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    Arhgef15 Rho guanine nucleotide exchange factor 15 [ Mus musculus (house mouse) ]

    Gene ID: 442801, updated on 9-Dec-2024

    Summary

    Official Symbol
    Arhgef15provided by MGI
    Official Full Name
    Rho guanine nucleotide exchange factor 15provided by MGI
    Primary source
    MGI:MGI:3045246
    See related
    Ensembl:ENSMUSG00000052921 AllianceGenome:MGI:3045246
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    E5; D130071N09; D530030K12Rik
    Summary
    Enables guanyl-nucleotide exchange factor activity. Involved in negative regulation of synapse maturation and regulation of postsynapse assembly. Acts upstream of or within retina vasculature morphogenesis in camera-type eye. Located in dendrite. Is active in glutamatergic synapse and postsynapse. Is expressed in several structures, including adipose tissue; alimentary system; genitourinary system; hemolymphoid system gland; and respiratory system. Orthologous to human ARHGEF15 (Rho guanine nucleotide exchange factor 15). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in lung adult (RPKM 39.8), adrenal adult (RPKM 12.1) and 15 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Arhgef15 in Genome Data Viewer
    Location:
    11 B3; 11 42.21 cM
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (68819726..68847760, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (68928900..68956934, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 22608 Neighboring gene outer dense fiber of sperm tails 4 Neighboring gene predicted gene, 51902 Neighboring gene STARR-positive B cell enhancer ABC_E8415 Neighboring gene predicted gene, 32273 Neighboring gene STARR-positive B cell enhancer ABC_E2994 Neighboring gene STARR-positive B cell enhancer ABC_E11482 Neighboring gene solute carrier family 25, member 35 Neighboring gene RAN guanine nucleotide release factor

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Clone Names

    • MGC102247, MGC144141, MGC144142

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GTPase activator activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables guanyl-nucleotide exchange factor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables guanyl-nucleotide exchange factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in dendrite IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in glutamatergic synapse IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    is_active_in postsynapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in postsynapse IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 

    General protein information

    Preferred Names
    rho guanine nucleotide exchange factor 15
    Names
    Rho guanine nucleotide exchange factor (GEF) 15
    ephexin-5

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001364772.2NP_001351701.1  rho guanine nucleotide exchange factor 15 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL603662
      Conserved Domains (2) summary
      smart00325
      Location:430606
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cd01221
      Location:630750
      PH_ephexin; Ephexin Pleckstrin homology (PH) domain
    2. NM_177566.5NP_808234.2  rho guanine nucleotide exchange factor 15 isoform 1

      See identical proteins and their annotated locations for NP_808234.2

      Status: VALIDATED

      Source sequence(s)
      AL603662
      Consensus CDS
      CCDS24873.1
      UniProtKB/Swiss-Prot
      Q14B44, Q5FWH6, Q69ZV7
      Related
      ENSMUSP00000067684.7, ENSMUST00000065040.13
      Conserved Domains (2) summary
      smart00325
      Location:430606
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cd01221
      Location:630750
      PH_ephexin; Ephexin Pleckstrin homology (PH) domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      68819726..68847760 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011249118.2XP_011247420.1  rho guanine nucleotide exchange factor 15 isoform X7

      Conserved Domains (2) summary
      smart00325
      Location:430606
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cd01221
      Location:630750
      PH_ephexin; Ephexin Pleckstrin homology (PH) domain
    2. XM_011249122.2XP_011247424.1  rho guanine nucleotide exchange factor 15 isoform X12

      Conserved Domains (2) summary
      smart00325
      Location:430606
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cd01221
      Location:630750
      PH_ephexin; Ephexin Pleckstrin homology (PH) domain
    3. XM_011249112.1XP_011247414.1  rho guanine nucleotide exchange factor 15 isoform X1

      Conserved Domains (2) summary
      smart00325
      Location:430606
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cd01221
      Location:630750
      PH_ephexin; Ephexin Pleckstrin homology (PH) domain
    4. XM_011249117.1XP_011247419.1  rho guanine nucleotide exchange factor 15 isoform X6

