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    Ndst1 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1 [ Mus musculus (house mouse) ]

    Gene ID: 15531, updated on 9-Dec-2024

    Summary

    Official Symbol
    Ndst1provided by MGI
    Official Full Name
    N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1provided by MGI
    Primary source
    MGI:MGI:104719
    See related
    Ensembl:ENSMUSG00000054008 AllianceGenome:MGI:104719
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Hsst; HSNST; N-HSST; NDST-1; HSNST 1; N-HSST 1; b2b2230Clo; 1200015G06Rik
    Summary
    Enables N-acetylglucosamine deacetylase activity; [heparan sulfate]-glucosamine N-sulfotransferase activity; and heparan sulfate N-deacetylase activity. Involved in heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process. Acts upstream of or within several processes, including circulatory system development; embryonic cranial skeleton morphogenesis; and positive regulation of signal transduction. Is active in Golgi apparatus. Is expressed in several structures, including alimentary system; future brain; integumental system; nervous system; and respiratory system. Used to study DiGeorge syndrome; congenital diaphragmatic hernia; and newborn respiratory distress syndrome. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder 46. Orthologous to human NDST1 (N-deacetylase and N-sulfotransferase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in lung adult (RPKM 78.1), adrenal adult (RPKM 46.2) and 25 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Ndst1 in Genome Data Viewer
    Location:
    18 E1; 18 34.38 cM
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (60817566..60907465, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (60684494..60749035, complement)

    Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene synaptopodin Neighboring gene STARR-seq mESC enhancer starr_44719 Neighboring gene RIKEN cDNA G630071F17 gene Neighboring gene VISTA enhancer mm1623 Neighboring gene STARR-positive B cell enhancer ABC_E7590 Neighboring gene STARR-seq mESC enhancer starr_44724 Neighboring gene STARR-positive B cell enhancer mm9_chr18:60904284-60904585 Neighboring gene CapStarr-seq enhancer MGSCv37_chr18:60935339-60935448 Neighboring gene ribosomal protein S14 Neighboring gene 40S ribosomal protein S16 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Chemically induced (ENU) (1) 
    • Endonuclease-mediated (3) 
    • Targeted (5)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    acts_upstream_of_or_within animal organ morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within aorta development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within cardiac septum development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within cell population proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within coronary vasculature development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within embryo development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within embryonic neurocranium morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within embryonic viscerocranium morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within fibroblast growth factor receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within forebrain development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within forebrain development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within glycosaminoglycan metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within heart development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in heparan sulfate proteoglycan biosynthetic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in heparan sulfate proteoglycan biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in heparan sulfate proteoglycan biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in heparin biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in inflammatory response IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within midbrain development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within polysaccharide biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of MAPK cascade IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of smoothened signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within protein deacetylation TAS
    Traceable Author Statement
    more info
    PubMed 
    acts_upstream_of_or_within protein sulfation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within protein sulfation TAS
    Traceable Author Statement
    more info
    PubMed 
    acts_upstream_of_or_within respiratory gaseous exchange by respiratory system IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in trans-Golgi network membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in trans-Golgi network membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1
    Names
    N-heparan sulfate sulfotransferase 1
    [Heparan sulfate]-glucosamine N-sulfotransferase 1
    NP_001335029.1
    NP_001335030.1
    NP_001335031.1
    NP_001335032.1
    NP_001335075.1
    NP_032332.2
    XP_006525731.1
    XP_006525736.1
    XP_030106200.1
    XP_030106201.1
    XP_030106202.1
    XP_036016884.1
    XP_036016885.1
    XP_036016886.1
    XP_036016887.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001348100.1NP_001335029.1  bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1-5 encode the same isoform (1).
      Source sequence(s)
      AC139759, AI844370, AK004787, AK035642, BC079561
      Consensus CDS
      CCDS37834.1
      UniProtKB/Swiss-Prot
      O70353, Q3TBX3, Q3TDS3, Q3UHN9, Q8BZE5, Q9R206
      Conserved Domains (2) summary
      pfam00685
      Location:605855
      Sulfotransfer_1; Sulfotransferase domain
      pfam12062
      Location:30515
      HSNSD; heparan sulfate-N-deacetylase
    2. NM_001348101.1NP_001335030.1  bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1-5 encode the same isoform (1).
      Source sequence(s)
      AC139759, AI844370, AK004787, AK035642, BC079561
      Consensus CDS
      CCDS37834.1
      UniProtKB/Swiss-Prot
      O70353, Q3TBX3, Q3TDS3, Q3UHN9, Q8BZE5, Q9R206
      Related
      ENSMUSP00000126623.2, ENSMUST00000169273.2
      Conserved Domains (2) summary
      pfam00685
      Location:605855
      Sulfotransfer_1; Sulfotransferase domain
      pfam12062
      Location:30515
      HSNSD; heparan sulfate-N-deacetylase
    3. NM_001348102.1NP_001335031.1  bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1-5 encode the same isoform (1).
      Source sequence(s)
      AC149216, AI844370, AK004787, AK035642, BC079561
      Consensus CDS
      CCDS37834.1
      UniProtKB/Swiss-Prot
      O70353, Q3TBX3, Q3TDS3, Q3UHN9, Q8BZE5, Q9R206
      Conserved Domains (2) summary
      pfam00685
      Location:605855
      Sulfotransfer_1; Sulfotransferase domain
      pfam12062
      Location:30515
      HSNSD; heparan sulfate-N-deacetylase
    4. NM_001348103.1NP_001335032.1  bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. Variants 1-5 encode the same isoform (1).
      Source sequence(s)
      AC149216, AI844370, AK004787, AK035642, BC079561
      Consensus CDS
      CCDS37834.1
      UniProtKB/Swiss-Prot
      O70353, Q3TBX3, Q3TDS3, Q3UHN9, Q8BZE5, Q9R206
      Conserved Domains (2) summary
      pfam00685
      Location:605855
      Sulfotransfer_1; Sulfotransferase domain
      pfam12062
      Location:30515
      HSNSD; heparan sulfate-N-deacetylase
    5. NM_001348146.1NP_001335075.1  bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) has multiple differences in the 3' coding region and differs in the 3' UTR, compared to variant 1. It encodes isoform 2, which has a shorter and distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AC149216, AK035642
      UniProtKB/Swiss-Prot
      Q3UHN9
      Conserved Domains (1) summary
      pfam12062
      Location:30481
      HSNSD; heparan sulfate-N-deacetylase
    6. NM_008306.5NP_032332.2  bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1 isoform 1

