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    Nqo2 N-ribosyldihydronicotinamide quinone reductase 2 [ Mus musculus (house mouse) ]

    Gene ID: 18105, updated on 3-Dec-2024

    Summary

    Official Symbol
    Nqo2provided by MGI
    Official Full Name
    N-ribosyldihydronicotinamide quinone reductase 2provided by MGI
    Primary source
    MGI:MGI:104513
    See related
    Ensembl:ENSMUSG00000046949 AllianceGenome:MGI:104513
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ox2; NMO2; Nmor2
    Summary
    Predicted to enable several functions, including anion binding activity; dihydronicotinamide riboside quinone reductase activity; and melatonin binding activity. Predicted to be involved in several processes, including positive regulation of ERK1 and ERK2 cascade; positive regulation of vascular associated smooth muscle cell proliferation; and quinone catabolic process. Predicted to be located in nucleoplasm. Predicted to be active in cytosol. Is expressed in adenohypophysis. Human ortholog(s) of this gene implicated in Parkinson's disease; agranulocytosis; breast cancer; and breast carcinoma. Orthologous to human NQO2 (N-ribosyldihydronicotinamide:quinone dehydrogenase 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in liver adult (RPKM 9.5), placenta adult (RPKM 5.0) and 27 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Nqo2 in Genome Data Viewer
    Location:
    13 A3.3; 13 14.01 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (34148642..34172448)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (33964655..33988465)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene serine (or cysteine) peptidase inhibitor, clade B, member 6c Neighboring gene STARR-seq mESC enhancer starr_34132 Neighboring gene serine (or cysteine) peptidase inhibitor, clade B, member 6a Neighboring gene RIKEN cDNA 1110046J04 gene Neighboring gene STARR-positive B cell enhancer ABC_E2403 Neighboring gene receptor (TNFRSF)-interacting serine-threonine kinase 1 Neighboring gene biphenyl hydrolase like

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (2)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables FAD binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables FAD binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables NAD(P)H dehydrogenase (quinone) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables chloride ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables chloride ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables dihydronicotinamide riboside quinone reductase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables dihydronicotinamide riboside quinone reductase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables electron transfer activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables electron transfer activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables melatonin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables melatonin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables oxidoreductase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables oxidoreductase activity, acting on other nitrogenous compounds as donors IEA
    Inferred from Electronic Annotation
    more info
     
    enables oxidoreductase activity, acting on other nitrogenous compounds as donors ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein homodimerization activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables resveratrol binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables resveratrol binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables zinc ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    ribosyldihydronicotinamide dehydrogenase [quinone]
    Names
    NAD(P)H dehydrogenase, quinone 2
    NAD(P)H menadione oxidoreductase 2, dioxin inducible
    NRH dehydrogenase [quinone] 2
    NRH: quinone oxidoreductase
    NRH:quinone oxidoreductase 2
    QR2
    quinone reductase 2
    ribosyldihydronicotinamide dehydrogenase
    NP_001156711.1
    NP_001156713.1
    NP_001156714.1
    NP_001413070.1
    NP_001413071.1
    NP_001413086.1
    NP_001413090.1
    NP_001413091.1
    NP_001413092.1
    NP_001413093.1
    NP_001413095.1
    NP_001413096.1
    NP_001413102.1
    NP_001413103.1
    NP_001413104.1
    NP_001413105.1
    NP_001413107.1
    NP_001413109.1
    NP_064678.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001163239.1NP_001156711.1  ribosyldihydronicotinamide dehydrogenase [quinone] isoform 2

      See identical proteins and their annotated locations for NP_001156711.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is shorter than isoform 1.
      Source sequence(s)
      AC161461, AK008465
      Consensus CDS
      CCDS88437.1
      UniProtKB/TrEMBL
      A0A1Y7VL95
      Related
      ENSMUSP00000152068.2, ENSMUST00000220844.2
      Conserved Domains (1) summary
      pfam02525
      Location:18168
      Flavodoxin_2; Flavodoxin-like fold
    2. NM_001163241.2NP_001156713.1  ribosyldihydronicotinamide dehydrogenase [quinone] isoform 1

