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    Mettl13 methyltransferase 13, eEF1A lysine and N-terminal methyltransferase [ Mus musculus (house mouse) ]

    Gene ID: 71449, updated on 9-Dec-2024

    Summary

    Official Symbol
    Mettl13provided by MGI
    Official Full Name
    methyltransferase 13, eEF1A lysine and N-terminal methyltransferaseprovided by MGI
    Primary source
    MGI:MGI:1918699
    See related
    Ensembl:ENSMUSG00000026694 AllianceGenome:MGI:1918699
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Eef1aknmt; 5630401D24Rik
    Summary
    Predicted to enable protein-lysine N-methyltransferase activity. Predicted to be involved in negative regulation of cell cycle G1/S phase transition and negative regulation of transcription by RNA polymerase II. Located in mitochondrion and nucleus. Is expressed in axial musculature; cochlear ganglion; inner ear; and submandibular gland primordium. Orthologous to human METTL13 (methyltransferase 13, eEF1A N-terminus and K55). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 6.1), limb E14.5 (RPKM 5.7) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Mettl13 in Genome Data Viewer
    Location:
    1 H2.1; 1 70.29 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (162359694..162376098, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (162533671..162548541, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene dynamin 3 Neighboring gene predicted gene, 31985 Neighboring gene predicted gene, 46247 Neighboring gene STARR-positive B cell enhancer ABC_E5839 Neighboring gene STARR-positive B cell enhancer ABC_E7767 Neighboring gene STARR-positive B cell enhancer ABC_E10051 Neighboring gene vesicle-associated membrane protein 4 Neighboring gene eukaryotic translation initiation factor 4E family member 1B pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (6) 
    • Targeted (1)  1 citation

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
     
    enables protein-lysine N-methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein-lysine N-methyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in methylation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of cell cycle G1/S phase transition ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    eEF1A lysine and N-terminal methyltransferase
    Names
    EEF1A lysine and N-terminal methyltransferase
    eEF1A-KNMT
    methyltransferase like 13
    methyltransferase-like protein 13
    NP_001404810.1
    NP_001404811.1
    NP_659126.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001417881.1NP_001404810.1  eEF1A lysine and N-terminal methyltransferase isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC138218
    2. NM_001417882.1NP_001404811.1  eEF1A lysine and N-terminal methyltransferase isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC138218
    3. NM_144877.2NP_659126.1  eEF1A lysine and N-terminal methyltransferase isoform 1

      See identical proteins and their annotated locations for NP_659126.1

      Status: VALIDATED

      Source sequence(s)
      AC138218
      Consensus CDS
      CCDS15420.1
      UniProtKB/Swiss-Prot
      Q3TF24, Q3TFY3, Q69ZX4, Q8BWN2, Q8BX81, Q91YR5
      Related
      ENSMUSP00000028017.9, ENSMUST00000028017.16
      Conserved Domains (3) summary
      COG0500
      Location:501649
      SmtA; SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only]
      pfam08241
      Location:53158
      Methyltransf_11; Methyltransferase domain
      cl17173
      Location:500672
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

    RNA

    1. NR_184652.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC138218

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      162359694..162376098 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)