U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Tnpo1 transportin 1 [ Mus musculus (house mouse) ]

    Gene ID: 238799, updated on 3-Dec-2024

    Summary

    Official Symbol
    Tnpo1provided by MGI
    Official Full Name
    transportin 1provided by MGI
    Primary source
    MGI:MGI:2681523
    See related
    Ensembl:ENSMUSG00000009470 AllianceGenome:MGI:2681523
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    MIP; TRN; IPO2; MIP1; Kpnb2; D13Ertd688e
    Summary
    Predicted to enable nuclear import signal receptor activity and nuclear localization sequence binding activity. Predicted to be involved in protein import into nucleus. Predicted to be active in cytoplasm and nucleus. Orthologous to human TNPO1 (transportin 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 23.2), whole brain E14.5 (RPKM 19.8) and 28 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Tnpo1 in Genome Data Viewer
    Location:
    13 D1; 13 52.24 cM
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (98975527..99062851, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (98839019..98926384, complement)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene FCH domain only 2 Neighboring gene predicted gene, 34995 Neighboring gene ribosomal protein S17 pseudogene Neighboring gene CapStarr-seq enhancer MGSCv37_chr13:99660904-99661128 Neighboring gene ribosomal protein L27A, pseudogene 4 Neighboring gene predicted gene, 52051 Neighboring gene predicted gene, 35215 Neighboring gene predicted gene, 47052

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables nuclear import signal receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables nuclear localization sequence binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables small GTPase binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in protein import into nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in protein import into nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein import into nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    transportin-1
    Names
    importin beta-2
    karyopherin (importin) beta 2
    karyopherin beta-2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001048267.2NP_001041732.1  transportin-1 isoform 2

      See identical proteins and their annotated locations for NP_001041732.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains a distinct 5' UTR and uses a downstream start codon, compared to variant 1. Isoform 2 has a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AC129085, AC154849
      Consensus CDS
      CCDS36760.1
      UniProtKB/TrEMBL
      Q3TKD0
      Related
      ENSMUSP00000105026.3, ENSMUST00000109399.9
      Conserved Domains (2) summary
      COG5215
      Location:24759
      KAP95; Karyopherin (importin) beta [Intracellular trafficking and secretion]
      sd00044
      Location:95116
      HEAT; HEAT repeat [structural motif]
    2. NM_001426412.1NP_001413341.1  transportin-1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC129085, AC154849
      UniProtKB/TrEMBL
      Q3TKD0
    3. NM_001426413.1NP_001413342.1  transportin-1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC129085, AC154849
      UniProtKB/TrEMBL
      Q3TKD0
    4. NM_001426414.1NP_001413343.1  transportin-1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC129085, AC154849
      UniProtKB/TrEMBL
      Q3TKD0
      Related
      ENSMUSP00000136917.2, ENSMUST00000179301.8
    5. NM_001426415.1NP_001413344.1  transportin-1 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC129085, AC154849
    6. NM_178716.4NP_848831.2  transportin-1 isoform 1

      See identical proteins and their annotated locations for NP_848831.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer protein (isoform 1).
      Source sequence(s)
      AC129085, AC154849
      Consensus CDS
      CCDS26717.2
      UniProtKB/Swiss-Prot
      Q8BFY9, Q8C0S3, Q8K2E7
      UniProtKB/TrEMBL
      Q3TKD0
      Related
      ENSMUSP00000105028.2, ENSMUST00000109401.8
      Conserved Domains (2) summary
      COG5215
      Location:32767
      KAP95; Karyopherin (importin) beta [Intracellular trafficking and secretion]
      sd00044
      Location:103124
      HEAT; HEAT repeat [structural motif]

    RNA

    1. NR_189735.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC129085, AC154849

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      98975527..99062851 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)