependent assembly of centrin-G-protein complex in photoreceptor cells
Title: Calcium-dependent assembly of centrin-G-protein complex in photoreceptor cells.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2) 1 citation
Targeted (2) 1 citation

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables G-protein beta/gamma-subunit complex binding	IDA Inferred from Direct Assay more info	PubMed
enables calcium ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables heterotrimeric G-protein binding	IDA Inferred from Direct Assay more info	PubMed
enables microtubule binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in cell division	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cellular response to heat	IDA Inferred from Direct Assay more info	PubMed
involved_in centriole replication	IBA Inferred from Biological aspect of Ancestor more info
involved_in microtubule cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in centriole	IBA Inferred from Biological aspect of Ancestor more info
located_in centriole	ISO Inferred from Sequence Orthology more info	PubMed
is_active_in centrosome	IBA Inferred from Biological aspect of Ancestor more info
located_in centrosome	IDA Inferred from Direct Assay more info	PubMed
located_in centrosome	ISO Inferred from Sequence Orthology more info	PubMed
located_in cilium	TAS Traceable Author Statement more info
located_in cytosol	TAS Traceable Author Statement more info
located_in microtubule organizing center	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in photoreceptor connecting cilium	IDA Inferred from Direct Assay more info	PubMed
located_in spindle pole	IEA Inferred from Electronic Annotation more info
located_in spindle pole	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: centrin-1

Names: testis-specific murine centrin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.