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    Ferd3l Fer3 like bHLH transcription factor [ Mus musculus (house mouse) ]

    Gene ID: 114712, updated on 27-Nov-2024

    Summary

    Official Symbol
    Ferd3lprovided by MGI
    Official Full Name
    Fer3 like bHLH transcription factorprovided by MGI
    Primary source
    MGI:MGI:2150010
    See related
    Ensembl:ENSMUSG00000046518 AllianceGenome:MGI:2150010
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Nato; Ptfb; fer3; Nato3; Mnato3; Ntwist; N-twist; bHLHa31
    Summary
    Enables DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in negative regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including floor plate development; regulation of dopaminergic neuron differentiation; and regulation of neurogenesis. Located in nucleus. Is expressed in several structures, including central nervous system; eye; future midbrain; genitourinary system; and liver. Orthologous to human FERD3L (Fer3 like bHLH transcription factor). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
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    Genomic context

    See Ferd3l in Genome Data Viewer
    Location:
    12 A3; 12 14.79 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (33978424..33979309)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (33928425..33929310)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene ribosomal protein SA pseudogene Neighboring gene STARR-seq mESC enhancer starr_31897 Neighboring gene high mobility group box 1-like pseudogene Neighboring gene STARR-seq mESC enhancer starr_31899 Neighboring gene predicted gene, 40383 Neighboring gene STARR-seq mESC enhancer starr_31900 Neighboring gene twist basic helix-loop-helix transcription factor 1 Neighboring gene histone deacetylase 9 Neighboring gene predicted gene, 40384

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC130442

    Gene Ontology Provided by MGI

    Component Evidence Code Pubs
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    fer3-like protein
    Names
    Fer3-like
    basic helix-loop-helix protein N-twist
    nephew of atonal 3
    neuronal twist
    pancreas-specific transcription factor b

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_033522.2NP_277057.1  fer3-like protein

      See identical proteins and their annotated locations for NP_277057.1

      Status: PROVISIONAL

      Source sequence(s)
      AF517121
      Consensus CDS
      CCDS25878.1
      UniProtKB/Swiss-Prot
      Q923Z4
      Related
      ENSMUSP00000058994.4, ENSMUST00000061035.4
      Conserved Domains (1) summary
      pfam00010
      Location:104156
      HLH; Helix-loop-helix DNA-binding domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      33978424..33979309
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)