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    Nfib nuclear factor I/B [ Mus musculus (house mouse) ]

    Gene ID: 18028, updated on 3-Dec-2024

    Summary

    Official Symbol
    Nfibprovided by MGI
    Official Full Name
    nuclear factor I/Bprovided by MGI
    Primary source
    MGI:MGI:103188
    See related
    Ensembl:ENSMUSG00000008575 AllianceGenome:MGI:103188
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CTF; NF1-B; NFI-B; NF-I/B; 6720429L07Rik; E030026I10Rik
    Summary
    Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including lung epithelial cell differentiation; negative regulation of cell population proliferation; and nervous system development. Acts upstream of or within several processes, including exit from mitosis; nervous system development; and salivary gland development. Located in cerebellar mossy fiber and nucleus. Is expressed in several structures, including alimentary system; genitourinary system; limb; nervous system; and respiratory system. Orthologous to human NFIB (nuclear factor I B). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in CNS E14 (RPKM 21.2), whole brain E14.5 (RPKM 17.6) and 21 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Nfib in Genome Data Viewer
    Location:
    4 C3; 4 38.4 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (82208410..82424988, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (82290173..82506751, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 46886 Neighboring gene predicted gene 11264 Neighboring gene predicted gene 5860 Neighboring gene STARR-seq mESC enhancer starr_10611 Neighboring gene STARR-seq mESC enhancer starr_10617 Neighboring gene STARR-seq mESC enhancer starr_10620 Neighboring gene RIKEN cDNA 2310067E19 gene Neighboring gene STARR-seq mESC enhancer starr_10622 Neighboring gene STARR-seq mESC enhancer starr_10623 Neighboring gene STARR-seq mESC enhancer starr_10624 Neighboring gene predicted gene 11266 Neighboring gene predicted gene 11267

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables DNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables DNA-binding transcription activator activity, RNA polymerase II-specific IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
     
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables DNA-binding transcription factor activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
     
    enables DNA-binding transcription factor activity, RNA polymerase II-specific ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables sequence-specific double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in DNA replication IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in anterior commissure morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in brain development ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within cell differentiation involved in salivary gland development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of cell population proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cell proliferation in forebrain IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within cell quiescence IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in chondrocyte differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in club cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in commissural neuron axon guidance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within exit from mitosis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within forebrain development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in gene expression IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within generation of neurons IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within glandular epithelial cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in glial cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within glial cell fate specification IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within glial cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within hindbrain development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in lung ciliated cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within lung development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of epithelial cell proliferation involved in lung morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of mesenchymal cell proliferation involved in lung development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of miRNA transcription IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of miRNA transcription ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within negative regulation of stem cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within neural precursor cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within neurogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within neuron fate specification IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in principal sensory nucleus of trigeminal nerve development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regeneration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within response to bacterium IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    acts_upstream_of_or_within response to wounding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within retina development in camera-type eye IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within salivary gland cavitation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within stem cell population maintenance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of stem cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within tissue homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in type I pneumocyte differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in type II pneumocyte differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cerebellar mossy fiber IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in fibrillar center IEA
    Inferred from Electronic Annotation
    more info
     
    located_in fibrillar center ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    nuclear factor 1 B-type
    Names
    CCAAT-box-binding transcription factor
    TGGCA-binding protein
    nuclear factor 1/B

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001113209.3NP_001106680.1  nuclear factor 1 B-type isoform 1

      See identical proteins and their annotated locations for NP_001106680.1

      Status: VALIDATED

      Source sequence(s)
      AL592283, AL773518, BX324149
      Consensus CDS
      CCDS51213.1
      UniProtKB/Swiss-Prot
      P70252, P70253, P70254, P97863, Q9R1G4
      UniProtKB/TrEMBL
      A2BG77
      Related
      ENSMUSP00000052863.9, ENSMUST00000050872.15
      Conserved Domains (3) summary
      pfam00859
      Location:209498
      CTF_NFI; CTF/NF-I family transcription modulation region
      pfam10524
      Location:1047
      NfI_DNAbd_pre-N; Nuclear factor I protein pre-N-terminus
      cl00055
      Location:69173
      MH1; N-terminal Mad Homology 1 (MH1) domain
    2. NM_001113210.3NP_001106681.1  nuclear factor 1 B-type isoform 2

