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    Map1a microtubule-associated protein 1 A [ Mus musculus (house mouse) ]

    Gene ID: 17754, updated on 27-Nov-2024

    Summary

    Official Symbol
    Map1aprovided by MGI
    Official Full Name
    microtubule-associated protein 1 Aprovided by MGI
    Primary source
    MGI:MGI:1306776
    See related
    Ensembl:ENSMUSG00000027254 AllianceGenome:MGI:1306776
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Mtap1; moth1; Mtap-1; Mtap1a; 6330416M19Rik
    Summary
    Enables cytoskeletal anchor activity; cytoskeletal protein binding activity; and ionotropic glutamate receptor binding activity. Involved in several processes, including axo-dendritic protein transport; learning or memory; and regulation of protein localization. Acts upstream of or within photoreceptor cell maintenance and sensory perception of sound. Located in several cellular components, including axon initial segment; dendritic microtubule; and postsynaptic density. Is expressed in cerebral cortex marginal zone; cortical plate; cortical subplate; and spinal cord. Orthologous to human MAP1A (microtubule associated protein 1A). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in cortex adult (RPKM 53.8), frontal lobe adult (RPKM 50.0) and 5 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Map1a in Genome Data Viewer
    Location:
    2 E5; 2 60.37 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (121119608..121141313)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (121289590..121310832)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene leucine carboxyl methyltransferase 2 Neighboring gene adenosine deaminase-like Neighboring gene zinc finger SCAN domains 29 Neighboring gene tubulin, gamma complex component 4 Neighboring gene transformation related protein 53 binding protein 1 Neighboring gene STARR-seq mESC enhancer starr_05522 Neighboring gene STARR-seq mESC enhancer starr_05523 Neighboring gene STARR-positive B cell enhancer ABC_E2640 Neighboring gene STARR-seq mESC enhancer starr_05524 Neighboring gene STARR-positive B cell enhancer ABC_E5972 Neighboring gene STARR-seq mESC enhancer starr_05525 Neighboring gene diphosphoinositol pentakisphosphate kinase 1 Neighboring gene STARR-positive B cell enhancer ABC_E640 Neighboring gene predicted gene, 33947 Neighboring gene creatine kinase, mitochondrial 1, ubiquitous Neighboring gene stereocilin

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables actin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables actin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables actin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables collagen binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables cytoskeletal anchor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables ionotropic glutamate receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables microtubule binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables microtubule binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables tubulin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in anterograde axonal protein transport IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in associative learning IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in axonogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in dendrite development IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in memory IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in microtubule cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in microtubule cytoskeleton organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of microtubule depolymerization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of proteasomal ubiquitin-dependent protein catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of protein localization to microtubule IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in neuron cellular homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in neuron projection maintenance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within photoreceptor cell maintenance IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of protein localization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of protein localization to cell surface IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of microtubule depolymerization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of synaptic plasticity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in retrograde axonal protein transport IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within sensory perception of sound IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in voluntary musculoskeletal movement IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in axon ISO
    Inferred from Sequence Orthology
    more info
     
    located_in axon cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in axon initial segment IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in dendrite IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in dendrite IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in dendrite ISO
    Inferred from Sequence Orthology
    more info
     
    located_in dendritic branch ISO
    Inferred from Sequence Orthology
    more info
     
    located_in dendritic microtubule IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in dendritic shaft ISO
    Inferred from Sequence Orthology
    more info
     
    NOT located_in distal axon NAS
    Non-traceable Author Statement
    more info
    PubMed 
    is_active_in microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of microtubule associated complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of microtubule associated complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in neuron projection ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in neuronal cell body IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in neuronal cell body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in photoreceptor outer segment IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in postsynaptic density IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in primary dendrite ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in synapse IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    microtubule-associated protein 1A
    Names
    MAP-1A
    modifier of tubby hearing 1
    short MAP1A
    short microtubule-associated protein 1A

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001173506.1NP_001166977.1  microtubule-associated protein 1A isoform 2

      See identical proteins and their annotated locations for NP_001166977.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has an alternate 5' sequence, resulting in a downstream AUG start codon, as compared to variant 1. The resulting isoform (2) has a shorter N-terminus, as compared to isoform 1.
      Source sequence(s)
      AK147474, AK160546, AL845466, BQ175021, CJ116735
      Consensus CDS
      CCDS50685.1
      UniProtKB/Swiss-Prot
      A2ARN9, Q3TQM8, Q3TUV8, Q3UHB7, Q9QYR6, Q9QZH9, Q9QZI0, Q9QZI1
      Related
      ENSMUSP00000106269.2, ENSMUST00000110639.8
      Conserved Domains (1) summary
      cl23716
      Location:46149
      metallo-hydrolase-like_MBL-fold; mainly hydrolytic enzymes and related proteins which carry out various biological functions; MBL-fold metallohydrolase domain
    2. NM_032393.2NP_115769.1  microtubule-associated protein 1A isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) is the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AF182213, AK147474, AK160546, AL845466, BQ175021
      Consensus CDS
      CCDS38215.1
      UniProtKB/TrEMBL
      A2ARP8
      Related
      ENSMUSP00000092223.4, ENSMUST00000094639.10
      Conserved Domains (1) summary
      cl23716
      Location:284387
      metallo-hydrolase-like_MBL-fold; mainly hydrolytic enzymes and related proteins which carry out various biological functions; MBL-fold metallohydrolase domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      121119608..121141313
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006498872.5XP_006498935.1  microtubule-associated protein 1A isoform X1

      Conserved Domains (3) summary
      PTZ00121
      Location:15671890
      PTZ00121; MAEBL; Provisional
      PHA03247
      Location:24162863
      PHA03247; large tegument protein UL36; Provisional
      PHA03307
      Location:19862355
      PHA03307; transcriptional regulator ICP4; Provisional