Taf4 TATA-box binding protein associated factor 4 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Taf4provided by MGI
Official Full Name: TATA-box binding protein associated factor 4provided by MGI
Primary source: MGI:MGI:2152346
See related: Ensembl:ENSMUSG00000039117 AllianceGenome:MGI:2152346
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Taf4a; 135kDa; Taf2c1; TAFII130; TAFII135
Summary: Enables DNA binding activity. Acts upstream of or within DNA-templated transcription and ovarian follicle development. Located in male germ cell nucleus. Is expressed in brain; spinal cord; tail; and thymus. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder. Orthologous to human TAF4 (TATA-box binding protein associated factor 4). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in thymus adult (RPKM 9.9), colon adult (RPKM 7.4) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 H4; 2 102.42 cM

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (179553945..179618519, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (179912146..179976646, complement)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Single cell transcriptomics reveal trans-differentiation of pancreatic beta cells following inactivation of the TFIID subunit Taf4.
Title: Single cell transcriptomics reveal trans-differentiation of pancreatic beta cells following inactivation of the TFIID subunit Taf4.
Ectopic expression of the TAF4 histone-fold fragment can efficiently squelch TAF12 in cells
Title: A TFIID-SAGA Perturbation that Targets MYB and Suppresses Acute Myeloid Leukemia.
Local promoter-proximal HNF4A-TFIID interactions therefore act as instructive signals for post-natal hepatocyte differentiation.
Title: TAF4, a subunit of transcription factor II D, directs promoter occupancy of nuclear receptor HNF4A during post-natal hepatocyte differentiation.
Data show that the TFIID subunit TAF4 is essential to restrain the growth promoting properties of collagen 6A3 (Col6a3).
Title: TAF4 inactivation reveals the 3 dimensional growth promoting activities of collagen 6A3.
A role for TAF4 as a cofactor in the cellular response to trans retinoic acid.
Title: Retinoic acid induces TGFbeta-dependent autocrine fibroblast growth.
TAF4 is an important regulator of keratinocyte proliferation and has cell-autonomous and non-cell-autonomous tumour suppressor activity.
Title: The TFIID subunit TAF4 regulates keratinocyte proliferation and has cell-autonomous and non-cell-autonomous tumour suppressor activity in mouse epidermis.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AI450312 (e-PCR)
- UniSTS:165235

UniSTS:234624 (e-PCR)
- UniSTS:234624

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables DNA binding	IDA Inferred from Direct Assay more info	PubMed
contributes_to RNA polymerase II general transcription initiation factor activity	IBA Inferred from Biological aspect of Ancestor more info
contributes_to RNA polymerase II general transcription initiation factor activity	ISO Inferred from Sequence Orthology more info
enables aryl hydrocarbon receptor binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within DNA-templated transcription	TAS Traceable Author Statement more info	PubMed
involved_in DNA-templated transcription initiation	ISO Inferred from Sequence Orthology more info
involved_in RNA polymerase II preinitiation complex assembly	ISO Inferred from Sequence Orthology more info
involved_in mRNA transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within ovarian follicle development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription initiation by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within transcription by RNA polymerase II	TAS Traceable Author Statement more info	PubMed
involved_in transcription initiation at RNA polymerase II promoter	IBA Inferred from Biological aspect of Ancestor more info
involved_in transcription initiation at RNA polymerase II promoter	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of MLL1 complex	ISO Inferred from Sequence Orthology more info
located_in chromatin	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in male germ cell nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info
part_of transcription factor TFIID complex	IBA Inferred from Biological aspect of Ancestor more info
part_of transcription factor TFIID complex	ISO Inferred from Sequence Orthology more info	PubMed
part_of transcription factor TFTC complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: transcription initiation factor TFIID subunit 4

Names: TAF4A RNA polymerase II, TATA box binding protein (TBP)-associated factor; TATA box binding protein (TBP)-associated factor, RNA polymerase II, C1, 130kd

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001081092.2 → NP_001074561.1 transcription initiation factor TFIID subunit 4

Status: VALIDATED

Source sequence(s)

AL663067

Consensus CDS

CCDS38373.1

UniProtKB/TrEMBL

E9QAP7

Related

ENSMUSP00000038610.8, ENSMUST00000041618.13

Conserved Domains (2) summary

pfam05236
Location:791 → 1039

TAF4; Transcription initiation factor TFIID component TAF4 family

pfam07531
Location:550 → 633

TAFH; NHR1 homology to TAF

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000068.8 Reference GRCm39 C57BL/6J

Range

179553945..179618519 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006500588.2 → XP_006500651.2 transcription initiation factor TFIID subunit 4 isoform X1

UniProtKB/TrEMBL

A0A2I3BPN6

Related

ENSMUSP00000153863.2, ENSMUST00000227325.2

Conserved Domains (2) summary

pfam05236
Location:779 → 1027

TAF4; Transcription initiation factor TFIID component TAF4 family

pfam07531
Location:550 → 633

TAFH; NHR1 homology to TAF