Hoxb5 homeobox B5 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Hoxb5provided by MGI
Official Full Name: homeobox B5provided by MGI
Primary source: MGI:MGI:96186
See related: Ensembl:ENSMUSG00000038700 AllianceGenome:MGI:96186
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Hox-2.1
Summary: Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in positive regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including embryonic skeletal system morphogenesis; endothelial cell differentiation; and regulation of DNA-templated transcription. Located in nucleus. Is expressed in several structures, including embryo mesenchyme; genitourinary system; gut; lung; and nervous system. Orthologous to human HOXB5 (homeobox B5). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Broad expression in adrenal adult (RPKM 20.9), CNS E14 (RPKM 8.8) and 15 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 D; 11 59.82 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (96194338..96196947)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (96303512..96306121)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Transcription factor Hoxb5 reveals the unidirectional hierarchy of hematopoietic stem cell pool.
Title: Transcription factor Hoxb5 reveals the unidirectional hierarchy of hematopoietic stem cell pool.
Hoxb5 reprogrammes murine multipotent blood progenitors into haematopoietic stem cell-like cells.
Title: Hoxb5 reprogrammes murine multipotent blood progenitors into haematopoietic stem cell-like cells.
Homeobox B5 promotes metastasis and poor prognosis in Hepatocellular Carcinoma, via FGFR4 and CXCL1 upregulation.
Title: Homeobox B5 promotes metastasis and poor prognosis in Hepatocellular Carcinoma, via FGFR4 and CXCL1 upregulation.
The ciliary Frizzled-like receptor Tmem67 regulates canonical Wnt/beta-catenin signalling in the developing cerebellum via Hoxb5.
Title: The ciliary Frizzled-like receptor Tmem67 regulates canonical Wnt/β-catenin signalling in the developing cerebellum via Hoxb5.
Investigated role of neogenin (NEO1) and homeobox B5 (Hoxb5) in differentiation of a specific subpopulation of mouse hematopoietic stem cells.
Title: Neogenin-1 distinguishes between myeloid-biased and balanced Hoxb5(+) mouse long-term hematopoietic stem cells.
we found that the transcription factor Hoxb5, which is expressed in uncommitted hematopoietic progenitor cells but is not present in cells committed to the B cell or T cell lineage, was able to reprogram pro-pre-B cells into functional early T cell lineage progenitors
Title: Transcription factor Hoxb5 reprograms B cells into functional T lymphocytes.
only the Hoxb5(+) hematopoietic stem cells exhibit long-term reconstitution capacity after transplantation in primary transplant recipients and, notably, in secondary recipients
Title: Hoxb5 marks long-term haematopoietic stem cells and reveals a homogenous perivascular niche.
Data indicate that homeobox b5 (Hoxb5) regulated the neural crest (NC)development by directly inducing Forkhead box D3 gene (Foxd3).
Title: Homeobox b5 (Hoxb5) regulates the expression of Forkhead box D3 gene (Foxd3) in neural crest.
The dysregulation of Hoxb5 signaling and early depletion of Neural crest cells contribute to enteric nervous system defect and other neurocristopathies in Hirschsprung disease patients deserves further investigation.
Title: Perturbation of Hoxb5 signaling in vagal and trunk neural crest cells causes apoptosis and neurocristopathies in mice.
TGF beta inhibition enhanced airway branching, and Hoxb5 protein cellular localization was more diffuse.
Title: Regulatory interactions between androgens, Hoxb5, and TGF β signaling in murine lung development.

Submit: New GeneRIF Correction See all GeneRIFs (13)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2) 1 citation
Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Hoxb5 (e-PCR), detects polymorphism
- UniSTS:143382

NoName (e-PCR)
- UniSTS:484893

UniSTS:265259 (e-PCR)
- UniSTS:265259

Hoxb5 (e-PCR), detects polymorphism
- UniSTS:265259

Hoxb5 (e-PCR), detects polymorphism
- UniSTS:536652

AI385717 (e-PCR)
- UniSTS:180302

NoName (e-PCR)
- UniSTS:548176

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables sequence-specific double-stranded DNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in anterior/posterior pattern specification	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within anterior/posterior pattern specification	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within anterior/posterior pattern specification	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within embryonic skeletal system development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within embryonic skeletal system morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within embryonic skeletal system morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within endothelial cell differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in fibrillar center	IEA Inferred from Electronic Annotation more info
located_in fibrillar center	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: homeobox protein Hox-B5

Names: homeo box B5; homeobox protein H24.1; homeobox protein Hox-2.1; homeobox protein Mu-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.