      See identical proteins and their annotated locations for NP_032332.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1-5 encode the same isoform (1).
      Source sequence(s)
      AI844370, AK004787, AK035642, BC079561
      Consensus CDS
      CCDS37834.1
      UniProtKB/Swiss-Prot
      O70353, Q3TBX3, Q3TDS3, Q3UHN9, Q8BZE5, Q9R206
      Related
      ENSMUSP00000158312.2, ENSMUST00000237783.2
      Conserved Domains (2) summary
      pfam00685
      Location:605855
      Sulfotransfer_1; Sulfotransferase domain
      pfam12062
      Location:30515
      HSNSD; heparan sulfate-N-deacetylase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000084.7 Reference GRCm39 C57BL/6J

      Range
      60817566..60907465 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036160991.1XP_036016884.1  bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1 isoform X1

      UniProtKB/Swiss-Prot
      O70353, Q3TBX3, Q3TDS3, Q3UHN9, Q8BZE5, Q9R206
      Conserved Domains (2) summary
      pfam00685
      Location:605855
      Sulfotransfer_1; Sulfotransferase domain
      pfam12062
      Location:30515
      HSNSD; heparan sulfate-N-deacetylase
    2. XM_030250341.1XP_030106201.1  bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1 isoform X1

      UniProtKB/Swiss-Prot
      O70353, Q3TBX3, Q3TDS3, Q3UHN9, Q8BZE5, Q9R206
      Conserved Domains (2) summary
      pfam00685
      Location:605855
      Sulfotransfer_1; Sulfotransferase domain
      pfam12062
      Location:30515
      HSNSD; heparan sulfate-N-deacetylase
    3. XM_036160993.1XP_036016886.1  bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1 isoform X2

      Conserved Domains (2) summary
      pfam12062
      Location:30515
      HSNSD; heparan sulfate-N-deacetylase
      cl21551
      Location:605798
      Sulfotransfer_3; Sulfotransferase family
    4. XM_006525673.3XP_006525736.1  bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1 isoform X3

      Conserved Domains (2) summary
      pfam00685
      Location:181431
      Sulfotransfer_1; Sulfotransferase domain
      pfam12062
      Location:191
      HSNSD; heparan sulfate-N-deacetylase
    5. XM_036160994.1XP_036016887.1  bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1 isoform X3

      Conserved Domains (2) summary
      pfam00685
      Location:181431
      Sulfotransfer_1; Sulfotransferase domain
      pfam12062
      Location:191
      HSNSD; heparan sulfate-N-deacetylase
    6. XM_030250340.2XP_030106200.1  bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1 isoform X1

      UniProtKB/Swiss-Prot
      O70353, Q3TBX3, Q3TDS3, Q3UHN9, Q8BZE5, Q9R206
      Conserved Domains (2) summary
      pfam00685
      Location:605855
      Sulfotransfer_1; Sulfotransferase domain
      pfam12062
      Location:30515
      HSNSD; heparan sulfate-N-deacetylase
    7. XM_030250342.1XP_030106202.1  bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1 isoform X1

      UniProtKB/Swiss-Prot
      O70353, Q3TBX3, Q3TDS3, Q3UHN9, Q8BZE5, Q9R206
      Conserved Domains (2) summary
      pfam00685
      Location:605855
      Sulfotransfer_1; Sulfotransferase domain
      pfam12062
      Location:30515
      HSNSD; heparan sulfate-N-deacetylase
    8. XM_006525668.4XP_006525731.1  bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1 isoform X1

      See identical proteins and their annotated locations for XP_006525731.1

      UniProtKB/Swiss-Prot
      O70353, Q3TBX3, Q3TDS3, Q3UHN9, Q8BZE5, Q9R206
      Conserved Domains (2) summary
      pfam00685
      Location:605855
      Sulfotransfer_1; Sulfotransferase domain
      pfam12062
      Location:30515
      HSNSD; heparan sulfate-N-deacetylase
    9. XM_036160992.1XP_036016885.1  bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1 isoform X1

      UniProtKB/Swiss-Prot
      O70353, Q3TBX3, Q3TDS3, Q3UHN9, Q8BZE5, Q9R206
      Conserved Domains (2) summary
      pfam00685
      Location:605855
      Sulfotransfer_1; Sulfotransferase domain
      pfam12062
      Location:30515
      HSNSD; heparan sulfate-N-deacetylase