U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Me2 malic enzyme 2, NAD(+)-dependent, mitochondrial [ Mus musculus (house mouse) ]

    Gene ID: 107029, updated on 9-Dec-2024

    Summary

    Official Symbol
    Me2provided by MGI
    Official Full Name
    malic enzyme 2, NAD(+)-dependent, mitochondrialprovided by MGI
    Primary source
    MGI:MGI:2147351
    See related
    Ensembl:ENSMUSG00000024556 AllianceGenome:MGI:2147351
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    NAD-ME; D030040L20Rik
    Summary
    Enables malate dehydrogenase (decarboxylating) (NAD+) activity. Involved in pyruvate metabolic process. Located in mitochondrion. Is active in mitochondrial matrix. Is expressed in several structures, including central nervous system; integumental system; metanephros; sensory organ; and skeleton. Orthologous to human ME2 (malic enzyme 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in large intestine adult (RPKM 31.9), duodenum adult (RPKM 13.7) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Me2 in Genome Data Viewer
    Location:
    18 E2; 18 49.95 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (73898025..73949326, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (73764954..73815438, complement)

    Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene EGF-like domain 7 pseudogene Neighboring gene elaC ribonuclease Z 1 Neighboring gene STARR-positive B cell enhancer ABC_E11003 Neighboring gene STARR-seq mESC enhancer starr_44997 Neighboring gene predicted gene, 52346 Neighboring gene predicted gene, 32661 Neighboring gene maestro

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Chemically induced (ENU) (1) 
    • Endonuclease-mediated (1) 
    • Gene trapped (1) 
    • Targeted (2) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables NAD binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables malate dehydrogenase (decarboxylating) (NAD+) activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables malate dehydrogenase (decarboxylating) (NADP+) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables malic enzyme activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables oxaloacetate decarboxylase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in malate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in pyruvate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in pyruvate metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of NADP metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of NADP metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in mitochondrial matrix IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    NAD-dependent malic enzyme, mitochondrial
    NP_663469.1
    XP_006525559.1
    XP_036016815.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_145494.3NP_663469.1  NAD-dependent malic enzyme, mitochondrial precursor

      See identical proteins and their annotated locations for NP_663469.1

      Status: VALIDATED

      Source sequence(s)
      AC132418
      Consensus CDS
      CCDS29339.1
      UniProtKB/Swiss-Prot
      Q3TBM8, Q99KE1
      UniProtKB/TrEMBL
      Q3TSD4
      Related
      ENSMUSP00000025439.4, ENSMUST00000025439.5
      Conserved Domains (3) summary
      cd05312
      Location:280558
      NAD_bind_1_malic_enz; NAD(P) binding domain of malic enzyme (ME), subgroup 1
      PLN03129
      Location:28566
      PLN03129; NADP-dependent malic enzyme; Provisional
      pfam00390
      Location:89270
      malic; Malic enzyme, N-terminal domain

    RNA

    1. NR_157387.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC132418, AK077746

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000084.7 Reference GRCm39 C57BL/6J

      Range
      73898025..73949326 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036160922.1XP_036016815.1  NAD-dependent malic enzyme, mitochondrial isoform X2

      Conserved Domains (1) summary
      PLN03129
      Location:1390
      PLN03129; NADP-dependent malic enzyme; Provisional
    2. XM_006525496.4XP_006525559.1  NAD-dependent malic enzyme, mitochondrial isoform X1

      UniProtKB/TrEMBL
      Q3TSD4
      Conserved Domains (1) summary
      PLN03129
      Location:35573
      PLN03129; NADP-dependent malic enzyme; Provisional