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    Ankrd7 ankyrin repeat domain 7 [ Mus musculus (house mouse) ]

    Gene ID: 75196, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ankrd7provided by MGI
    Official Full Name
    ankyrin repeat domain 7provided by MGI
    Primary source
    MGI:MGI:1922446
    See related
    Ensembl:ENSMUSG00000029517 AllianceGenome:MGI:1922446
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    4930532L20Rik
    Summary
    Acts upstream of or within blastocyst hatching. Located in nucleus. Is expressed in early conceptus. Orthologous to human ANKRD7 (ankyrin repeat domain 7). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in testis adult (RPKM 1.7), cerebellum adult (RPKM 0.3) and 10 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ankrd7 in Genome Data Viewer
    Location:
    6 A2; 6 8.16 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (18855830..18879588)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (18855842..18879589)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer mm9_chr6:18798382-18798683 Neighboring gene STARR-seq mESC enhancer starr_15273 Neighboring gene predicted gene 5874 Neighboring gene LSM8 homolog, U6 small nuclear RNA associated Neighboring gene STARR-seq mESC enhancer starr_15274 Neighboring gene STARR-seq mESC enhancer starr_15275 Neighboring gene STARR-seq mESC enhancer starr_15276 Neighboring gene protein disulfide isomerase associated 6 pseudogene Neighboring gene STARR-seq mESC enhancer starr_15277 Neighboring gene RIKEN cDNA 4930524B17 gene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Ankrd7, a novel gene specifically expressed in Sertoli cells and its potential roles in Sertoli cell maturation. Shi YQ, et al. Mol Cells, 2009 Feb 28. PMID 19277502
    2. CRISPR/Cas9-mediated genome editing reveals 30 testis-enriched genes dispensable for male fertility in mice†. Lu Y, et al. Biol Reprod, 2019 Aug 1. PMID 31201419, Free PMC Article
    3. Towards Functional Annotation of the Preimplantation Transcriptome: An RNAi Screen in Mammalian Embryos. Cui W, et al. Sci Rep, 2016 Nov 21. PMID 27869233, Free PMC Article
    4. An atlas of combinatorial transcriptional regulation in mouse and man. Ravasi T, et al. Cell, 2010 Mar 5. PMID 20211142, Free PMC Article
    5. A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Yokoyama S, et al. Dev Cell, 2009 Dec. PMID 20059953, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1)  1 citation
    • Targeted (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within blastocyst hatching IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    ankyrin repeat domain-containing protein 7

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001167757.1 → NP_001161229.1  ankyrin repeat domain-containing protein 7 isoform 1

      See identical proteins and their annotated locations for NP_001161229.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC167438, AK077080, BB019296
      Consensus CDS
      CCDS51724.1
      UniProtKB/TrEMBL
      A0A0R4J1L1
      Related
      ENSMUSP00000111054.3, ENSMUST00000115396.7
      Conserved Domains (4) summary
      cd00204
      Location:75 → 201
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:121 → 211
      Ank_2; Ankyrin repeats (3 copies)
      pfam13857
      Location:200 → 254
      Ank_5; Ankyrin repeats (many copies)
      sd00045
      Location:113 → 145
      ANK; ANK repeat [structural motif]

    2. NM_029202.2 → NP_083478.2  ankyrin repeat domain-containing protein 7 isoform 2

      See identical proteins and their annotated locations for NP_083478.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice junction at the 5' end of an exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is one aa shorter compared to isoform 1.
      Source sequence(s)
      AC167438, AK015948, AK077080, BB019296
      Consensus CDS
      CCDS19933.1
      UniProtKB/Swiss-Prot
      Q810N2, Q8BVP4, Q9D504
      Related
      ENSMUSP00000031489.7, ENSMUST00000031489.10
      Conserved Domains (4) summary
      cd00204
      Location:75 → 200
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:118 → 210
      Ank_2; Ankyrin repeats (3 copies)
      pfam13857
      Location:199 → 253
      Ank_5; Ankyrin repeats (many copies)
      sd00045
      Location:113 → 144
      ANK; ANK repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      18855830..18879588
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006505191.5 → XP_006505254.1  ankyrin repeat domain-containing protein 7 isoform X1

      Conserved Domains (2) summary
      sd00045
      Location:56 → 88
      ANK; ANK repeat [structural motif]
      cl39094
      Location:25 → 178
      Ank_2; Ankyrin repeats (3 copies)

    2. XM_006505192.3 → XP_006505255.1  ankyrin repeat domain-containing protein 7 isoform X2

      Conserved Domains (2) summary
      sd00045
      Location:113 → 145
      ANK; ANK repeat [structural motif]
      cl39094
      Location:51 → 213
      Ank_2; Ankyrin repeats (3 copies)

    RNA

    1. XR_003956259.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9D504.2 GenPept UniProtKB/Swiss-Prot:Q9D504

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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