      See identical proteins and their annotated locations for NP_001106681.1

      Status: VALIDATED

      Source sequence(s)
      AL592283, AL773518, BX324149
      UniProtKB/TrEMBL
      A2BG75
      Related
      ENSMUSP00000102868.2, ENSMUST00000107247.8
      Conserved Domains (3) summary
      pfam00859
      Location:209489
      CTF_NFI; CTF/NF-I family transcription modulation region
      pfam10524
      Location:1047
      NfI_DNAbd_pre-N; Nuclear factor I protein pre-N-terminus
      cl00055
      Location:69173
      MH1; N-terminal Mad Homology 1 (MH1) domain
    3. NM_001286127.2NP_001273056.1  nuclear factor 1 B-type isoform 4

      Status: VALIDATED

      Source sequence(s)
      AL592283, AL773518, BX324149
      UniProtKB/TrEMBL
      I7HIP8
      Related
      ENSMUSP00000102865.3, ENSMUST00000107245.9
      Conserved Domains (3) summary
      pfam00859
      Location:209493
      CTF_NFI; CTF/NF-I family transcription modulation region
      pfam10524
      Location:1047
      NfI_DNAbd_pre-N; Nuclear factor I protein pre-N-terminus
      cl00055
      Location:69173
      MH1; N-terminal Mad Homology 1 (MH1) domain
    4. NM_001286131.2NP_001273060.1  nuclear factor 1 B-type isoform 5

      See identical proteins and their annotated locations for NP_001273060.1

      Status: VALIDATED

      Source sequence(s)
      AL592283, AL773518, BX324149
      UniProtKB/TrEMBL
      A2BG76
      Related
      ENSMUSP00000102866.2, ENSMUST00000107246.2
      Conserved Domains (3) summary
      cl00055
      Location:69173
      MH1; N-terminal Mad Homology 1 (MH1) domain
      pfam00859
      Location:209416
      CTF_NFI; CTF/NF-I family transcription modulation region
      pfam10524
      Location:947
      NfI_DNAbd_pre-N; Nuclear factor I protein pre-N-terminus
    5. NM_001429559.1NP_001416488.1  nuclear factor 1 B-type isoform 6

      Status: VALIDATED

      Source sequence(s)
      AL592283, AL773518, BX324149
      UniProtKB/TrEMBL
      A2BG77
    6. NM_001429560.1NP_001416489.1  nuclear factor 1 B-type isoform 7

      Status: VALIDATED

      Source sequence(s)
      AL592283, AL670769, AL773518, BX324149
      UniProtKB/TrEMBL
      I7HIP8
    7. NM_001429561.1NP_001416490.1  nuclear factor 1 B-type isoform 8

      Status: VALIDATED

      Source sequence(s)
      AL592283, AL773518, BX324149
      UniProtKB/TrEMBL
      I7HIP8
    8. NM_001429562.1NP_001416491.1  nuclear factor 1 B-type isoform 9

      Status: VALIDATED

      Source sequence(s)
      AL592283, AL773518, BX324149
      UniProtKB/TrEMBL
      A2BG76
    9. NM_001429563.1NP_001416492.1  nuclear factor 1 B-type isoform 10

      Status: VALIDATED

      Source sequence(s)
      AL592283, AL670769, AL773518, BX324149
      UniProtKB/TrEMBL
      Q8C434
    10. NM_001429564.1NP_001416493.1  nuclear factor 1 B-type isoform 11

