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    Sh3bp1 SH3-domain binding protein 1 [ Mus musculus (house mouse) ]

    Gene ID: 20401, updated on 27-Nov-2024

    Summary

    Official Symbol
    Sh3bp1provided by MGI
    Official Full Name
    SH3-domain binding protein 1provided by MGI
    Primary source
    MGI:MGI:104603
    See related
    Ensembl:ENSMUSG00000022436 AllianceGenome:MGI:104603
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    3BP-1
    Summary
    Enables GTPase activator activity and SH3 domain binding activity. Involved in positive regulation of GTPase activity and ruffle assembly. Located in bicellular tight junction. Orthologous to human SH3BP1 (SH3 domain binding protein 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in thymus adult (RPKM 61.6), spleen adult (RPKM 52.2) and 23 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Sh3bp1 in Genome Data Viewer
    Location:
    15 E1; 15 37.7 cM
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (78783994..78796247)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (78899768..78912052)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 26634 Neighboring gene STARR-positive B cell enhancer ABC_E11598 Neighboring gene STARR-positive B cell enhancer ABC_E7386 Neighboring gene golgi associated, gamma adaptin ear containing, ARF binding protein 1 Neighboring gene microRNA 6955 Neighboring gene STARR-seq mESC enhancer starr_39162 Neighboring gene STARR-positive B cell enhancer ABC_E480 Neighboring gene pyridoxal (pyridoxine, vitamin B6) phosphatase Neighboring gene predicted gene, 30368 Neighboring gene STARR-positive B cell enhancer ABC_E10867 Neighboring gene lectin, galactose binding, soluble 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables GTPase activator activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables GTPase activator activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables SH3 domain binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables semaphorin receptor binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables semaphorin receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in actin filament organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in actin filament organization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cell junction assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cell junction assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cell migration ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in establishment of epithelial cell apical/basal polarity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in establishment of epithelial cell apical/basal polarity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in filopodium assembly IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in filopodium assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of small GTPase mediated signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of small GTPase mediated signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of small GTPase mediated signal transduction ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in phagocytosis, engulfment ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in phagocytosis, engulfment ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of GTPase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of GTPase activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of Rac protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of actin cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of actin cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of actin filament depolymerization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of actin filament depolymerization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of blood vessel endothelial cell migration IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of blood vessel endothelial cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in ruffle assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in semaphorin-plexin signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in semaphorin-plexin signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in adherens junction ISO
    Inferred from Sequence Orthology
    more info
     
    located_in adherens junction ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in bicellular tight junction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in bicellular tight junction ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cell leading edge ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cell leading edge ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    part_of exocyst ISO
    Inferred from Sequence Orthology
    more info
     
    part_of exocyst ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in lamellipodium IEA
    Inferred from Electronic Annotation
    more info
     
    located_in lamellipodium ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in phagocytic cup ISO
    Inferred from Sequence Orthology
    more info
     
    located_in phagocytic cup ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    SH3 domain-binding protein 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001316684.2NP_001303613.1  SH3 domain-binding protein 1 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AL592169
      Consensus CDS
      CCDS84176.1
      UniProtKB/Swiss-Prot
      A2A5V4, E9QMQ2, P55194, Q99KK8
      UniProtKB/TrEMBL
      S4R2D3
      Related
      ENSMUSP00000001226.4, ENSMUST00000001226.11
      Conserved Domains (2) summary
      cd07620
      Location:16275
      BAR_SH3BP1; The Bin/Amphiphysin/Rvs (BAR) domain of SH3-domain Binding Protein 1
      cl02570
      Location:272473
      RhoGAP; RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when ...
    2. NM_001316685.2NP_001303614.1  SH3 domain-binding protein 1 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate splice site in its 3' coding region, compared to variant 1. The encoded isoform (3) has a shorter and distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AL592169
      Consensus CDS
      CCDS84177.1
      UniProtKB/TrEMBL
      A2A5V2, S4R2D3
      Related
      ENSMUSP00000105320.3, ENSMUST00000109698.9
      Conserved Domains (2) summary
      cl02570
      Location:272473
      RhoGAP; RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when ...
      cl12013
      Location:16275
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
    3. NM_009164.4NP_033190.2  SH3 domain-binding protein 1 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses two alternate splice sites in its 3' coding region, compared to variant 1. The encoded isoform (2) has a shorter and distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AL592169
      Consensus CDS
      CCDS27626.1
      UniProtKB/TrEMBL
      A2A5V3, S4R2D3
      Related
      ENSMUSP00000052181.8, ENSMUST00000061239.14
      Conserved Domains (2) summary
      cl02570
      Location:272473
      RhoGAP; RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when ...
      cl12013
      Location:16275
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    RNA

    1. NR_177652.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) uses an alternate splice site in a 5' exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AL592169
    2. NR_177653.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) has multiple differences compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AL592169
      Related
      ENSMUST00000151146.8

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      78783994..78796247
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001316686.1: Suppressed sequence

      Description
      NM_001316686.1: This RefSeq was removed because currently there is support for the transcript but not for the protein.
    2. NR_133564.1: Suppressed sequence

      Description
      NR_133564.1: This RefSeq was removed because currently there is insufficient support for the transcript.