      Conserved Domains (2) summary
      smart00325
      Location:430606
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cd01221
      Location:630750
      PH_ephexin; Ephexin Pleckstrin homology (PH) domain
    5. XM_011249119.1XP_011247421.1  rho guanine nucleotide exchange factor 15 isoform X8

      Conserved Domains (2) summary
      smart00325
      Location:430606
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cd01221
      Location:630750
      PH_ephexin; Ephexin Pleckstrin homology (PH) domain
    6. XM_030246113.1XP_030101973.1  rho guanine nucleotide exchange factor 15 isoform X2

      Conserved Domains (2) summary
      smart00325
      Location:430606
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cd01221
      Location:630750
      PH_ephexin; Ephexin Pleckstrin homology (PH) domain
    7. XM_011249114.1XP_011247416.1  rho guanine nucleotide exchange factor 15 isoform X3

      Conserved Domains (2) summary
      smart00325
      Location:430606
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cd01221
      Location:630750
      PH_ephexin; Ephexin Pleckstrin homology (PH) domain
    8. XM_011249121.1XP_011247423.1  rho guanine nucleotide exchange factor 15 isoform X10

      Conserved Domains (2) summary
      smart00325
      Location:430606
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cd01221
      Location:630750
      PH_ephexin; Ephexin Pleckstrin homology (PH) domain
    9. XM_030246115.1XP_030101975.1  rho guanine nucleotide exchange factor 15 isoform X13

      Conserved Domains (2) summary
      smart00325
      Location:430606
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cl17171
      Location:630691
      PH-like; Pleckstrin homology-like domain
    10. XM_030246114.1XP_030101974.1  rho guanine nucleotide exchange factor 15 isoform X11

      Conserved Domains (2) summary
      smart00325
      Location:430606
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cl17171
      Location:630691
      PH-like; Pleckstrin homology-like domain
    11. XM_017314643.1XP_017170132.1  rho guanine nucleotide exchange factor 15 isoform X11

      Conserved Domains (2) summary
      smart00325
      Location:430606
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cl17171
      Location:630691
      PH-like; Pleckstrin homology-like domain
    12. XM_006533664.2XP_006533727.1  rho guanine nucleotide exchange factor 15 isoform X5

      See identical proteins and their annotated locations for XP_006533727.1

      UniProtKB/Swiss-Prot
      Q14B44, Q5FWH6, Q69ZV7
      Conserved Domains (2) summary
      smart00325
      Location:430606
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cd01221
      Location:630750
      PH_ephexin; Ephexin Pleckstrin homology (PH) domain
    13. XM_011249120.1XP_011247422.1  rho guanine nucleotide exchange factor 15 isoform X9

      Conserved Domains (2) summary
      smart00325
      Location:430606
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cd01221
      Location:630750
      PH_ephexin; Ephexin Pleckstrin homology (PH) domain
    14. XM_011249116.1XP_011247418.1  rho guanine nucleotide exchange factor 15 isoform X4

      See identical proteins and their annotated locations for XP_011247418.1

      Conserved Domains (2) summary
      smart00325
      Location:430606
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cd01221
      Location:630750
      PH_ephexin; Ephexin Pleckstrin homology (PH) domain
    15. XM_011249115.1XP_011247417.1  rho guanine nucleotide exchange factor 15 isoform X4

      See identical proteins and their annotated locations for XP_011247417.1

      Conserved Domains (2) summary
      smart00325
      Location:430606
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cd01221
      Location:630750
      PH_ephexin; Ephexin Pleckstrin homology (PH) domain
    16. XM_006533669.2XP_006533732.1  rho guanine nucleotide exchange factor 15 isoform X14

      See identical proteins and their annotated locations for XP_006533732.1

      Conserved Domains (2) summary
      smart00325
      Location:430606
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cl17171
      Location:630691
      PH-like; Pleckstrin homology-like domain

    RNA

    1. XR_879714.4 RNA Sequence

    2. XR_001780023.1 RNA Sequence

    3. XR_388488.2 RNA Sequence

    4. XR_003949471.1 RNA Sequence

    5. XR_388487.3 RNA Sequence