      Status: VALIDATED

      Source sequence(s)
      AL592283, AL773518, BX324149
      UniProtKB/TrEMBL
      Q8C434
    11. NM_008687.7NP_032713.3  nuclear factor 1 B-type isoform 3

      See identical proteins and their annotated locations for NP_032713.3

      Status: VALIDATED

      Source sequence(s)
      AL592283, AL773518, BX324149
      Consensus CDS
      CCDS38790.1
      UniProtKB/TrEMBL
      Q6GSP7, Q8C434
      Related
      ENSMUSP00000067629.3, ENSMUST00000064770.9
      Conserved Domains (3) summary
      pfam00859
      Location:209415
      CTF_NFI; CTF/NF-I family transcription modulation region
      pfam10524
      Location:1047
      NfI_DNAbd_pre-N; Nuclear factor I protein pre-N-terminus
      cl00055
      Location:69173
      MH1; N-terminal Mad Homology 1 (MH1) domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      82208410..82424988 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017320022.3XP_017175511.1  nuclear factor 1 B-type isoform X5

      UniProtKB/TrEMBL
      Q8C434
      Conserved Domains (3) summary
      pfam00859
      Location:209416
      CTF_NFI; CTF/NF-I family transcription modulation region
      pfam10524
      Location:1047
      NfI_DNAbd_pre-N; Nuclear factor I protein pre-N-terminus
      cl00055
      Location:69173
      MH1; N-terminal Mad Homology 1 (MH1) domain
    2. XM_006537654.3XP_006537717.1  nuclear factor 1 B-type isoform X2

      Conserved Domains (3) summary
      pfam00859
      Location:209502
      CTF_NFI; CTF/NF-I family transcription modulation region
      pfam10524
      Location:1047
      NfI_DNAbd_pre-N; Nuclear factor I protein pre-N-terminus
      cl00055
      Location:69173
      MH1; N-terminal Mad Homology 1 (MH1) domain
    3. XM_036163813.1XP_036019706.1  nuclear factor 1 B-type isoform X6

      Conserved Domains (3) summary
      pfam10524
      Location:238
      NfI_DNAbd_pre-N; Nuclear factor I protein pre-N-terminus
      pfam00859
      Location:200406
      CTF_NFI; CTF/NF-I family transcription modulation region
      cl00055
      Location:60164
      MH1; N-terminal Mad Homology 1 (MH1) domain
    4. XM_030253304.2XP_030109164.1  nuclear factor 1 B-type isoform X4

      Conserved Domains (4) summary
      PRK15127
      Location:376466
      PRK15127; multidrug efflux RND transporter permease subunit AcrB
      pfam00859
      Location:200407
      CTF_NFI; CTF/NF-I family transcription modulation region
      pfam10524
      Location:238
      NfI_DNAbd_pre-N; Nuclear factor I protein pre-N-terminus
      cl00055
      Location:60164
      MH1; N-terminal Mad Homology 1 (MH1) domain
    5. XM_036163812.1XP_036019705.1  nuclear factor 1 B-type isoform X3

      UniProtKB/TrEMBL
      I7HIP8
      Conserved Domains (3) summary
      pfam10524
      Location:238
      NfI_DNAbd_pre-N; Nuclear factor I protein pre-N-terminus
      pfam00859
      Location:200493
      CTF_NFI; CTF/NF-I family transcription modulation region
      cl00055
      Location:60164
      MH1; N-terminal Mad Homology 1 (MH1) domain
    6. XM_006537653.5XP_006537716.1  nuclear factor 1 B-type isoform X1

      Conserved Domains (3) summary
      pfam00859
      Location:200489
      CTF_NFI; CTF/NF-I family transcription modulation region
      pfam10524
      Location:238
      NfI_DNAbd_pre-N; Nuclear factor I protein pre-N-terminus
      cl00055
      Location:60164
      MH1; N-terminal Mad Homology 1 (MH1) domain

    RNA

    1. XR_004941830.1 RNA Sequence