      See identical proteins and their annotated locations for NP_001156713.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same isoform (1).
      Source sequence(s)
      AC161461
      Consensus CDS
      CCDS26442.1
      UniProtKB/Swiss-Prot
      Q9JI75
      UniProtKB/TrEMBL
      Q9CVI1
      Related
      ENSMUSP00000053809.8, ENSMUST00000058978.9
      Conserved Domains (1) summary
      COG2249
      Location:4215
      MdaB; Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]
    3. NM_001163242.2NP_001156714.1  ribosyldihydronicotinamide dehydrogenase [quinone] isoform 1

      See identical proteins and their annotated locations for NP_001156714.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same isoform (1).
      Source sequence(s)
      AC161461
      Consensus CDS
      CCDS26442.1
      UniProtKB/Swiss-Prot
      Q9JI75
      UniProtKB/TrEMBL
      Q9CVI1
      Related
      ENSMUSP00000152294.2, ENSMUST00000222740.2
      Conserved Domains (1) summary
      COG2249
      Location:4215
      MdaB; Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]
    4. NM_001426141.1NP_001413070.1  ribosyldihydronicotinamide dehydrogenase [quinone] isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC161461
      UniProtKB/Swiss-Prot
      Q9JI75
      UniProtKB/TrEMBL
      Q9CVI1
      Related
      ENSMUSP00000152598.2, ENSMUST00000223479.2
    5. NM_001426142.1NP_001413071.1  ribosyldihydronicotinamide dehydrogenase [quinone] isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC161461
      UniProtKB/Swiss-Prot
      Q9JI75
      UniProtKB/TrEMBL
      Q9CVI1
    6. NM_001426157.1NP_001413086.1  ribosyldihydronicotinamide dehydrogenase [quinone] isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC161461
      UniProtKB/TrEMBL
      Q9CVI1
    7. NM_001426161.1NP_001413090.1  ribosyldihydronicotinamide dehydrogenase [quinone] isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC161461
      UniProtKB/TrEMBL
      Q9CVI1
    8. NM_001426162.1NP_001413091.1  ribosyldihydronicotinamide dehydrogenase [quinone] isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC161461
      UniProtKB/TrEMBL
      Q9CVI1
    9. NM_001426163.1NP_001413092.1  ribosyldihydronicotinamide dehydrogenase [quinone] isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC161461
    10. NM_001426164.1NP_001413093.1  ribosyldihydronicotinamide dehydrogenase [quinone] isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC161461
    11. NM_001426166.1NP_001413095.1  ribosyldihydronicotinamide dehydrogenase [quinone] isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC161461
    12. NM_001426167.1NP_001413096.1  ribosyldihydronicotinamide dehydrogenase [quinone] isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC161461
    13. NM_001426173.1NP_001413102.1  ribosyldihydronicotinamide dehydrogenase [quinone] isoform 7

      Status: VALIDATED

      Source sequence(s)
      AC161461
      UniProtKB/TrEMBL
      A0A1Y7VL95
    14. NM_001426174.1NP_001413103.1  ribosyldihydronicotinamide dehydrogenase [quinone] isoform 7

      Status: VALIDATED

      Source sequence(s)
      AC161461
      UniProtKB/TrEMBL
      A0A1Y7VL95
    15. NM_001426175.1NP_001413104.1  ribosyldihydronicotinamide dehydrogenase [quinone] isoform 8

      Status: VALIDATED

      Source sequence(s)
      AC161461
    16. NM_001426176.1NP_001413105.1  ribosyldihydronicotinamide dehydrogenase [quinone] isoform 8

      Status: VALIDATED

      Source sequence(s)
      AC161461
    17. NM_001426178.1NP_001413107.1  ribosyldihydronicotinamide dehydrogenase [quinone] isoform 8

      Status: VALIDATED

      Source sequence(s)
      AC161461
    18. NM_001426180.1NP_001413109.1  ribosyldihydronicotinamide dehydrogenase [quinone] isoform 9

      Status: VALIDATED

      Source sequence(s)
      AC161461
    19. NM_020282.4NP_064678.1  ribosyldihydronicotinamide dehydrogenase [quinone] isoform 1

      See identical proteins and their annotated locations for NP_064678.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1). Variants 1, 2 and 3 encode the same isoform (1).
      Source sequence(s)
      AC161461
      Consensus CDS
      CCDS26442.1
      UniProtKB/Swiss-Prot
      Q9JI75
      UniProtKB/TrEMBL
      Q9CVI1
      Related
      ENSMUSP00000021843.6, ENSMUST00000021843.13
      Conserved Domains (1) summary
      COG2249
      Location:4215
      MdaB; Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      34148642..34172448
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)